WormBase Tree Display for Gene: WBGene00010593

WBGene00010593 SMap: S_parent: Sequence: K06A4
  Identity: Version: 2
    Name: CGC_name: gsnl-1 Person_evidence: WBPerson463
      Sequence_name: K06A4.3
      Molecular_name: K06A4.3
        K06A4.3.1
        CE06107
      Other_name: CELE_K06A4.3 Accession_evidence: NDB BX284605
      Public_name: gsnl-1
    DB_info: Database: AceView gene 5J979
        WormQTL gene WBGene00010593
        WormFlux gene WBGene00010593
        NDB locus_tag CELE_K06A4.3
        Panther gene CAEEL|WormBase=WBGene00010593|UniProtKB=Q21253
          family PTHR11977
        NCBI gene 179328
        RefSeq protein NM_073047.8
        SwissProt UniProtAcc Q21253
        UniProt_GCRP UniProtAcc Q21253
        OMIM gene 137350
            613397
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:51 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 20 Feb 2008 14:38:15 WBPerson2970 Name_change: CGC_name: gsnl-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: gsnl
    Allele (43)
    Strain: WBStrain00003672
      WBStrain00032880
    RNASeq_FPKM (74)
    GO_annotation (29)
    Ortholog (63)
    Paralog: WBGene00001443 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00015691 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: gsnl-1 encodes one of three C. elegans gelsolin-related proteins; GSNL-1 contains four gelsolin-like (G) domains; GSNL-1 is predicted to function in vivo as an actin regulatory protein and in vitro, demonstrates actin filament severing activity; GSNL-1 also exhibits calcium-dependent capping of the barbed ends of actin filaments and stays bound to the side of actin filaments; GSNL-1 additionally binds to G-actin. Paper_evidence: WBPaper00032034
          Curator_confirmed: WBPerson1843
          Date_last_updated: 29 Jan 2010 00:00:00
      Automated_description: Enables actin filament binding activity; actin monomer binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in actin filament-based process and regulation of cellular component organization. Located in actin cytoskeleton and striated muscle dense body. Expressed in hypodermis. Human ortholog(s) of this gene implicated in several diseases, including Finnish type amyloidosis; artery disease (multiple); and gas gangrene. Is an ortholog of human CAPG (capping actin protein, gelsolin like). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0050637 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4620)
      DOID:8481 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4620)
      DOID:5844 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4620)
      DOID:3526 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4620)
      DOID:0112267 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14188)
      DOID:10591 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4620)
      DOID:9159 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4620)
  Molecular_info: Corresponding_CDS: K06A4.3
    Corresponding_transcript: K06A4.3.1
    Other_sequence (142)
    Associated_feature: WBsf647077
      WBsf647078
      WBsf1000922
      WBsf1020191
      WBsf232255
  Experimental_info: RNAi_result: WBRNAi00016655 Inferred_automatically: RNAi_primary
      WBRNAi00060080 Inferred_automatically: RNAi_primary
      WBRNAi00060078 Inferred_automatically: RNAi_primary
      WBRNAi00114651 Inferred_automatically: RNAi_primary
      WBRNAi00060079 Inferred_automatically: RNAi_primary
      WBRNAi00060081 Inferred_automatically: RNAi_primary
      WBRNAi00034003 Inferred_automatically: RNAi_primary
      WBRNAi00050022 Inferred_automatically: RNAi_primary
      WBRNAi00092978 Inferred_automatically: RNAi_primary
      WBRNAi00103437 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00004074
      WBCnstr00004108
      WBCnstr00011457
      WBCnstr00031298
    Construct_product: WBCnstr00011477
      WBCnstr00014146
      WBCnstr00020660
      WBCnstr00031298
    Microarray_results (19)
    Expression_cluster (181)
    Interaction (73)
  Map_info: Map: V Position: 2.03074 Error: 0.001424
    Positive: Positive_clone: K06A4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (13)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene