WormBase Tree Display for Gene: WBGene00006970

WBGene00006970 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: F28F9
  Identity: Version: 2
    Name: CGC_name: zag-1 Person_evidence: WBPerson110
      Sequence_name: F28F9.1
      Molecular_name: F28F9.1
        F28F9.1.1
        CE34546
      Other_name: zfh-1 Person_evidence: WBPerson1103
        CELE_F28F9.1 Accession_evidence: NDB BX284604
      Public_name: zag-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:44 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 30 Sep 2011 14:38:09 WBPerson2970 Name_change: Other_name: zfh-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: zag
    Allele (88)
    Strain (12)
    RNASeq_FPKM (74)
    GO_annotation (22)
    Ortholog (36)
    Paralog: WBGene00000462 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009553 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00018446 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: zag-1 encodes a homeodomain protein of the ZFH class which consists of a homeodomain flanked by two clusters of C2H2-type zinc fingers and is related to transcriptional repressors encoded by Drosophila zfh-1 and the vertebrate ZEB genes; ZAG-1 is required for locomotion, for neuronal differentiation, and for proper axonal branching and fasciculation; from late embryogenesis through adult stages of development, ZAG-1 is expressed dynamically in head and tail neurons and in the intestinal and anal depressor muscles. Paper_evidence: WBPaper00006104
            WBPaper00006106
          Curator_confirmed: WBPerson1843
          Date_last_updated: 14 Aug 2006 00:00:00
      Automated_description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; neuron differentiation; and regulation of cell differentiation. Located in nucleus. Expressed in body wall musculature; enteric muscle; neurons; pharynx; and somatic nervous system. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Mowat-Wilson syndrome; and corneal dystrophy (multiple). Is an ortholog of human ZEB1 (zinc finger E-box binding homeobox 1) and ZEB2 (zinc finger E-box binding homeobox 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0110857 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11642)
      DOID:11555 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11642)
      DOID:10487 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14881)
      DOID:0060485 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14881)
  Molecular_info: Corresponding_CDS: F28F9.1
    Corresponding_CDS_history: F28F9.1:wp88
      F28F9.1:wp102
    Corresponding_transcript: F28F9.1.1
    Other_sequence (23)
    Associated_feature (26)
    Gene_product_binds (9188)
    Transcription_factor: WBTranscriptionFactor000277
  Experimental_info: RNAi_result: WBRNAi00031537 Inferred_automatically: RNAi_primary
      WBRNAi00045855 Inferred_automatically: RNAi_primary
      WBRNAi00014064 Inferred_automatically: RNAi_primary
      WBRNAi00115808 Inferred_automatically: RNAi_primary
      WBRNAi00115917 Inferred_automatically: RNAi_primary
    Expr_pattern (20)
    Drives_construct (13)
    Construct_product: WBCnstr00005180
      WBCnstr00005181
      WBCnstr00016870
      WBCnstr00034063
    Microarray_results (19)
    Expression_cluster: WBPaper00029359_1166
      WBPaper00029359_1194
      WBPaper00029359_1197
      WBPaper00029359_1240
      WBPaper00029359_1243
      WBPaper00029359_1291
      WBPaper00029359_1336
      WBPaper00029359_1546
      WBPaper00029359_1549
      WBPaper00029359_1557
      WBPaper00029359_1599
      WBPaper00031040:Cluster_6
      WBPaper00035197:fer-1_downregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:A-class-motor-neurons_larva_enriched
      WBPaper00037950:A-class-motor-neurons_larva_SelectivelyEnriched
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00041222:hlh-1(cc561)_upregulated
      WBPaper00041222:unc-120(st364)_downregulated
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045316:prg-1_upregulated_L4
      WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00046338:body_muscle_unique
      WBPaper00046509:htz-1(ok3099)_downregulated
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_4
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051404:alg-2(ok304)_upregulated
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056167:Cry5B_upregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056586:kri-1(ok1251);mpk-2(ok219)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057068:numr-1(RNAi)_downregulated_Cadmium
      WBPaper00057149:prgn-1(tm985)_downregulated
      WBPaper00057347:nhr-14(tm1473)_downreglated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058711:skn-1(lax188)_upregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00058969:RIS_enriched
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059477:hlh-2(RNAi)_regulated
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059735:glucose_upregulated_lpin-1(RNAi)
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060273:isp-1(qm150)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:AIN_parent
      WBPaper00061340:ALA
      WBPaper00061340:ALM_BDU
      WBPaper00061340:ALM_PLM
      WBPaper00061340:ALN
      WBPaper00061340:AVG
      WBPaper00061340:AVH
      WBPaper00061340:AVH_parent
      WBPaper00061340:AVK
      WBPaper00061340:AVL
      WBPaper00061340:CAN
      WBPaper00061340:DA
      WBPaper00061340:DB
      WBPaper00061340:DD
      WBPaper00061340:DVC
      WBPaper00061340:DVC_parent
      WBPaper00061340:GLR
      WBPaper00061340:Intestinal_and_rectal_muscle
      WBPaper00061340:M1_parent
      WBPaper00061340:M4_parent
      WBPaper00061340:mu_int_mu_anal
      WBPaper00061340:Neuroblast_ALA_RMED
      WBPaper00061340:Neuroblast_ALM_BDU
      WBPaper00061340:Neuroblast_AVG_RIR
      WBPaper00061340:Neuroblast_PVC_LUA
      WBPaper00061340:PLM
      WBPaper00061340:PLM_ALN_grandparent
      WBPaper00061340:PVQ_parent
      WBPaper00061340:PVR
      WBPaper00061340:RIA_parent
      WBPaper00061340:RIC_parent
      WBPaper00061340:RID
      WBPaper00061340:RID_parent
      WBPaper00061340:RIH
      WBPaper00061340:RIM_parent
      WBPaper00061340:RIV
      WBPaper00061340:SIA
      WBPaper00061340:SMB
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:sol-1-jnk-1_18695
      WBPaper00061651:DB_enriched
      WBPaper00061651:PDA_enriched
      WBPaper00061651:PLN_enriched
      WBPaper00061651:SMB_enriched
      WBPaper00061651:VA12_enriched
      WBPaper00061753:csr-1(tor159)_downregulated_20C
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062184:PA14_downregulated
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00065029:cadmium_upregulated
      WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal
      WBPaper00065560:E.coli-HB101_downregulated_F3
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065841:1_2
      WBPaper00065841:6_0
      WBPaper00065841:6_1
      WBPaper00065841:6_3
      WBPaper00065841:14_2
      WBPaper00065841:23_0
      WBPaper00065841:28_0
      WBPaper00065841:29_0
      WBPaper00065841:31_0
      WBPaper00065841:51_0
      WBPaper00065841:51_1
      WBPaper00065841:68_1
      WBPaper00065841:74_0
      WBPaper00065841:96_0
      WBPaper00065841:105_0
      WBPaper00065841:108_0
      WBPaper00065841:115_0
      WBPaper00065841:129_0
      WBPaper00065841:132_0
      WBPaper00065841:133_0
      WBPaper00065841:134_0
      WBPaper00065841:136_0
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066093:E.coli-purE_downregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066232:ash-2(RNAi)_upregulated_WT
      WBPaper00066232:hsf-1(RNAi)_downregulated_ash-2
      cgc4386_cluster_6_6
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00035227:heat_shock_regulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00042548:miRISC_enriched
      WBPaper00045673:colistin_upregulated
    Interaction (92)
    Product_binds_matrix (3)
  Map_info: Map: IV Position: -2.06697 Error: 0.013802
    Positive: Positive_clone: F28F9 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (30)
  Remark: Sequence connection from [Clark SG]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene