WormBase Tree Display for Gene: WBGene00006948

WBGene00006948 SMap: S_parent: Sequence: F52E4
  Identity: Version: 1
    Name: CGC_name: wrt-2 Person_evidence: WBPerson83
      Sequence_name: F52E4.6
      Molecular_name: F52E4.6
        F52E4.6.1
        CE07273
      Other_name: CELE_F52E4.6 Accession_evidence: NDB BX284606
      Public_name: wrt-2
    DB_info: Database: AceView gene XD712
        WormQTL gene WBGene00006948
        WormFlux gene WBGene00006948
        NDB locus_tag CELE_F52E4.6
        Panther gene CAEEL|WormBase=WBGene00006948|UniProtKB=Q20677
          family PTHR46706
        NCBI gene 180597
        RefSeq protein NM_076128.7
        TREEFAM TREEFAM_ID TF316084
        TrEMBL UniProtAcc Q20677
        UniProt_GCRP UniProtAcc Q20677
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: wrt
    Allele (28)
    Strain: WBStrain00007244
      WBStrain00007245
      WBStrain00007246
      WBStrain00007914
      WBStrain00032807
    RNASeq_FPKM (74)
    Ortholog (23)
    Paralog (24)
    Structured_description: Concise_description: wrt-2 encodes a hedgehog-like protein, with an N-terminal signalsequence, a Wart domain, and a C-terminal region of low-complexitysequence; WRT-2 is expressed in seam cells and hypodermal syncytia; theWart domain is predicted to form a cysteine-crosslinked protein involvedin intercellular signalling, and it has subtle similarity to theN-terminal Hedge domain of HEDGEHOG proteins; WRT-2 is weakly requiredfor normal molting; WRT-2 is also required for normal growth to fullsize and locomotion; all of these requirements may reflect commondefects in cholesterol-dependent hedgehog-like signalling or in vesicletrafficking; in two-hybrid assays, WRT-2 binds EYA-1, which may parallelthe derepression of Drosophila eyes absent by HEDGEHOG. Paper_evidence: WBPaper00003717
            WBPaper00006332
            WBPaper00026841
            WBPaper00027263
            WBPaper00027697
          Curator_confirmed: WBPerson567
          Date_last_updated: 05 Nov 2006 00:00:00
      Automated_description: Expressed in hypodermal cell and hypodermis. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F52E4.6
    Corresponding_transcript: F52E4.6.1
    Other_sequence (41)
    Associated_feature: WBsf653804
      WBsf653805
      WBsf1022564
      WBsf1022565
      WBsf1022566
      WBsf237135
      WBsf237136
  Experimental_info: RNAi_result: WBRNAi00077008 Inferred_automatically: RNAi_primary
      WBRNAi00047999 Inferred_automatically: RNAi_primary
      WBRNAi00076981 Inferred_automatically: RNAi_primary
      WBRNAi00015424 Inferred_automatically: RNAi_primary
      WBRNAi00032625 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr642
      Expr13913
      Expr1027232
      Expr1032962
      Expr1151814
      Expr2018077
      Expr2036215
    Drives_construct (22)
    Construct_product: WBCnstr00034080
    Microarray_results (18)
    Expression_cluster (251)
    Interaction (101)
    WBProcess: WBbiopr:00000123
  Map_info: Map: X Position: -12.232 Error: 0.019344
    Positive: Positive_clone: F52E4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (13)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene