WormBase Tree Display for Gene: WBGene00010160
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WBGene00010160 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | png-1 | Person_evidence | WBPerson114 | |||||
Sequence_name | F56G4.5 | ||||||||
Molecular_name | F56G4.5 | ||||||||
F56G4.5.1 | |||||||||
CE23786 | |||||||||
Other_name | bam-1 | ||||||||
CELE_F56G4.5 | Accession_evidence | NDB | BX284601 | ||||||
Public_name | png-1 | ||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 26 May 2004 16:54:51 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
2 | 15 Mar 2007 17:00:31 | WBPerson2970 | Name_change | CGC_name | png-1 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | png | ||||||||
Allele (152) | |||||||||
Strain | WBStrain00001991 | ||||||||
WBStrain00030529 | |||||||||
WBStrain00032150 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (25) | |||||||||
Contained_in_operon | CEOP1652 | ||||||||
Ortholog (35) | |||||||||
Paralog (15) | |||||||||
Structured_description | Concise_description | png-1 encodes a peptide-N[4]-(N-acetyl-beta-D-glucosaminyl) asparagineamidase (i.e., peptide:N-glycanase or PNGase) orthologous to buddingyeast PNG1 and human NGLY1; PNG-1 is atypically organized, with anN-terminal thioredoxin-like domain, a central transglutaminase domain,and a C-terminal DUF750 domain, while lacking the PUB domain found inmammalian or insect PNGases; both in vitro and in vivo, PNG-1 shows bothprotein disulfide reductase and PNGase activities, which require itsN-terminal and central domains respectively; PNG-1 has PNGase activityon denatured but not natively folded RNAse B, and releases both highmannose- and sialo-complex-type N-glycans from glycopeptides anddenatured glycoproteins; in vivo, the png-1(cy8) mutation C251Y(predicted to destroy the PNGase active site) abolishes PNGase activitywhile leaving PNG-1's reductase activity intact; conversely, PNG-1'sreductase activity is abolished by the dual missense mutation C34S/C37S,which alters its predicted N-terminal active site; by orthology, PNG-1is expected to aid proteasomal degradation of misfolded proteins; PNG-1activity is inhibited by Zn(2+) and the caspase inhibitor z-VAD-fmk, butnot by EDTA; PNG-1 is expressed in renal gland cells and intestine;although W04G5.5 and Y50D4B.7 have some similarity to thetransglutaminase domain of PNG-1, they lack a predicted catalytic triadactive site. | Paper_evidence | WBPaper00006525 | |||||
WBPaper00029398 | |||||||||
WBPaper00029436 | |||||||||
Curator_confirmed | WBPerson567 | ||||||||
Date_last_updated | 05 Jun 2007 00:00:00 | ||||||||
Automated_description | Enables peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity and protein-disulfide reductase (NAD(P)) activity. Involved in cell redox homeostasis; negative regulation of collateral sprouting; and ubiquitin-dependent ERAD pathway. Located in cytoplasm. Expressed in body wall musculature; gonad; neurons; pharynx; and vulva. Human ortholog(s) of this gene implicated in NGLY1-deficiency. Is an ortholog of human NGLY1 (N-glycanase 1). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0060728 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17646) | ||||
Molecular_info | Corresponding_CDS | F56G4.5 | |||||||
Corresponding_transcript | F56G4.5.1 | ||||||||
Other_sequence | EX539623.1 | ||||||||
Acan_isotig11424 | |||||||||
CBC00976_1 | |||||||||
MAC00959_1 | |||||||||
ACC06749_1 | |||||||||
PT03448 | |||||||||
SR04827 | |||||||||
Dviv_isotig29313 | |||||||||
MA01872 | |||||||||
Associated_feature | WBsf656941 | ||||||||
WBsf985278 | |||||||||
WBsf1010709 | |||||||||
WBsf218531 | |||||||||
Experimental_info | RNAi_result | WBRNAi00116961 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00076493 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00048764 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00032982 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00004720 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr6232 | ||||||||
Expr8899 | |||||||||
Expr8900 | |||||||||
Expr1024009 | |||||||||
Expr1034438 | |||||||||
Expr1152511 | |||||||||
Expr2014983 | |||||||||
Expr2033218 | |||||||||
Drives_construct | WBCnstr00002775 | ||||||||
WBCnstr00013592 | |||||||||
WBCnstr00013594 | |||||||||
Construct_product | WBCnstr00013594 | ||||||||
Microarray_results (21) | |||||||||
Expression_cluster (85) | |||||||||
Interaction (21) | |||||||||
Map_info | Map | I | Position | 7.95669 | Error | 0.002444 | |||
Positive | Positive_clone | F56G4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference (17) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |