WormBase Tree Display for Gene: WBGene00007918
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| WBGene00007918 | SMap | S_parent | Sequence | C34C6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | sphk-1 | Person_evidence | WBPerson6511 | |||||
| WBPerson590 | |||||||||
| Sequence_name | C34C6.5 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | tag-274 | ||||||||
| CELE_C34C6.5 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | sphk-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:48 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 22 Apr 2005 11:55:18 | WBPerson2970 | Name_change | CGC_name | tag-274 | ||||
| 3 | 03 Dec 2007 11:45:57 | WBPerson2970 | Name_change | CGC_name | sphk-1 | ||||
| Other_name | tag-274 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sphk | ||||||||
| Allele (42) | |||||||||
| Strain | WBStrain00036171 | ||||||||
| WBStrain00005455 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (47) | |||||||||
| Contained_in_operon | CEOP2384 | ||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00020398 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00018674 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | sphk-1 encodes a sphingosine kinase orhtologous to the mammalian sphingosine kinases (SphK1 and SphK2); SPHK-1 activity is required, primarily in neurons, for promoting neurotransmitter release from synaptic vesicles at neuromuscular junctions; sphk-1 is expressedin the majority of cholinergic and GABAergic neurons, as well as in body wall muscle, intestine, and hypodermis; SPHK-1 localizes to discrete subsynaptic regions at presynaptic terminals; SPHK-1 abundance at presynaptic regions is regulated by a muscarinic signaling pathway that includes the muscarinc acetylcholine receptor GAR-3, the G protein subunit EGL-30, and the Trio Rho/GEF UNC-73. | Paper_evidence | WBPaper00041106 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 24 Oct 2013 00:00:00 | ||||||||
| Automated_description | Predicted to enable D-erythro-sphingosine kinase activity and acetyltransferase activity. Involved in mitochondrial unfolded protein response; positive regulation of acetylcholine secretion, neurotransmission; and regulation of locomotion. Located in several cellular components, including mitochondrion; neuronal cell body; and presynaptic periactive zone. Expressed in several structures, including body wall musculature; excretory canal; intestine; linker cell; and neurons. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is an ortholog of human SPHK1 (sphingosine kinase 1) and SPHK2 (sphingosine kinase 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11240) | ||||
| Molecular_info | Corresponding_CDS | C34C6.5a | |||||||
| C34C6.5b | |||||||||
| C34C6.5c | |||||||||
| C34C6.5d | |||||||||
| Corresponding_transcript | C34C6.5a.1 | ||||||||
| C34C6.5b.1 | |||||||||
| C34C6.5c.1 | |||||||||
| C34C6.5d.1 | |||||||||
| Other_sequence (17) | |||||||||
| Associated_feature | WBsf650356 | ||||||||
| WBsf650357 | |||||||||
| WBsf665256 | |||||||||
| WBsf717740 | |||||||||
| WBsf988798 | |||||||||
| WBsf223536 | |||||||||
| WBsf223537 | |||||||||
| Experimental_info | RNAi_result (20) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00015023 | ||||||||
| WBCnstr00017093 | |||||||||
| WBCnstr00017395 | |||||||||
| WBCnstr00018187 | |||||||||
| WBCnstr00037865 | |||||||||
| Construct_product (12) | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (84) | |||||||||
| Interaction (24) | |||||||||
| Map_info | Map | II | Position | 0.842334 | Error | 0.001708 | |||
| Positive | Positive_clone | C34C6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5162 | |||||||
| 5443 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (23) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
