WormBase Tree Display for Gene: WBGene00007646

WBGene00007646 SMap: S_parent: Sequence: C17E4
  Identity: Version: 2
    Name: CGC_name: nkb-1 Person_evidence: WBPerson919
            WBPerson287
      Sequence_name: C17E4.9
      Molecular_name: C17E4.9a
        C17E4.9a.1
        CE08258
        C17E4.9b
      Other_name: CELE_C17E4.9 Accession_evidence: NDB BX284601
      Public_name: nkb-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:48 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 21 Oct 2008 09:57:22 WBPerson2970 Name_change: CGC_name: nkb-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nkb
    Allele (34)
    Strain: WBStrain00031814
    RNASeq_FPKM (74)
    GO_annotation (17)
    Contained_in_operon: CEOP1544
    Ortholog (59)
    Paralog: WBGene00010117 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00008074 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Automated_description: Predicted to enable ATPase activator activity. Predicted to be involved in intracellular monoatomic cation homeostasis and monoatomic cation transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of sodium:potassium-exchanging ATPase complex. Expressed in neurons and non-striated muscle. Human ortholog(s) of this gene implicated in several diseases, including atrophic gastritis; autoimmune gastritis; and essential hypertension. Is an ortholog of several human genes including ATP1B1 (ATPase Na+/K+ transporting subunit beta 1); ATP1B2 (ATPase Na+/K+ transporting subunit beta 2); and ATP1B3 (ATPase Na+/K+ transporting subunit beta 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:8929 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:820)
      DOID:10825 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:804)
      DOID:0040090 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:820)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:820)
  Molecular_info: Corresponding_CDS: C17E4.9a
    Corresponding_transcript: C17E4.9b
      C17E4.9a.1
    Other_sequence (23)
    Associated_feature: WBsf643584
      WBsf656741
      WBsf656742
      WBsf656743
      WBsf1010369
      WBsf218276
      WBsf218277
      WBsf218278
  Experimental_info: RNAi_result: WBRNAi00085451 Inferred_automatically: RNAi_primary
      WBRNAi00024582 Inferred_automatically: RNAi_primary
      WBRNAi00029006 Inferred_automatically: RNAi_primary
      WBRNAi00071041 Inferred_automatically: RNAi_primary
      WBRNAi00024583 Inferred_automatically: RNAi_primary
      WBRNAi00071686 Inferred_automatically: RNAi_primary
      WBRNAi00106126 Inferred_automatically: RNAi_primary
      WBRNAi00116734 Inferred_automatically: RNAi_primary
      WBRNAi00040802 Inferred_automatically: RNAi_primary
      WBRNAi00002975 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr8227
      Expr8229
      Expr11316
      Expr1017842
      Expr1033304
      Expr1144844
      Expr2014268
      Expr2032508
    Drives_construct: WBCnstr00018766
    Construct_product: WBCnstr00013193
      WBCnstr00013195
    Microarray_results (25)
    Expression_cluster: WBPaper00005700:transmembrane_protein
      WBPaper00028451:Low_abundance_spermatogenesis_enriched
      WBPaper00030922:glycosylated_protein
      WBPaper00032425:up_in_zfp-1
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00038213:E.coli(LF82)_72h_upregulated
      WBPaper00038289:oocyte_protein
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040965:lipid-droplet_associated_protein
      WBPaper00042477:prp-8(RNAi)_upregulated_RNAseq
      WBPaper00044034:LEC-1_associated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_downregulated_Day5
      WBPaper00044746:aging_downregulated_HeatShock
      WBPaper00045303:ZK1236.1(tm4178)_upregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045774:clk-1_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046509:htz-1(ok3099)_downregulated
      WBPaper00048910:mRNA-interacting_protein
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049626:UNC-75_target
      WBPaper00050182:lmn-1(L535P)_upregulated
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050599:nicotine(0.01mM)_upregulated
      WBPaper00050599:nicotine(1mM)_upregulated
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:body-wall-muscle_nucleus_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00052987:UV_upregulated_xpc-1;csb-1
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00055103:thoc-5(wy822)_upregulated
      WBPaper00055482:pmt-2(RNAi)_downregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056900:PID-3_interacting
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059174:MEG-3_interacting
      WBPaper00059328:mrps-5(RNAi)_upregulated_protein
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061377:MYRF-2_interacting
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:npp-8_4355-afd-1_4796
      WBPaper00061651:I3_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064201:SNA-3_interacting
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026980:intestine_enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00032165:differentially_expressed_with_age_medoid_4
      WBPaper00035905:FBF-1_Associated
      WBPaper00040210:Chlorpyrifos_24C_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045263:ProLongevity-mtROS_upregulated
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated
      [cgc6390]:mixed_oogenesis-somatic
    Interaction (25)
  Map_info: Map: I Position: 3.76304 Error: 0.00056
    Positive: Positive_clone: C17E4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00005423
    WBPaper00010788
    WBPaper00018962
    WBPaper00031996
    WBPaper00038491
    WBPaper00043657
    WBPaper00049828
    WBPaper00055090
    WBPaper00063976
    WBPaper00064339
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene