WormBase Tree Display for Gene: WBGene00009813
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WBGene00009813 | SMap | S_parent | Sequence | F47B10 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | haly-1 | Paper_evidence | WBPaper00038278 | |||
Person_evidence | WBPerson341 | ||||||
Sequence_name | F47B10.2 | ||||||
Molecular_name | F47B10.2 | ||||||
F47B10.2.1 | |||||||
CE03352 | |||||||
Other_name | CELE_F47B10.2 | Accession_evidence | NDB | BX284606 | |||
Public_name | haly-1 | ||||||
DB_info | Database (13) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | haly | ||||||
Allele (44) | |||||||
Strain | WBStrain00040582 | ||||||
WBStrain00040583 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (13) | |||||||
Ortholog (30) | |||||||
Structured_description | Concise_description | haly-1 encodes a histidine ammonia lyase orthologous to the human gene HISTIDASE (HAL; OMIM:235800); HALY-1 is required in C. elegans for conversion of histidine to urocanic acid via reductive deamination; loss-of-function mutations in haly-1 result in protection against zinc and nickel toxicity owing to increased levels of metal-chelating histidine; genetic studies suggest that haly-1 functions in parallel to members of the cation diffusion facilitator family of zinc transporters encodes by cdf-1, cdf-2, and sur-7 to modulate zinc sensitivity; haly-1 mRNA levels do not vary under different dietary zinc conditions. | Paper_evidence | WBPaper00031911 | |||
WBPaper00038278 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson1823 | |||||||
WBPerson567 | |||||||
Date_last_updated | 04 Apr 2011 00:00:00 | ||||||
Automated_description | Predicted to enable histidine ammonia-lyase activity. Involved in histidine catabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in histidinemia. Is an ortholog of human HAL (histidine ammonia-lyase). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0060168 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4806) | ||
Molecular_info | Corresponding_CDS | F47B10.2 | |||||
Corresponding_transcript | F47B10.2.1 | ||||||
Other_sequence (79) | |||||||
Associated_feature | WBsf654368 | ||||||
WBsf237907 | |||||||
WBsf237908 | |||||||
Experimental_info | RNAi_result | WBRNAi00015146 | Inferred_automatically | RNAi_primary | |||
WBRNAi00047595 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00032403 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Chronogram1244 | ||||||
Expr6096 | |||||||
Expr1025610 | |||||||
Expr1034288 | |||||||
Expr1151431 | |||||||
Expr2012363 | |||||||
Expr2030599 | |||||||
Drives_construct | WBCnstr00003174 | ||||||
WBCnstr00020173 | |||||||
WBCnstr00031899 | |||||||
Construct_product | WBCnstr00020173 | ||||||
WBCnstr00031899 | |||||||
Microarray_results (22) | |||||||
Expression_cluster (225) | |||||||
Interaction (19) | |||||||
Map_info | Map | X | Position | 2.67922 | |||
Positive | Positive_clone | F47B10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference | WBPaper00031911 | ||||||
WBPaper00038278 | |||||||
WBPaper00038491 | |||||||
WBPaper00039078 | |||||||
WBPaper00045887 | |||||||
WBPaper00055090 | |||||||
WBPaper00063976 | |||||||
WBPaper00064232 | |||||||
WBPaper00065140 | |||||||
WBPaper00065331 | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |