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WormBase Tree Display for Gene: WBGene00010484

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Name Class

WBGene00010484SMapS_parentSequenceK01H12
IdentityVersion2
NameCGC_namedph-3Person_evidenceWBPerson237
Sequence_nameK01H12.1
Molecular_nameK01H12.1a
K01H12.1a.1
CE03453
K01H12.1b
CE44584
K01H12.1b.1
Other_nameCELE_K01H12.1Accession_evidenceNDBBX284604
Public_namedph-3
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:51WBPerson1971EventImportedInitial conversion from CDS class of WS125
218 Aug 2009 11:24:59WBPerson9133Name_changeCGC_namedph-3
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classdph
Allele (12)
StrainWBStrain00026526
RNASeq_FPKM (74)
GO_annotation00007431
00070278
00070279
00070280
00070281
00070282
00070283
00070284
Ortholog (33)
Structured_descriptionConcise_descriptiondph-3 encodes a small protein conserved in diverse eukaryotes, with a CSL motif (a probable zinc finger, sometimes found associated with the N-terminal domain of DnaJ protein); DPH-3 is probably a small subunit or ancillary protein of RNA polymerase II Elongator or of a hypothetical diphthamide synthase complex; DPH-3 is orthologous to mammalian DESR1 (diphtheria toxin and Pseudomonas exotoxin A sensitivity required gene 1) and S. cerevisiae KTI11; DESR1, and probably KTI11, enables the first step in posttranslational modification of histidine to dipthamide.Paper_evidenceWBPaper00005654
WBPaper00013055
WBPaper00013218
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated18 Aug 2009 00:00:00
Automated_descriptionPredicted to enable ferrous iron binding activity and iron chaperone activity. Predicted to be involved in protein histidyl modification to diphthamide and tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation. Located in nucleus. Is an ortholog of human DPH3 (diphthamide biosynthesis 3) and DPH3P1 (diphthamide biosynthesis 3 pseudogene 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_info (5)
Experimental_infoRNAi_resultWBRNAi00025838Inferred_automaticallyRNAi_primary
WBRNAi00027396Inferred_automaticallyRNAi_primary
WBRNAi00016414Inferred_automaticallyRNAi_primary
WBRNAi00025839Inferred_automaticallyRNAi_primary
WBRNAi00092977Inferred_automaticallyRNAi_primary
WBRNAi00115818Inferred_automaticallyRNAi_primary
WBRNAi00049641Inferred_automaticallyRNAi_primary
WBRNAi00033835Inferred_automaticallyRNAi_primary
Expr_patternExpr9502
Expr1019874
Expr1034578
Expr1153368
Expr2011049
Expr2029286
Drives_constructWBCnstr00031386
Construct_productWBCnstr00014067
WBCnstr00031386
Microarray_results (21)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00035211:age-1_vs_age-1_upregulated
WBPaper00037946:EGL-5_interacting
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038118:aak-2(gt33)_downregulated
WBPaper00038118:stress_downregulated_N2
WBPaper00038438:D.coniospora_12hr_upregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
WBPaper00040209:B.thuringiensis_upregulated_N2
WBPaper00041222:unc-120(st364)_upregulated
WBPaper00042561:smg-2(RNAi)_downregulated
WBPaper00044426:rotenone_24h_upregulated
WBPaper00044736:flat_dev_expression
WBPaper00044760:germline_specific
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
WBPaper00045314:S.aureus-induced_N2
WBPaper00045521:Gender_Neutral
WBPaper00048971:daf-16(mgDf50)_downregulated_L1
WBPaper00048988:neuron_expressed
WBPaper00049545:cco-1(RNAi)_downregulated
WBPaper00049545:jmjd-3.1(+)_downregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:pharynx_expressed
WBPaper00051039:germline_enriched
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053388:dauer_regulated_Cluster2
WBPaper00053599:oocyte_vs_mitosis_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055648:germline_expressed
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056826:SGP_biased
WBPaper00057041:spc-1(cas971)_downregulated
WBPaper00057041:unc-70(cas983)_downregulated
WBPaper00057288:Cold_downregulated_transcript
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058691:cfp-1(tm6369)_downregulated
WBPaper00058691:sin-3(tm1276)_downregulated
WBPaper00058725:sftb-1(cer6)_downregulated
WBPaper00060100:SiNP_downregulated_mRNA
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061274:hypergravity_15xg_downregulated
WBPaper00061340:PVQ_parent
WBPaper00061439:unc-30(ok613)_upregulated
WBPaper00061527:B0511.6_180-Y54E10BR.4_1509
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
WBPaper00064005:starvation_upregulated_N2_mRNA
WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064122:vulva_transcriptome
WBPaper00064871:hypoxia_downregulated_F1
WBPaper00065120:body-muscle-transcriptome
WBPaper00065835:Day11_vs_Day1_upregulated
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00066085:sin-3(tm1276)_downregulated
WBPaper00005475:Aging-regulated
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00032165:differentially_expressed_with_age_medoid_7
WBPaper00032948:StarveUp4
WBPaper00035084:embryo_enriched_AIN-2_IP
WBPaper00035084:L2_enriched_AIN-2_IP
WBPaper00035084:L3_enriched_AIN-2_IP
WBPaper00035084:L4_enriched_AIN-2_IP
WBPaper00035227:heat_shock_regulated
WBPaper00036286:Pattern_B
WBPaper00038427:lin-54_embryo_changed
WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
WBPaper00041174:environmental
WBPaper00041174:environmental_prime
WBPaper00041207:CE_dauer_up
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041960:daf-16_fasting_upregulated
WBPaper00041960:kgb-1_fasting_upregulated
WBPaper00041960:N2_fasting_upregulated
WBPaper00041960:N2_fasting_upregulated_anytime
WBPaper00042274:tbx-2(bx59)_upregulated
WBPaper00045263:isp-1(qm150)_downregulated
WBPaper00045263:nuo-6(qm200)_downregulated
WBPaper00047070:N2_starvation_upregulated
WBPaper00048624:hlh-25(ok1710)_downregulated
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
[cgc5767]:cluster_2
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(83_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
Interaction (49)
Map_infoMapIVPosition4.37903Error0.001128
PositivePositive_cloneK01H12Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00027309
WBPaper00036232
WBPaper00038444
WBPaper00038491
WBPaper00055090
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene