WormBase Tree Display for Gene: WBGene00010593

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WBGene00010593	SMap	S_parent	Sequence	K06A4
	Identity	Version	2
		Name	CGC_name	gsnl-1	Person_evidence	WBPerson463
			Sequence_name	K06A4.3
			Molecular_name	K06A4.3
				K06A4.3.1
				CE06107
			Other_name	CELE_K06A4.3	Accession_evidence	NDB	BX284605
			Public_name	gsnl-1
		DB_info	Database	AceView	gene	5J979
				WormQTL	gene	WBGene00010593
				WormFlux	gene	WBGene00010593
				NDB	locus_tag	CELE_K06A4.3
				Panther	gene	CAEEL\|WormBase=WBGene00010593\|UniProtKB=Q21253
					family	PTHR11977
				NCBI	gene	179328
				RefSeq	protein	NM_073047.8
				SwissProt	UniProtAcc	Q21253
				UniProt_GCRP	UniProtAcc	Q21253
				OMIM	gene	137350
						613397
		Species	Caenorhabditis elegans
		History	Version_change	1	26 May 2004 16:54:51	WBPerson1971	Event	Imported	Initial conversion from CDS class of WS125
				2	20 Feb 2008 14:38:15	WBPerson2970	Name_change	CGC_name	gsnl-1
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	gsnl
		Allele (43)
		Strain	WBStrain00003672
			WBStrain00032880
		RNASeq_FPKM (74)
		GO_annotation (29)
		Ortholog (63)
		Paralog	WBGene00001443	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00015691	Caenorhabditis elegans	From_analysis	Panther
						WormBase-Compara
		Structured_description	Concise_description	gsnl-1 encodes one of three C. elegans gelsolin-related proteins; GSNL-1 contains four gelsolin-like (G) domains; GSNL-1 is predicted to function in vivo as an actin regulatory protein and in vitro, demonstrates actin filament severing activity; GSNL-1 also exhibits calcium-dependent capping of the barbed ends of actin filaments and stays bound to the side of actin filaments; GSNL-1 additionally binds to G-actin.	Paper_evidence	WBPaper00032034
					Curator_confirmed	WBPerson1843
					Date_last_updated	29 Jan 2010 00:00:00
			Automated_description	Enables actin filament binding activity; actin monomer binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in actin filament-based process and regulation of cellular component organization. Located in actin cytoskeleton and striated muscle dense body. Expressed in hypodermis. Human ortholog(s) of this gene implicated in several diseases, including Finnish type amyloidosis; artery disease (multiple); and gas gangrene. Is an ortholog of human CAPG (capping actin protein, gelsolin like).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Disease_info	Potential_model	DOID:0050637	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:4620)
			DOID:8481	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:4620)
			DOID:5844	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:4620)
			DOID:3526	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:4620)
			DOID:0112267	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:14188)
			DOID:10591	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:4620)
			DOID:9159	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:4620)
	Molecular_info	Corresponding_CDS	K06A4.3
		Corresponding_transcript	K06A4.3.1
		Other_sequence (142)
		Associated_feature	WBsf647077
			WBsf647078
			WBsf1000922
			WBsf1020191
			WBsf232255
	Experimental_info	RNAi_result	WBRNAi00016655	Inferred_automatically	RNAi_primary
			WBRNAi00060080	Inferred_automatically	RNAi_primary
			WBRNAi00060078	Inferred_automatically	RNAi_primary
			WBRNAi00114651	Inferred_automatically	RNAi_primary
			WBRNAi00060079	Inferred_automatically	RNAi_primary
			WBRNAi00060081	Inferred_automatically	RNAi_primary
			WBRNAi00034003	Inferred_automatically	RNAi_primary
			WBRNAi00050022	Inferred_automatically	RNAi_primary
			WBRNAi00092978	Inferred_automatically	RNAi_primary
			WBRNAi00103437	Inferred_automatically	RNAi_primary
		Expr_pattern (11)
		Drives_construct	WBCnstr00004074
			WBCnstr00004108
			WBCnstr00011457
			WBCnstr00031298
		Construct_product	WBCnstr00011477
			WBCnstr00014146
			WBCnstr00020660
			WBCnstr00031298
		Microarray_results (19)
		Expression_cluster	WBPaper00029047:atx-3_upregulated
			WBPaper00031040:Cluster_5
			WBPaper00031040:TGF-beta_adult_upregulated
			WBPaper00032528:L3_enriched
			WBPaper00037946:EGL-5_interacting
			WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
			WBPaper00037950:bodywall-muscle_L1-larva_expressed
			WBPaper00037950:bodywall-muscle_L2-larva_expressed
			WBPaper00037950:bodywall-muscle_larva_enriched
			WBPaper00037950:bodywall-muscle_larva_SelectivelyEnriched
			WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
			WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
			WBPaper00044128:daf-2(e1370)_upregulated
			WBPaper00044246:pgrn-1_ced-1_downregulated
			WBPaper00044316:CH3HgCl_2.0uM_downregulated
			WBPaper00044316:CH3HgCl_7.5uM_downregulated
			WBPaper00044501:gld-1_let-7_regulated
			WBPaper00044578:reduced-humidity_downregulated_microarray
			WBPaper00044736:flat_dev_expression
			WBPaper00045417:128Q-huntingtin_upreglated
			WBPaper00045521:Gender_Neutral
			WBPaper00045571:germline-ablation_upregulated
			WBPaper00045934:wrn-1(gk99)_downregulated
			WBPaper00046012:tdp-1(ok803)_upregulated
			WBPaper00046121:mesoderm_unique
			WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
			WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
			WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
			WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
			WBPaper00046509:htz-1(ok3099)_upregulated
			WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
			WBPaper00047131:daf-2(e1370)_upregulated_N2-background
			WBPaper00048988:neuron_expressed
			WBPaper00049217:TCER-1_downregulated
			WBPaper00050080:rbr-2(tm3141)_upregulated
			WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
			WBPaper00050332:daf-16(RNAi)_downregulated
			WBPaper00050370:dpy-21(e428)_L3_downregulated
			WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C
			WBPaper00050698:DEP-1_interacting
			WBPaper00050726:OsmoticStress_regulated_Food
			WBPaper00050726:OsmoticStress_regulated_NoFood
			WBPaper00050801:DAF-12_dauer_regulome
			WBPaper00050801:DAF-16_dauer_regulome
			WBPaper00050801:DPY-21_dauer_regulome
			WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
			WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
			WBPaper00050990:GABAergic-neuron_expressed
			WBPaper00050990:seam_expressed
			WBPaper00051245:body-wall-muscle_cytoplasm_expressed
			WBPaper00051245:body-wall-muscle_nucleus_expressed
			WBPaper00051245:cytoplasm_specific
			WBPaper00051245:epidermis_cytoplasm_expressed
			WBPaper00051245:intestine_cytoplasm_expressed
			WBPaper00052884:emb-4(hc60)_upregulated
			WBPaper00053184:sma-2(rax5)_upregulated
			WBPaper00053184:sma-4(rax3)_upregulated
			WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
			WBPaper00053321:PGCs_depleted_NuGen
			WBPaper00053388:dauer_regulated_Cluster3
			WBPaper00053615:SMO-1_target
			WBPaper00053657:N2_M.humicola-infection_24hr
			WBPaper00053810:daf-2(e1370)_upregulated
			WBPaper00053814:15C_downregulated_PY79
			WBPaper00055103:thoc-5(wy822)_downregulated
			WBPaper00055354:Rapamycin-Allantoin_downregulated
			WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
			WBPaper00055354:Rapamycin-Rifampicin_upregulated
			WBPaper00055354:Rifampicin-Psora_upregulated
			WBPaper00055354:Rifampicin_upregulated
			WBPaper00055862:antimycin_damt-1(gk961032)_regulated
			WBPaper00055971:nhl-2(ok818)_25C_upregulated
			WBPaper00056034:pals-22(jy3)_upregulated
			WBPaper00056034:pals-25(jy9)_upregulated
			WBPaper00056090:E.faecalis_downregulated_N2
			WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
			WBPaper00056218:daf-16(mu86)_upregulated_Day3
			WBPaper00056443:DietaryRestriction_downregulated
			WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
			WBPaper00056471:S.aureus-4h_downregulated_N2
			WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
			WBPaper00057041:spc-1(cas971)_downregulated
			WBPaper00057154:HeatShock_upregulated_mRNA
			WBPaper00058598:mex-3(eu149)_upregulated
			WBPaper00058598:sin-3(tm1276)_downregulated
			WBPaper00058691:set-2(bn129)_upregulated
			WBPaper00058711:wdr-5(ok1417)_upregulated
			WBPaper00059117:B.subtilis_downregulated
			WBPaper00059328:mrps-5(RNAi)_downregulated_protein
			WBPaper00059664:srbc-48(ac23)_upregulated
			WBPaper00059824:rnp-6(dh1127)_regulated_OP50
			WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
