WormBase Tree Display for Gene: WBGene00010706

WBGene00010706 SMap: S_parent: Sequence: K09A11
  Identity: Version: 3
    Name: CGC_name: cyp-14A2
      Sequence_name: K09A11.3
      Molecular_name: K09A11.3
        K09A11.3.1
        CE03474
      Other_name: tag-190 Person_evidence: WBPerson201
        CELE_K09A11.3 Accession_evidence: NDB BX284606
      Public_name: cyp-14A2
    DB_info: Database: AceView gene XN886
        WormQTL gene WBGene00010706
        WormFlux gene WBGene00010706
        NDB locus_tag CELE_K09A11.3
        Panther gene CAEEL|WormBase=WBGene00010706|UniProtKB=Q27505
          family PTHR24284
        NCBI gene 187184
        RefSeq protein NM_077803.4
        TrEMBL UniProtAcc Q27505
        UniProt_GCRP UniProtAcc Q27505
        OMIM gene 610670
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:51 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 21 Sep 2004 09:38:16 WBPerson1971 Name_change: CGC_name: cyp-14A2
        3 06 Oct 2005 10:42:54 WBPerson2970 Event: Acquires_merge: WBGene00007051
              Name_change: Other_name: tag-190
      Acquires_merge: WBGene00007051
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyp
    Allele (27)
    Strain: WBStrain00035912
    RNASeq_FPKM (74)
    GO_annotation: 00079908
      00079909
      00079910
      00118051
      00118052
      00118053
      00118054
    Ortholog (76)
    Paralog (42)
    Structured_description: Concise_description: cyp-14A2 encodes one of ~80 C. elegans cytochrome P450s: membrane-associated, heme-containing NADPH-dependent monooxygenases that catalyze the oxidative metabolism of a variety of exogenous compounds and endogenous substrates. Curator_confirmed: WBPerson1843
          Date_last_updated: 20 Nov 2008 00:00:00
      Automated_description: Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity. Expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; hematologic cancer (multiple); and hereditary spastic paraplegia 56. Is an ortholog of several human genes including CYP2D6 (cytochrome P450 family 2 subfamily D member 6); CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)); and CYP2W1 (cytochrome P450 family 2 subfamily W member 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (12)
  Molecular_info: Corresponding_CDS: K09A11.3
    Corresponding_transcript: K09A11.3.1
    Other_sequence: ACC10519_1
      Acan_isotig16510
      Acan_isotig20860
      PPC14875_1
      ACC19344_1
      ACC37757_1
      FC540658.1
      FC546538.1
      FC544295.1
      Oden_isotig28571
    Associated_feature: WBsf238118
  Experimental_info: RNAi_result: WBRNAi00050361 Inferred_automatically: RNAi_primary
      WBRNAi00081517 Inferred_automatically: RNAi_primary
      WBRNAi00081539 Inferred_automatically: RNAi_primary
      WBRNAi00016860 Inferred_automatically: RNAi_primary
      WBRNAi00034175 Inferred_automatically: RNAi_primary
      WBRNAi00081492 Inferred_automatically: RNAi_primary
      WBRNAi00092633 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr8188
      Expr1015820
      Expr1154066
      Expr2010692
      Expr2028931
    Drives_construct: WBCnstr00004994
      WBCnstr00031203
    Construct_product: WBCnstr00031203
    Microarray_results (15)
    Expression_cluster (207)
    Interaction: WBInteraction000032180
      WBInteraction000145443
      WBInteraction000155641
      WBInteraction000156225
      WBInteraction000171003
      WBInteraction000580718
  Map_info: Map: X Position: 11.1054 Error: 0.0367
    Positive: Positive_clone: K09A11 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5542
        4661
        5082
    Pseudo_map_position
  Reference: WBPaper00031529
    WBPaper00038491
    WBPaper00055090
    WBPaper00062515
    WBPaper00065988
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene