cwp-5 encodes a novel, single-pass Type I transmembrane protein; CWP-5 is required for the response step of male mating behavior, acting in the same pathway as the polycystin complex members, LOV-1 and PKD-2; specifically, CWP-5 appears to function to negatively regulate latent, obstructive signaling by LOV-1 or PKD-2; CWP-5 is expressed in 21 male-specific sensory neurons, where it localizes to cilia, dendrites, and the cell soma; CWP-5 localization to cilia and dendrites depends upon LOV-1 activity.
Involved in neuronal signal transduction and response to hermaphrodite contact. Located in cell body; dendrite; and non-motile cilium. Expressed in CEM; HOB; and ray neuron type B.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.