klf-2 encodes one of three C. elegans Kruppel-like transcription factors; KLF-2 is homologous to human WT1, which when mutated leads to Wilms tumour (OMIM:194070).
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of gene expression and regulation of lipid metabolic process. Predicted to be located in nucleus. Expressed in intestine. Human ortholog(s) of this gene implicated in intracranial aneurysm. Is an ortholog of human KLF5 (KLF transcription factor 5).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.