WormBase Tree Display for Gene: WBGene00009813
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| WBGene00009813 | SMap | S_parent | Sequence | F47B10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | haly-1 | Paper_evidence | WBPaper00038278 | |||||
| Person_evidence | WBPerson341 | ||||||||
| Sequence_name | F47B10.2 | ||||||||
| Molecular_name | F47B10.2 | ||||||||
| F47B10.2.1 | |||||||||
| CE03352 | |||||||||
| Other_name | CELE_F47B10.2 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | haly-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:50 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 12 Apr 2011 11:48:32 | WBPerson2970 | Name_change | CGC_name | haly-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | haly | ||||||||
| Allele (44) | |||||||||
| Strain | WBStrain00040582 | ||||||||
| WBStrain00040583 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (30) | |||||||||
| Structured_description | Concise_description | haly-1 encodes a histidine ammonia lyase orthologous to the human gene HISTIDASE (HAL; OMIM:235800); HALY-1 is required in C. elegans for conversion of histidine to urocanic acid via reductive deamination; loss-of-function mutations in haly-1 result in protection against zinc and nickel toxicity owing to increased levels of metal-chelating histidine; genetic studies suggest that haly-1 functions in parallel to members of the cation diffusion facilitator family of zinc transporters encodes by cdf-1, cdf-2, and sur-7 to modulate zinc sensitivity; haly-1 mRNA levels do not vary under different dietary zinc conditions. | Paper_evidence | WBPaper00031911 | |||||
| WBPaper00038278 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 04 Apr 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable histidine ammonia-lyase activity. Involved in histidine catabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in histidinemia. Is an ortholog of human HAL (histidine ammonia-lyase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060168 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4806) | ||||
| Molecular_info | Corresponding_CDS | F47B10.2 | |||||||
| Corresponding_transcript | F47B10.2.1 | ||||||||
| Other_sequence (79) | |||||||||
| Associated_feature | WBsf654368 | ||||||||
| WBsf237907 | |||||||||
| WBsf237908 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00015146 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00047595 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00032403 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram1244 | ||||||||
| Expr6096 | |||||||||
| Expr1025610 | |||||||||
| Expr1034288 | |||||||||
| Expr1151431 | |||||||||
| Expr2012363 | |||||||||
| Expr2030599 | |||||||||
| Drives_construct | WBCnstr00003174 | ||||||||
| WBCnstr00020173 | |||||||||
| WBCnstr00031899 | |||||||||
| Construct_product | WBCnstr00020173 | ||||||||
| WBCnstr00031899 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (225) | |||||||||
| Interaction (19) | |||||||||
| Map_info | Map | X | Position | 2.67922 | |||||
| Positive | Positive_clone | F47B10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (10) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
