tram-1 encodes the C. elegans ortholog of translocating chain-associated membrane protein 1; by homology, TRAM-1 is predicted to function in translocation of protein across the endoplasmic reticulum membrane; TRAM-1 localizes to the rough endoplasmic reticulum (ER) as well as to post-ER compartments such as the ciliary base.
Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation and protein insertion into ER membrane. Located in dendrite terminus; periciliary membrane compartment; and rough endoplasmic reticulum. Is an ortholog of human TRAM1 (translocation associated membrane protein 1); TRAM1L1 (translocation associated membrane protein 1 like 1); and TRAM2 (translocation associated membrane protein 2).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.