WormBase Tree Display for Gene: WBGene00007016
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| WBGene00007016 | Evidence | Author_evidence | Bourbon H-M | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | R12B2 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | mdt-15 | |||||||
| Sequence_name | R12B2.5 | ||||||||
| Molecular_name | R12B2.5a | ||||||||
| R12B2.5a.1 | |||||||||
| CE30108 | |||||||||
| R12B2.5b | |||||||||
| CE25078 | |||||||||
| R12B2.5a.2 | |||||||||
| R12B2.5a.3 | |||||||||
| R12B2.5b.1 | |||||||||
| R12B2.5b.2 | |||||||||
| Other_name | CELE_R12B2.5 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | mdt-15 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 14 May 2004 11:48:16 | WBPerson1845 | Event | Created | |||
| 2 | 02 Mar 2018 11:09:16 | WBPerson4025 | Event | Split_into | WBGene00303073 | ||||
| Split_into | WBGene00303073 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mdt | ||||||||
| Allele (89) | |||||||||
| Possibly_affected_by | WBVar02153194 | ||||||||
| Strain (12) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (33) | |||||||||
| Paralog | WBGene00008549 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00021901 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00017778 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00017929 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | mdt-15 encodes, by alternative splicing, two isoforms of a Mediator subunit orthologous to human MED15; together with NHR-49 and SBP-1, MDT-15 is required for normal fat accumulation, for expression of fatty acid (FA) desaturase genes (fat-5, fat-6, and fat-7), for normal levels of mono- and polyunsaturated FAs (PUFAs), and for viability, fecundity, mobility, and normally long lifespan; several of these phenotypes can be at least partially suppressed by supplying PUFAs in the food medium; in part through NHR-49, MDT-15 participates in basal and fasting-induced transcription of numerous other metabolic genes, such as gei-7 and acs-2; independently of NHR-49 and SBP-1, MDT-15 ensures appropriate transcriptional response and survival in response to toxins and heavy metals by inducing select detoxification genes encoding such as cdr-1, cyp-35C1, gst-5, mtl-1, mtl-2, ugt-1, ugt-8, and others; mdt-15 is expressed at constant levels from embryos to adulthood, in several head neurons and intestine; MDT-15 binds NHR-49 and NHR-64 in yeast two-hybrid assays, and SBP-1 in GST pull-down assays. | Paper_evidence | WBPaper00027365 | |||||
| WBPaper00027707 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 31 Jan 2008 00:00:00 | ||||||||
| Automated_description | Enables nuclear receptor binding activity and transcription coactivator activity. Involved in several processes, including determination of adult lifespan; nematode larval development; and sequestering of triglyceride. Predicted to be located in nucleus. Expressed in head. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in schizophrenia. Is an ortholog of human MED15 (mediator complex subunit 15). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0060413 | Homo sapiens | Paper_evidence | WBPaper00047004 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 20 Sep 2018 00:00:00 | ||||||||
| Potential_model | DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14248) | |||||
| Disease_relevance | 22q11.2 deletion syndrome (22q11.2DS) is the most common human deletion syndrome caused by deletion of a small piece of chromosome 22, characterized by neurodevelopmental defects, schizophrenia, congenital cardiac and craniofacial abnormalites (includes DiGeorge Syndrome and velocardiofacial syndrome); the 22q11.2 deletion overlaps several protein-coding genes including MED15 (mediator complex subunit 15); the C. elegans functional ortholog, mdt-15, is involved in fatty acid metabolism, the xenobiotic-induced expression of p38 MAP kinase PMK-1-dependent immune gene, and in oxidative stress responses; mutant phenotypes of mdt-15 include sterility, increased apoptosis, decreased protein expression, un-coordinated locomotion, and hypersensitivity to toxin exposure. | Homo sapiens | Paper_evidence | WBPaper00031850 | |||||
| WBPaper00045330 | |||||||||
| WBPaper00044077 | |||||||||
| WBPaper00027365 | |||||||||
| WBPaper00045290 | |||||||||
| Accession_evidence | OMIM | 611867 | |||||||
| 607372 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 21 Sep 2015 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000374 | ||||||||
| Molecular_info | Corresponding_CDS | R12B2.5a | |||||||
| R12B2.5b | |||||||||
| Corresponding_CDS_history | R12B2.5c:wp264 | ||||||||
| Corresponding_transcript | R12B2.5a.1 | ||||||||
| R12B2.5a.2 | |||||||||
| R12B2.5a.3 | |||||||||
| R12B2.5b.1 | |||||||||
| R12B2.5b.2 | |||||||||
| Other_sequence (43) | |||||||||
| Associated_feature | WBsf651077 | ||||||||
| WBsf666928 | |||||||||
| WBsf978980 | |||||||||
| Experimental_info | RNAi_result (85) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00001928 | ||||||||
| WBCnstr00002264 | |||||||||
| WBCnstr00004278 | |||||||||
| WBCnstr00004334 | |||||||||
| WBCnstr00034035 | |||||||||
| WBCnstr00042004 | |||||||||
| Construct_product | WBCnstr00034035 | ||||||||
| Regulate_expr_cluster | WBPaper00031850:mdt-15(RNAi)_downregulated | ||||||||
| WBPaper00031850:mdt-15(RNAi)_upregulated | |||||||||
| WBPaper00048952:glucose_induced | |||||||||
| WBPaper00048952:glucose_repressed | |||||||||
| WBPaper00056290:mdt-15(mg584)_downregulated | |||||||||
| WBPaper00056290:mdt-15(mg584)_upregulated | |||||||||
| WBPaper00057158:mdt-15(tm2182)_dependent_15C_downregulated | |||||||||
| WBPaper00057158:mdt-15(tm2182)_dependent_15C_upregulated | |||||||||
| WBPaper00065288:mdt-15(tm2182)_downregulated | |||||||||
| WBPaper00065288:mdt-15(tm2182)_upregulated | |||||||||
| Antibody | WBAntibody00001868 | ||||||||
| WBAntibody00002490 | |||||||||
| Microarray_results (35) | |||||||||
| Expression_cluster (103) | |||||||||
| Interaction (135) | |||||||||
| WBProcess | WBbiopr:00000121 | ||||||||
| Map_info | Map | III | Position | -1.43929 | Error | 0.000147 | |||
| Positive | Positive_clone | R12B2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5632 | |||||||
| Pseudo_map_position | |||||||||
| Reference (91) | |||||||||
| Picture | WBPicture0000013096 | ||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
