WormBase Tree Display for Gene: WBGene00006844
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| WBGene00006844 | Evidence | Paper_evidence | WBPaper00014402 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | D1081 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-120 | Person_evidence | WBPerson261 | |||||
| Sequence_name | D1081.2 | ||||||||
| Molecular_name | D1081.2 | ||||||||
| D1081.2.1 | |||||||||
| CE05534 | |||||||||
| Other_name | CELE_D1081.2 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | unc-120 | ||||||||
| DB_info | Database | AceView | gene | 1J37 | |||||
| WormQTL | gene | WBGene00006844 | |||||||
| WormFlux | gene | WBGene00006844 | |||||||
| NDB | locus_tag | CELE_D1081.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006844|UniProtKB=Q18955 | |||||||
| family | PTHR48019 | ||||||||
| NCBI | gene | 172636 | |||||||
| RefSeq | protein | NM_059895.5 | |||||||
| SwissProt | UniProtAcc | Q18955 | |||||||
| TREEFAM | TREEFAM_ID | TF318482 | |||||||
| UniProt_GCRP | UniProtAcc | Q18955 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00248740 | ||||||||
| Allele (49) | |||||||||
| Legacy_information | [C.elegansII] st364ts : progressive paralysis at 20C; mature adults very sluggish at 15C; number of thick and thin filaments variably reduced. Sterile at 25C. [RW] | ||||||||
| Strain | WBStrain00033494 | ||||||||
| WBStrain00033502 | |||||||||
| WBStrain00036753 | |||||||||
| WBStrain00029983 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (37) | |||||||||
| Paralog | WBGene00003182 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | unc-120 encodes a member of the MADS-box family of transcription factors that is most closely related to Drosophila blistered and the vertebrate serum response factors (SRFs); UNC-120 is required for locomotion and muscle development and for formation of the normal number of muscle A and I bands; UNC-120 is also required for maintaining wild-type expression levels of the muscle components actin and myosin; UNC-120 is first expressed in the early embryo in body wall muscle precursors and later is expressed in both body wall and vulval muscles. | Paper_evidence | WBPaper00002665 | |||||
| WBPaper00004244 | |||||||||
| WBPaper00014402 | |||||||||
| WBPaper00023618 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 05 Jul 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within positive regulation of muscle cell differentiation. Located in nucleus. Expressed in non-striated muscle and pharyngeal cell. Human ortholog(s) of this gene implicated in cardiomyopathy; congestive heart failure; and lymphangioleiomyomatosis. Is an ortholog of human SRF (serum response factor). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:6000 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11291) | ||||
| DOID:3319 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11291) | ||||||
| DOID:0050700 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11291) | ||||||
| Molecular_info | Corresponding_CDS | D1081.2 | |||||||
| Corresponding_transcript | D1081.2.1 | ||||||||
| Other_sequence (17) | |||||||||
| Associated_feature (14) | |||||||||
| Transcription_factor | WBTranscriptionFactor000221 | ||||||||
| Experimental_info | RNAi_result (63) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00002859 | ||||||||
| WBCnstr00005844 | |||||||||
| WBCnstr00005990 | |||||||||
| WBCnstr00012539 | |||||||||
| WBCnstr00016136 | |||||||||
| WBCnstr00016137 | |||||||||
| WBCnstr00021272 | |||||||||
| WBCnstr00034125 | |||||||||
| Construct_product | WBCnstr00016543 | ||||||||
| WBCnstr00034125 | |||||||||
| WBCnstr00038802 | |||||||||
| Regulate_expr_cluster | WBPaper00041222:unc-120(st364)_downregulated | ||||||||
| WBPaper00041222:unc-120(st364)_upregulated | |||||||||
| WBPaper00060634:unc-120(st364)_downregulated | |||||||||
| WBPaper00060634:unc-120(st364)_upregulated | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (163) | |||||||||
| Interaction | WBInteraction000006262 | ||||||||
| WBInteraction000006288 | |||||||||
| WBInteraction000006307 | |||||||||
| WBInteraction000006335 | |||||||||
| WBInteraction000006376 | |||||||||
| WBInteraction000007718 | |||||||||
| WBInteraction000007720 | |||||||||
| WBInteraction000007724 | |||||||||
| WBInteraction000028903 | |||||||||
| WBInteraction000029350 | |||||||||
| WBInteraction000029374 | |||||||||
| WBInteraction000029378 | |||||||||
| WBInteraction000032534 | |||||||||
| WBInteraction000032555 | |||||||||
| WBInteraction000032727 | |||||||||
| WBInteraction000032756 | |||||||||
| WBInteraction000032868 | |||||||||
| WBInteraction000032980 | |||||||||
| WBInteraction000032981 | |||||||||
| WBInteraction000033180 | |||||||||
| WBInteraction000033762 | |||||||||
| WBInteraction000034768 | |||||||||
| WBInteraction000036732 | |||||||||
| WBInteraction000037139 | |||||||||
| WBInteraction000037140 | |||||||||
| WBInteraction000037141 | |||||||||
| WBInteraction000040386 | |||||||||
| WBInteraction000043564 | |||||||||
| WBInteraction000045199 | |||||||||
| WBInteraction000045372 | |||||||||
| WBInteraction000046517 | |||||||||
| WBInteraction000047994 | |||||||||
| WBInteraction000049594 | |||||||||
| WBInteraction000050448 | |||||||||
| WBInteraction000052302 | |||||||||
| WBInteraction000052342 | |||||||||
| WBInteraction000052343 | |||||||||
| WBInteraction000052680 | |||||||||
| WBInteraction000052681 | |||||||||
| WBInteraction000052824 | |||||||||
| WBInteraction000110168 | |||||||||
| WBInteraction000135239 | |||||||||
| WBInteraction000146783 | |||||||||
| WBInteraction000146784 | |||||||||
| WBInteraction000208874 | |||||||||
| WBInteraction000210883 | |||||||||
| WBInteraction000231293 | |||||||||
| WBInteraction000311203 | |||||||||
| WBInteraction000340924 | |||||||||
| WBInteraction000350797 | |||||||||
| WBInteraction000372939 | |||||||||
| WBInteraction000377343 | |||||||||
| WBInteraction000389055 | |||||||||
| WBInteraction000463484 | |||||||||
| WBInteraction000500744 | |||||||||
| WBInteraction000500745 | |||||||||
| WBInteraction000500746 | |||||||||
| WBInteraction000500747 | |||||||||
| WBInteraction000500751 | |||||||||
| WBInteraction000503491 | |||||||||
| WBInteraction000503493 | |||||||||
| WBInteraction000503495 | |||||||||
| WBInteraction000503991 | |||||||||
| WBInteraction000544755 | |||||||||
| WBInteraction000575491 | |||||||||
| Map_info | Map | I | Position | 2.83481 | Error | 0.009013 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C48B1 | |||||||
| D1081 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point | 3686 | |||||||
| 6118 | |||||||||
| Multi_point | 1386 | ||||||||
| 1825 | |||||||||
| 1826 | |||||||||
| 1827 | |||||||||
| 1828 | |||||||||
| 2288 | |||||||||
| 4684 | |||||||||
| Reference (34) | |||||||||
| Method | Gene |
