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WormBase Tree Display for Gene: WBGene00009865

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Name Class

WBGene00009865SMapS_parentSequenceCHROMOSOME_I
IdentityVersion1
NameSequence_nameF49B2.6
Molecular_nameF49B2.6
F49B2.6.1
CE40456
Other_nameY105E8A.aCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
CELE_F49B2.6Accession_evidenceNDBBX284601
Public_nameF49B2.6
DB_infoDatabaseAceViewgene1O931
WormQTLgeneWBGene00009865
WormFluxgeneWBGene00009865
NDBlocus_tagCELE_F49B2.6
PanthergeneCAEEL|WormBase=WBGene00009865|UniProtKB=G5EGH4
familyPTHR11533
NCBIgene173297
RefSeqproteinNM_061102.5
TrEMBLUniProtAccG5EGH4
UniProt_GCRPUniProtAccG5EGH4
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:50WBPerson1971EventImportedInitial conversion from CDS class of WS125
StatusLive
Gene_infoBiotypeSO:0001217
Allele (210)
StrainWBStrain00055195
RNASeq_FPKM (74)
GO_annotation (16)
Ortholog (64)
Paralog (13)
Structured_descriptionAutomated_descriptionPredicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including severe acute respiratory syndrome; severe pre-eclampsia; and uterine disease (multiple). Is an ortholog of human ERAP1 (endoplasmic reticulum aminopeptidase 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:2871Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:18173)
DOID:2945Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:500)
DOID:2893Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:18173)
DOID:9352Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6656)
DOID:13129Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:18173,HGNC:29499,HGNC:6656)
DOID:127Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6656)
DOID:4450Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6656)
DOID:8488Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6656)
DOID:1612Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6656)
Molecular_infoCorresponding_CDSF49B2.6
Corresponding_CDS_historyF49B2.6:wp165
Corresponding_transcriptF49B2.6.1
Other_sequenceRSC03442_1
ACC27304_1
Oden_isotig21442
Dviv_isotig05052
JI166885.1
Dviv_isotig05053
JO471077.1
RS09292
Associated_feature (15)
Experimental_infoRNAi_resultWBRNAi00047794Inferred_automaticallyRNAi_primary
WBRNAi00003723Inferred_automaticallyRNAi_primary
WBRNAi00026540Inferred_automaticallyRNAi_primary
WBRNAi00026541Inferred_automaticallyRNAi_primary
WBRNAi00004468Inferred_automaticallyRNAi_primary
Expr_patternExpr1028980
Expr1151628
Expr2003904
Expr2022126
Microarray_results (26)
Expression_clusterWBPaper00030922:glycosylated_protein
WBPaper00033065:cyc-1(RNAi)_downregulated
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:coelomocytes_embryo_enriched
WBPaper00037950:coelomocytes_embryo_SelectivelyEnriched
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_embryo_enriched
WBPaper00037950:GABAergic-motor-neurons_embryo_SelectivelyEnriched
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00038289:oocyte_protein
WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00040221:DAF-12_target_ALF4
WBPaper00042215:wdr-23(tm1817)_upregulated
WBPaper00042561:smg-2(RNAi)_upregulated
WBPaper00042561:smgl-1(RNAi)_upregulated
WBPaper00042561:smgl-2(RNAi)_upregulated
WBPaper00044037:eat-2_upregulated
WBPaper00044736:oscillating_dev_expression
WBPaper00045017:blmp-1(tm548)_upregulated
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045861:ash-2(tm1095)_upregulated
WBPaper00045861:set-2(ok952)_upregulated
WBPaper00045861:wdr-5(ok1417)_upregulated
WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049377:MWCNT_upregulated
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00050080:rbr-2(tm3141)_downregulated
WBPaper00050370:dpy-21(e428)_L3_upregulated
WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
WBPaper00050488:20C_vs_25C_regulated_N2_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050990:hypodermis_enriched
WBPaper00050990:hypodermis_expressed
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053388:dauer_regulated_Cluster1
WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
WBPaper00053771:down_by_skn-1(RNAi)_at_24h-NaCl
WBPaper00053771:down_by_skn-1(RNAi)_at_dpy-7(e88)
WBPaper00055013:spt-16(RNAi)_upregulated
WBPaper00055354:eat-2(ad1116)_upregulated
WBPaper00055354:Rapamycin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Psora_upregulated
WBPaper00055626:pry-1(mu38)_downregulated
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056471:S.aureus-4h_upregulated_N2
WBPaper00056826:hmc_biased
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057068:ints-4(RNAi)_upregulated
WBPaper00057068:ints-4(RNAi)_upregulated_Cadmium
WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058691:cfp-1(tm6369)_upregulated
WBPaper00058691:set-2(bn129)_upregulated
WBPaper00058691:sin-3(tm1276)_upregulated
WBPaper00058969:RIS_depleted
WBPaper00059117:B.subtilis_upregulated
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059421:daf-1(m40)_upregulated
WBPaper00059421:daf-3(mgDf90)_downregulated
WBPaper00059566:wdr-23(mac32)_upregulated
WBPaper00060014:set-2(zr2012)_downregulated
WBPaper00060100:SiNP_upregulated_mRNA
WBPaper00060459:bcat-1(RNAi)_upregulated
WBPaper00060526:plp-1(ok2155)_upregulated
WBPaper00060909:atfs-1(et18)_downregulated
WBPaper00061274:microgravity_downregulated
WBPaper00061340:Arcade_cell_anterior_and_posterior
WBPaper00061340:g1A_parent
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061479:mep-1(ne4629)_upregulated
WBPaper00061479:ubc-9(ne4833)_upregulated
WBPaper00061527:sre-33-ZK1025.1_8337
WBPaper00061527:T16H12.9-kin-9_20752
WBPaper00061995:mter-4(syb3662syb3403)_downregulated
WBPaper00062156:jmjd-5(zr1234)_upregulated
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00064005:starvation_downregulated_N2_mRNA
WBPaper00064130:Beta-Amyloid_upregulated_protein
WBPaper00064156:lbp-3(overexpress)_upregulated
WBPaper00064156:lipl-4(overexpress)_upregulated
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064315:mes-3(bn199)_downregulated_PGCs
WBPaper00064315:met-1(bn200)_downregulated_PGCs
WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
WBPaper00064632:daf-2(e1370)_downregulated_intestine
WBPaper00064721:fasn-1(g14)_downregulated_starved
WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
WBPaper00065158:25C_vs_15C_downregulated_WholeAnimal
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
WBPaper00065749:Heat-Shock_downregulated_N2
WBPaper00065759:dot-1.1(knu339)_upregulated
WBPaper00065835:Day5_vs_Day1_downregulated
WBPaper00065841:23_0
WBPaper00065841:24_0
WBPaper00065841:24_1
WBPaper00065841:26_0
WBPaper00065841:26_1
WBPaper00065841:26_2
WBPaper00065841:51_0
WBPaper00065841:86_0
WBPaper00065993:glp-1(e2141)_upregulated
cgc4489_group_18
cgc4489_group_20
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00036123:Fluoranthene_regulated
WBPaper00040821:Au-NP_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00045673:colistin_downregulated
WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated
WBPaper00047070:N2_UV_upregulated
WBPaper00047070:xpa-1_UV_upregulated
WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
InteractionWBInteraction000460229
Map_info (2)
ReferenceWBPaper00038491
WBPaper00055090
MethodGene