WormBase Tree Display for Gene: WBGene00010589

WBGene00010589 SMap: S_parent: Sequence: K05D4
  Identity: Version: 2
    Name: CGC_name: cyp-33D1
      Sequence_name: K05D4.4
      Molecular_name: K05D4.4
        K05D4.4.1
        CE16230
      Other_name: CELE_K05D4.4 Accession_evidence: NDB BX284605
      Public_name: cyp-33D1
    DB_info: Database: AceView gene 5Q654
        WormQTL gene WBGene00010589
        WormFlux gene WBGene00010589
        NDB locus_tag CELE_K05D4.4
        Panther gene CAEEL|WormBase=WBGene00010589|UniProtKB=O45659
          family PTHR24300
        NCBI gene 187025
        RefSeq protein NM_074675.4
        TrEMBL UniProtAcc O45659
        UniProt_GCRP UniProtAcc O45659
        OMIM gene 601130
            608713
            610670
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:51 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 21 Sep 2004 09:38:16 WBPerson1971 Name_change: CGC_name: cyp-33D1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyp
    Allele (106)
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog (110)
    Paralog (44)
    Structured_description: Automated_description: Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Predicted to be involved in organic acid metabolic process and xenobiotic metabolic process. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including Keshan disease; glucose metabolism disease (multiple); and hematologic cancer (multiple). Is an ortholog of several human genes including CYP2B6 (cytochrome P450 family 2 subfamily B member 6); CYP2C19 (cytochrome P450 family 2 subfamily C member 19); and CYP2C8 (cytochrome P450 family 2 subfamily C member 8). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (46)
  Molecular_info: Corresponding_CDS: K05D4.4
    Corresponding_transcript: K05D4.4.1
    Other_sequence: RSC03604_1
      MIC02995_1
      MI08796
      BE240839.1
      BUC01913_1
      MIC09202_1
      Tcol_isotig20062
      Oden_isotig19900
      MI03478
    Associated_feature: WBsf235123
  Experimental_info: RNAi_result: WBRNAi00049983 Inferred_automatically: RNAi_primary
      WBRNAi00033985 Inferred_automatically: RNAi_primary
      WBRNAi00092666 Inferred_automatically: RNAi_primary
      WBRNAi00016623 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1020206
      Expr1153678
      Expr2010721
      Expr2028959
    Drives_construct: WBCnstr00031301
    Construct_product: WBCnstr00031301
    Microarray_results (18)
    Expression_cluster: WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045774:clk-1_upregulated
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048923:Aging_regulated
      WBPaper00049368:daf-2(e1370)_upregulated
      WBPaper00049377:MWCNT_upregulated
      WBPaper00049489:AMsh-glia_enriched
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00050370:dpy-21(e428)_L3_downregulated
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00053308:SMG-2_associated_NMD(-)_upregulated_ClassI
      WBPaper00053402:cco-1(RNAi)_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00053771:up_at_24h-NaCl
      WBPaper00053810:clk-1(qm30)_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:isp-1(qm150)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055827:daf-2(e1370)_upregulated
      WBPaper00055827:pfd-6(gk493446)_upregulated
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060445:ikb-1(nr2027)_upregulated_L1
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061527:sre-33-ZK1025.1_8337
      WBPaper00061699:daf-18(ok480)_downregulated
      WBPaper00061952:daf-18(nr2037)_downregulated
      WBPaper00061952:daf-18(yh1)_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066110:Cisplatin_upregulated_tetraploid
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4489_group_15
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00036123:Atrazine_regulated
      WBPaper00036286:Pattern_I
      WBPaper00036375:depleted_in_PVD_OLL
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated
      WBPaper00053550:daf-19(m86)_downregulated_L1
      WBPaper00056330:mrps-5(RNAi)_upregulated
    Interaction (36)
  Map_info: Map: V Position: 9.81605 Error: 0.000817
    Positive: Positive_clone: K05D4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene