WormBase Tree Display for Gene: WBGene00010453
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| WBGene00010453 | SMap | S_parent | Sequence | K01B6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | fozi-1 | Person_evidence | WBPerson260 | |||||
| Sequence_name | K01B6.1 | ||||||||
| Molecular_name | K01B6.1 | ||||||||
| K01B6.1.1 | |||||||||
| CE00238 | |||||||||
| K01B6.1.2 | |||||||||
| K01B6.1.3 | |||||||||
| Other_name | CELE_K01B6.1 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | fozi-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:51 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 25 Jan 2005 16:28:46 | WBPerson2970 | Name_change | CGC_name | fozi-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | fozi | ||||||||
| Allele (221) | |||||||||
| Strain | WBStrain00026333 | ||||||||
| WBStrain00026337 | |||||||||
| WBStrain00029382 | |||||||||
| WBStrain00029385 | |||||||||
| WBStrain00029394 | |||||||||
| WBStrain00029403 | |||||||||
| WBStrain00031854 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (37) | |||||||||
| Paralog | WBGene00021698 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Structured_description | Concise_description | fozi-1 encodes an unusual zinc-finger protein that has two C2H2 zinc-finger motifs that probably mediate transcriptional regulation along with a glutamine-rich region and a vestigial formin homology 2 (FH2) domain that has lost its ability to polymerize actin but retained its ability to dimerize; during postembryonic development, FOZI-1 acts with MAB-5 and redundantly with HLH-1/CeMyoD to autonomously specify coelomocyte and striated body wall muscle fates; in addition, fozi-1 is required for the fully asymmetrical phenotypic distinction of ASER cells from ASEL cells; fozi-1 mutant animals variably express flp-4, gcy-6, gcy-7 and lim-6, genes normally restricted to ASEL, in ASER as well, while maintaining expression of ASER-specific genes; ectopic FOZI-1 expression in ASEL can suppress lim-6 expression; fozi-1 genetically interacts with several regulatory proteins and miRNAs; FOZI-1 is a nuclear protein that is expressed in neuronal lineages beginning at the 2-fold stage of embryogenesis, and then in neurons and cells derived from the M mesoblast during larval development; expression in the M lineage corresponds to cells that will generate coelomocytes and body wall muscles and is not seen in the sex myoblasts (SMs); FOZI-1 expression in the M lineage requires the Hox co-factor CEH-20. | Paper_evidence | WBPaper00005068 | |||||
| WBPaper00005654 | |||||||||
| WBPaper00012788 | |||||||||
| WBPaper00012882 | |||||||||
| WBPaper00012897 | |||||||||
| WBPaper00013003 | |||||||||
| WBPaper00028375 | |||||||||
| WBPaper00028855 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 07 May 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable actin filament binding activity. Involved in mesodermal cell fate specification and positive regulation of mesodermal cell fate specification. Located in nucleus. Expressed in several structures, including M.dla; amphid neurons; body wall muscle cell from M lineage; coelomocyte; and somatic nervous system. Is an ortholog of human FMNL1 (formin like 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | K01B6.1 | |||||||
| Corresponding_transcript | K01B6.1.1 | ||||||||
| K01B6.1.2 | |||||||||
| K01B6.1.3 | |||||||||
| Other_sequence | Name_isotig05918 | ||||||||
| JI172908.1 | |||||||||
| Oden_isotig26319 | |||||||||
| Associated_feature (24) | |||||||||
| Transcription_factor | WBTranscriptionFactor001032 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00033810 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00092976 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00006025 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101794 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00049599 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00016382 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101793 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00065443 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr64 | ||||||||
| Expr3954 | |||||||||
| Expr3955 | |||||||||
| Expr8278 | |||||||||
| Expr8279 | |||||||||
| Expr1010801 | |||||||||
| Expr1034559 | |||||||||
| Expr1153329 | |||||||||
| Expr2011874 | |||||||||
| Expr2030112 | |||||||||
| Drives_construct | WBCnstr00011778 | ||||||||
| WBCnstr00018898 | |||||||||
| WBCnstr00031409 | |||||||||
| Construct_product | WBCnstr00011778 | ||||||||
| WBCnstr00011779 | |||||||||
| WBCnstr00018898 | |||||||||
| WBCnstr00031409 | |||||||||
| Antibody | WBAntibody00001187 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (201) | |||||||||
| Interaction (68) | |||||||||
| Map_info | Map | III | Position | 0.391746 | Error | 0.007582 | |||
| Positive | Positive_clone | K01B6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5074 | |||||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
