WormBase Tree Display for Gene: WBGene00010054

WBGene00010054 SMap: S_parent: Sequence: F54D5
  Identity: Version: 2
    Name: CGC_name: gtf-2E2
      Sequence_name: F54D5.11
      Molecular_name: F54D5.11
        F54D5.11.1
        CE26813
      Other_name: CELE_F54D5.11 Accession_evidence: NDB BX284602
      Public_name: gtf-2E2
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:51 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 05 Jul 2018 12:31:10 WBPerson1983 Name_change: CGC_name: gtf-2E2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: gtf
    Allele (27)
    RNASeq_FPKM (74)
    GO_annotation (14)
    Contained_in_operon: CEOP2556
    Ortholog (35)
    Structured_description: Concise_description: F54D5.11 encodes the C. elegans ortholog of the TFIIE beta subunit; when expressed in vitro with the TFIIE alpha subunit encoded by ZK550.4, the protein product of F54D5.11 supports transcription initiation; the protein products of F54D5.11 and ZK550.4 physically interact in vitro. Paper_evidence: WBPaper00004472
          Curator_confirmed: WBPerson1843
          Date_last_updated: 28 Feb 2011 00:00:00
      Automated_description: Enables RNA polymerase II complex binding activity. Involved in transcription initiation at RNA polymerase II promoter. Part of transcription factor TFIIE complex. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 6. Is an ortholog of human GTF2E2 (general transcription factor IIE subunit 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111872 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4651)
  Molecular_info: Corresponding_CDS: F54D5.11
    Corresponding_CDS_history: F54D5.11:wp42
    Corresponding_transcript: F54D5.11.1
    Other_sequence (35)
    Associated_feature: WBsf650589
      WBsf223957
    Transcription_factor: WBTranscriptionFactor000539
  Experimental_info: RNAi_result: WBRNAi00048308 Inferred_automatically: RNAi_primary
      WBRNAi00025625 Inferred_automatically: RNAi_primary
      WBRNAi00111734 Inferred_automatically: RNAi_primary
      WBRNAi00002324 Inferred_automatically: RNAi_primary
      WBRNAi00071227 Inferred_automatically: RNAi_primary
      WBRNAi00008854 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1027491
      Expr1034385
      Expr1152109
      Expr2004147
      Expr2022371
    Antibody: WBAntibody00000332
    Microarray_results (20)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037682:sma-2_upregulated
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00041222:unc-120(st364)_downregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00045420:fertilization_upregulated_protein
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:daf-16(mu86)_upregulated_neuron
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00050412:cco-1(RNAi)_downregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00051404:alg-2(ok304)_upregulated
      WBPaper00051404:alg-5(ram2)_upregulated
      WBPaper00051558:aging_regulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055648:germline_expressed
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056284:ints-11(RNAi)_upregulated
      WBPaper00057254:MWCNT_upregulated_mRNA
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058725:sftb-1(cer6)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061527:F54E7.8-orc-5_6376
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064716:paraquat_upregulated
      WBPaper00064735:bet-1B(OE)mys-1(RNAi)_vs_mys-1(RNAi)_downregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065272:dhgd-1(tm6671)_downregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      WBPaper00025032:cluster_3
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00030985:Photorhabdus_luminescens_upregulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036286:Pattern_B
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:cluster_8
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:Cluster_E
    Interaction (48)
  Map_info: Map: II Position: 3.74492
    Positive: Positive_clone: F54D5 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00004472
    WBPaper00027309
    WBPaper00029038
    WBPaper00038491
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene