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WormBase Tree Display for Gene: WBGene00010453

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Name Class

WBGene00010453SMapS_parentSequenceK01B6
IdentityVersion2
NameCGC_namefozi-1Person_evidenceWBPerson260
Sequence_nameK01B6.1
Molecular_nameK01B6.1
K01B6.1.1
CE00238
K01B6.1.2
K01B6.1.3
Other_nameCELE_K01B6.1Accession_evidenceNDBBX284603
Public_namefozi-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:51WBPerson1971EventImportedInitial conversion from CDS class of WS125
225 Jan 2005 16:28:46WBPerson2970Name_changeCGC_namefozi-1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classfozi
AlleleWBVar00051607Inferred_automaticallyFrom strain object: LW257
WBVar00092438Inferred_automaticallyFrom strain object: RB1152
WBVar00094900
WBVar01918660
WBVar01409107
WBVar01500260
WBVar00305411
WBVar01944706
WBVar01447463
WBVar01723129
WBVar01447464
WBVar01447465
WBVar01447468
WBVar01447469
WBVar01447470
WBVar01447471
WBVar00849596
WBVar00849597
WBVar00849598
WBVar00849599
WBVar00849600
WBVar01990320
WBVar00215458
WBVar01990321
WBVar00215460
WBVar02051182
WBVar00849601
WBVar00215462
WBVar00320249
WBVar00849602
WBVar01990322
WBVar00849603
WBVar00320250
WBVar00320251
WBVar00849604
WBVar00849605
WBVar00849606
WBVar00051597
WBVar00849607
WBVar00849608
WBVar00309939
WBVar00849609
WBVar00309940
WBVar00051602
WBVar00849610
WBVar00849611
WBVar00849612
WBVar00849613
WBVar00094799
WBVar02049716
WBVar00849614
WBVar00849615
WBVar00849616
WBVar00051612
WBVar00849617
WBVar01838359
WBVar00849618
WBVar00849619
WBVar01838360
WBVar00849620
WBVar01401671
WBVar02079987
WBVar00849621
WBVar00849622
WBVar00849623
WBVar00849624
WBVar00849625
WBVar00849626
WBVar00849627
WBVar01995628
WBVar00849628
WBVar01995629
WBVar00849629
WBVar00849630
WBVar00849631
WBVar00849632
WBVar00299836
WBVar00299837
WBVar00849633
WBVar01499774
WBVar00299838
WBVar00849634
WBVar02144150
WBVar00849635
WBVar00299839
WBVar00849636
WBVar00849637
WBVar00849638
WBVar00849639
WBVar02053465
WBVar00070628
WBVar00849640
WBVar00849641
WBVar00094838
WBVar00849642
WBVar00849643
WBVar00070633
WBVar00849644
WBVar00849645
WBVar01416202
WBVar00849646
WBVar00849647
WBVar01825500
WBVar00070638
WBVar00849648
WBVar00094855
WBVar00249602
WBVar00094856
WBVar00849649
WBVar02132496
WBVar00849650
WBVar00094857
WBVar00849651
WBVar00094858
WBVar00070643
WBVar00849652
WBVar00094859
WBVar00849653
WBVar01332002
WBVar01332007
WBVar00849654
WBVar00070648
WBVar00849655
WBVar00849656
WBVar00849657
WBVar00849658
WBVar00564605
WBVar00564606
WBVar00849659
WBVar00070653
WBVar00849660
WBVar00849661
WBVar00849662
WBVar00261225
WBVar00849663
WBVar00070658
WBVar00849664
WBVar00849665
WBVar00849666
WBVar00405032
WBVar00070663
WBVar00094879
WBVar00405033
WBVar00316514
WBVar01267020
WBVar00316515
WBVar00405034
WBVar00094881
WBVar01267022
WBVar00405035
WBVar00316516
WBVar01541926
WBVar00070668
WBVar00405036
WBVar00405037
WBVar00405038
WBVar01645837
WBVar00405039
WBVar01645838
WBVar00405040
WBVar00405041
WBVar00405042
WBVar01629289
WBVar00405043
WBVar01629290
WBVar00405044
WBVar00405045
WBVar01629291
WBVar00405046
WBVar01629292
WBVar00405047
WBVar01629293
WBVar00405048
WBVar01629294
WBVar02094222
WBVar01629295
WBVar00405049
WBVar00405050
WBVar00094899
WBVar01629296
WBVar01629297
WBVar00405051
WBVar01629298
WBVar00405052
WBVar00602747
WBVar00405053
WBVar01629299
WBVar00405054
WBVar01629300
WBVar00405055
WBVar00405056
WBVar00405057
WBVar00405058
WBVar00405059
WBVar01497994
WBVar00100899
WBVar00405060
WBVar00405061
WBVar00405062
WBVar01939514
WBVar00306639
WBVar00322090
WBVar00322091
WBVar00322092
WBVar00094932
WBVar00094934
WBVar00298468
WBVar02069652
WBVar01607199
WBVar01607200
WBVar01480176
WBVar00276846
WBVar00276847
WBVar00313143
WBVar00313144
WBVar00307940
WBVar00307941
WBVar00254669
WBVar00301003
WBVar01852329
WBVar01489762
StrainWBStrain00026333
WBStrain00026337
WBStrain00029382
WBStrain00029385
WBStrain00029394
WBStrain00029403
WBStrain00031854
RNASeq_FPKM (74)
GO_annotation (13)
Ortholog (37)
ParalogWBGene00021698Caenorhabditis elegansFrom_analysisTreeFam
Structured_descriptionConcise_descriptionfozi-1 encodes an unusual zinc-finger protein that has two C2H2 zinc-finger motifs that probably mediate transcriptional regulation along with a glutamine-rich region and a vestigial formin homology 2 (FH2) domain that has lost its ability to polymerize actin but retained its ability to dimerize; during postembryonic development, FOZI-1 acts with MAB-5 and redundantly with HLH-1/CeMyoD to autonomously specify coelomocyte and striated body wall muscle fates; in addition, fozi-1 is required for the fully asymmetrical phenotypic distinction of ASER cells from ASEL cells; fozi-1 mutant animals variably express flp-4, gcy-6, gcy-7 and lim-6, genes normally restricted to ASEL, in ASER as well, while maintaining expression of ASER-specific genes; ectopic FOZI-1 expression in ASEL can suppress lim-6 expression; fozi-1 genetically interacts with several regulatory proteins and miRNAs; FOZI-1 is a nuclear protein that is expressed in neuronal lineages beginning at the 2-fold stage of embryogenesis, and then in neurons and cells derived from the M mesoblast during larval development; expression in the M lineage corresponds to cells that will generate coelomocytes and body wall muscles and is not seen in the sex myoblasts (SMs); FOZI-1 expression in the M lineage requires the Hox co-factor CEH-20.Paper_evidenceWBPaper00005068
WBPaper00005654
WBPaper00012788
WBPaper00012882
WBPaper00012897
WBPaper00013003
WBPaper00028375
WBPaper00028855
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated07 May 2007 00:00:00
Automated_descriptionPredicted to enable actin filament binding activity. Involved in mesodermal cell fate specification and positive regulation of mesodermal cell fate specification. Located in nucleus. Expressed in several structures, including M.dla; amphid neurons; body wall muscle cell from M lineage; coelomocyte; and somatic nervous system. Is an ortholog of human FMNL1 (formin like 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSK01B6.1
Corresponding_transcriptK01B6.1.1
K01B6.1.2
K01B6.1.3
Other_sequenceName_isotig05918
JI172908.1
Oden_isotig26319
Associated_feature (24)
Transcription_factorWBTranscriptionFactor001032
Experimental_infoRNAi_resultWBRNAi00033810Inferred_automaticallyRNAi_primary
WBRNAi00092976Inferred_automaticallyRNAi_primary
WBRNAi00006025Inferred_automaticallyRNAi_primary
WBRNAi00101794Inferred_automaticallyRNAi_primary
WBRNAi00049599Inferred_automaticallyRNAi_primary
WBRNAi00016382Inferred_automaticallyRNAi_primary
WBRNAi00101793Inferred_automaticallyRNAi_primary
WBRNAi00065443Inferred_automaticallyRNAi_primary
Expr_patternExpr64
Expr3954
Expr3955
Expr8278
Expr8279
Expr1010801
Expr1034559
Expr1153329
Expr2011874
Expr2030112
Drives_constructWBCnstr00011778
WBCnstr00018898
WBCnstr00031409
Construct_productWBCnstr00011778
WBCnstr00011779
WBCnstr00018898
WBCnstr00031409
AntibodyWBAntibody00001187
Microarray_results (19)
Expression_cluster (201)
Interaction (68)
Map_infoMapIIIPosition0.391746Error0.007582
PositivePositive_cloneK01B6Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point5074
Pseudo_map_position
Reference (14)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene