Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00006844

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00006844EvidencePaper_evidenceWBPaper00014402
SMapS_parentSequenceD1081
IdentityVersion1
NameCGC_nameunc-120Person_evidenceWBPerson261
Sequence_nameD1081.2
Molecular_nameD1081.2
D1081.2.1
CE05534
Other_nameCELE_D1081.2Accession_evidenceNDBBX284601
Public_nameunc-120
DB_infoDatabaseAceViewgene1J37
WormQTLgeneWBGene00006844
WormFluxgeneWBGene00006844
NDBlocus_tagCELE_D1081.2
PanthergeneCAEEL|WormBase=WBGene00006844|UniProtKB=Q18955
familyPTHR48019
NCBIgene172636
RefSeqproteinNM_059895.5
SwissProtUniProtAccQ18955
TREEFAMTREEFAM_IDTF318482
UniProt_GCRPUniProtAccQ18955
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:43WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Reference_alleleWBVar00248740
Allele (49)
Legacy_information[C.elegansII] st364ts : progressive paralysis at 20C; mature adults very sluggish at 15C; number of thick and thin filaments variably reduced. Sterile at 25C. [RW]
StrainWBStrain00033494
WBStrain00033502
WBStrain00036753
WBStrain00029983
RNASeq_FPKM (74)
GO_annotation (15)
Ortholog (37)
ParalogWBGene00003182Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionunc-120 encodes a member of the MADS-box family of transcription factors that is most closely related to Drosophila blistered and the vertebrate serum response factors (SRFs); UNC-120 is required for locomotion and muscle development and for formation of the normal number of muscle A and I bands; UNC-120 is also required for maintaining wild-type expression levels of the muscle components actin and myosin; UNC-120 is first expressed in the early embryo in body wall muscle precursors and later is expressed in both body wall and vulval muscles.Paper_evidenceWBPaper00002665
WBPaper00004244
WBPaper00014402
WBPaper00023618
Curator_confirmedWBPerson1843
Date_last_updated05 Jul 2006 00:00:00
Automated_descriptionPredicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within positive regulation of muscle cell differentiation. Located in nucleus. Expressed in non-striated muscle and pharyngeal cell. Human ortholog(s) of this gene implicated in cardiomyopathy; congestive heart failure; and lymphangioleiomyomatosis. Is an ortholog of human SRF (serum response factor).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:6000Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11291)
DOID:3319Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11291)
DOID:0050700Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11291)
Molecular_infoCorresponding_CDSD1081.2
Corresponding_transcriptD1081.2.1
Other_sequence (17)
Associated_feature (14)
Transcription_factorWBTranscriptionFactor000221
Experimental_infoRNAi_resultWBRNAi00086380Inferred_automaticallyRNAi_primary
WBRNAi00069673Inferred_automaticallyRNAi_primary
WBRNAi00069659Inferred_automaticallyRNAi_primary
WBRNAi00003270Inferred_automaticallyRNAi_primary
WBRNAi00086381Inferred_automaticallyRNAi_primary
WBRNAi00090437Inferred_automaticallyRNAi_primary
WBRNAi00086367Inferred_automaticallyRNAi_primary
WBRNAi00086368Inferred_automaticallyRNAi_primary
WBRNAi00068559Inferred_automaticallyRNAi_primary
WBRNAi00030359Inferred_automaticallyRNAi_primary
WBRNAi00086373Inferred_automaticallyRNAi_primary
WBRNAi00086369Inferred_automaticallyRNAi_primary
WBRNAi00090531Inferred_automaticallyRNAi_primary
WBRNAi00089797Inferred_automaticallyRNAi_primary
WBRNAi00077300Inferred_automaticallyRNAi_primary
WBRNAi00068557Inferred_automaticallyRNAi_primary
WBRNAi00090291Inferred_automaticallyRNAi_primary
WBRNAi00072397Inferred_automaticallyRNAi_primary
WBRNAi00069667Inferred_automaticallyRNAi_primary
WBRNAi00074059Inferred_automaticallyRNAi_primary
WBRNAi00024939Inferred_automaticallyRNAi_primary
WBRNAi00091311Inferred_automaticallyRNAi_primary
WBRNAi00068558Inferred_automaticallyRNAi_primary
WBRNAi00074060Inferred_automaticallyRNAi_primary
WBRNAi00085023Inferred_automaticallyRNAi_primary
WBRNAi00043410Inferred_automaticallyRNAi_primary
WBRNAi00069660Inferred_automaticallyRNAi_primary
WBRNAi00068987Inferred_automaticallyRNAi_primary
WBRNAi00072395Inferred_automaticallyRNAi_primary
WBRNAi00068561Inferred_automaticallyRNAi_primary
WBRNAi00090036Inferred_automaticallyRNAi_primary
WBRNAi00069661Inferred_automaticallyRNAi_primary
WBRNAi00069665Inferred_automaticallyRNAi_primary
WBRNAi00074054Inferred_automaticallyRNAi_primary
WBRNAi00086382Inferred_automaticallyRNAi_primary
WBRNAi00069662Inferred_automaticallyRNAi_primary
WBRNAi00069668Inferred_automaticallyRNAi_primary
WBRNAi00090390Inferred_automaticallyRNAi_primary
WBRNAi00069674Inferred_automaticallyRNAi_primary
WBRNAi00024940Inferred_automaticallyRNAi_primary
WBRNAi00086372Inferred_automaticallyRNAi_primary
WBRNAi00069671Inferred_automaticallyRNAi_primary
WBRNAi00069664Inferred_automaticallyRNAi_primary
WBRNAi00064780Inferred_automaticallyRNAi_primary
WBRNAi00064808Inferred_automaticallyRNAi_primary
WBRNAi00074057Inferred_automaticallyRNAi_primary
WBRNAi00074056Inferred_automaticallyRNAi_primary
WBRNAi00089973Inferred_automaticallyRNAi_primary
WBRNAi00072396Inferred_automaticallyRNAi_primary
WBRNAi00068560Inferred_automaticallyRNAi_primary
WBRNAi00069672Inferred_automaticallyRNAi_primary
WBRNAi00077313Inferred_automaticallyRNAi_primary
WBRNAi00064761Inferred_automaticallyRNAi_primary
WBRNAi00069663Inferred_automaticallyRNAi_primary
WBRNAi00086371Inferred_automaticallyRNAi_primary
WBRNAi00074058Inferred_automaticallyRNAi_primary
WBRNAi00069669Inferred_automaticallyRNAi_primary
WBRNAi00074055Inferred_automaticallyRNAi_primary
WBRNAi00064735Inferred_automaticallyRNAi_primary
WBRNAi00090484Inferred_automaticallyRNAi_primary
WBRNAi00069670Inferred_automaticallyRNAi_primary
WBRNAi00064849Inferred_automaticallyRNAi_primary
WBRNAi00069666Inferred_automaticallyRNAi_primary
Expr_pattern (11)
Drives_constructWBCnstr00002859
WBCnstr00005844
WBCnstr00005990
WBCnstr00012539
WBCnstr00016136
WBCnstr00016137
WBCnstr00021272
WBCnstr00034125
Construct_productWBCnstr00016543
WBCnstr00034125
WBCnstr00038802
Regulate_expr_clusterWBPaper00041222:unc-120(st364)_downregulated
WBPaper00041222:unc-120(st364)_upregulated
WBPaper00060634:unc-120(st364)_downregulated
WBPaper00060634:unc-120(st364)_upregulated
Microarray_results (20)
Expression_cluster (163)
Interaction (65)
Map_infoMapIPosition2.83481Error0.009013
Well_ordered
PositivePositive_cloneC48B1
D1081Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point3686
6118
Multi_point1386
1825
1826
1827
1828
2288
4684
Reference (34)
MethodGene