			WBPaper00059987:Wounding_upregulated
			WBPaper00060014:set-2(tm1630)_downregulated
			WBPaper00060100:SiNP_downregulated_mRNA
			WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
			WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
			WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
			WBPaper00060526:plp-1(ok2155)_upregulated
			WBPaper00060661:sensory-neuron_depleted
			WBPaper00060911:prx-5(RNAi)_downregulated_mRNA
			WBPaper00061007:HB101_upregulated
			WBPaper00061040:eat-2(ad1116)_upregulated
			WBPaper00061203:sin-3(tm1276)_upregulated
			WBPaper00061203:spr-1(ok2144)_upregulated
			WBPaper00061340:BWM_anterior
			WBPaper00061340:BWM_far_posterior
			WBPaper00061405:S.aureus_downregulated_starvation
			WBPaper00061479:hda-1(ne4752)_upregulated
			WBPaper00061527:mup-2-unc-87_284
			WBPaper00061818:ELKS-1_interacting
			WBPaper00062056:lin-37(n758)_downregulated
			WBPaper00062159:hda-2(ok1479)_upregulated
			WBPaper00062325:etr-1(lq61)_upregulated
			WBPaper00062325:muscle_enriched_coding-RNA
			WBPaper00062590:Aging_downregulated_neuron
			WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
			WBPaper00064005:starvation_downregulated_N2_mRNA
			WBPaper00064005:starvation_upregulated_aptf-1(gk794)_protein
			WBPaper00064071:NHR-49_interacting
			WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
			WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
			WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
			WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
			WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
			WBPaper00064716:paraquat_downregulated
			WBPaper00064727:daf-2(e1370)_upregulated
			WBPaper00064789:Day9_vs_Day1_upregulated_neuron
			WBPaper00065096:25C_vs_20C_downregulated
			WBPaper00065096:Day10_vs_Day1_downregulated
			WBPaper00065258:anchor-cell_depleted
			WBPaper00065373:Cisplatin_upregulated_WT
			WBPaper00065373:sek-1(km4)_downregulated_cisplatin
			WBPaper00065835:Day5_vs_Day1_downregulated
			WBPaper00065835:Day11_vs_Day1_downregulated
			WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11
			WBPaper00065841:1_1
			WBPaper00065841:4_0
			WBPaper00065841:4_1
			WBPaper00065841:7_2
			WBPaper00065841:38_0
			WBPaper00065841:38_3
			WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein
			WBPaper00065975:P-body_vs_WholeAnimal_depleted
			WBPaper00065993:glp-1(e2141)_upregulated
			WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
			cgc4386_cluster_2_5
			cgc4489_group_24
			WBPaper00025141:N2_Expressed_Genes
			WBPaper00026929:sir-2.1_overexpression_regulated
			WBPaper00029437:dcr-1_upregulated
			WBPaper00031003:0hr_muscle_enriched
			WBPaper00031003:24hr_muscle_enriched
			WBPaper00031003:hlh_1_enriched
			WBPaper00031003:total_muscle_enriched
			WBPaper00031532:Larva_Pan_Neuronal_Depleted
			WBPaper00032165:differentially_expressed_with_age_medoid_6
			WBPaper00035588:alg-1(-)_upregulated
			WBPaper00035873:dpy-9_regulated
			WBPaper00035873:dpy-10_regulated
			WBPaper00036123:Atrazine_regulated
			WBPaper00036286:Pattern_C
			WBPaper00036383:ash-2_Day8_regulated
			WBPaper00038304:octr-1_regulated
			WBPaper00039866:ClassComp_daf-19_upregulated
			WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
			WBPaper00040210:Diazinon_24C_regulated
			WBPaper00040426:CYD-1_CDK-4_downregulated
			WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
			WBPaper00040963:Q50_up
			WBPaper00041606:CE_X.nematophila_regulated
			WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
			WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
			WBPaper00042258:DA1877_upregulated_GravidAdult
			WBPaper00042331:a-SWCNTs_downregulated
			WBPaper00044091:Bpseudomallei_repressed_12h
			WBPaper00048989:N2_rapamycin_upregulated
			WBPaper00053236:daf-16(mgDF50)_regulated_Starved
			WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo
			WBPaper00055899:nitroguanidine_regulated
			[cgc6390]:Cluster_A
		Interaction (73)
	Map_info	Map	V	Position	2.03074	Error	0.001424
		Positive	Positive_clone	K06A4	Inferred_automatically	From sequence, transcript, pseudogene data
		Pseudo_map_position
	Reference (13)
	Remark	Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene