WormBase Tree Display for Gene: WBGene00006844
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WBGene00006844 | Evidence | Paper_evidence | WBPaper00014402 | ||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | D1081 | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | unc-120 | Person_evidence | WBPerson261 | |||||
Sequence_name | D1081.2 | ||||||||
Molecular_name | D1081.2 | ||||||||
D1081.2.1 | |||||||||
CE05534 | |||||||||
Other_name | CELE_D1081.2 | Accession_evidence | NDB | BX284601 | |||||
Public_name | unc-120 | ||||||||
DB_info | Database | AceView | gene | 1J37 | |||||
WormQTL | gene | WBGene00006844 | |||||||
WormFlux | gene | WBGene00006844 | |||||||
NDB | locus_tag | CELE_D1081.2 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00006844|UniProtKB=Q18955 | |||||||
family | PTHR48019 | ||||||||
NCBI | gene | 172636 | |||||||
RefSeq | protein | NM_059895.5 | |||||||
SwissProt | UniProtAcc | Q18955 | |||||||
TREEFAM | TREEFAM_ID | TF318482 | |||||||
UniProt_GCRP | UniProtAcc | Q18955 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | unc | ||||||||
Reference_allele | WBVar00248740 | ||||||||
Allele (49) | |||||||||
Legacy_information | [C.elegansII] st364ts : progressive paralysis at 20C; mature adults very sluggish at 15C; number of thick and thin filaments variably reduced. Sterile at 25C. [RW] | ||||||||
Strain | WBStrain00033494 | ||||||||
WBStrain00033502 | |||||||||
WBStrain00036753 | |||||||||
WBStrain00029983 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (15) | |||||||||
Ortholog (37) | |||||||||
Paralog | WBGene00003182 | Caenorhabditis elegans | From_analysis | Panther | |||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | unc-120 encodes a member of the MADS-box family of transcription factors that is most closely related to Drosophila blistered and the vertebrate serum response factors (SRFs); UNC-120 is required for locomotion and muscle development and for formation of the normal number of muscle A and I bands; UNC-120 is also required for maintaining wild-type expression levels of the muscle components actin and myosin; UNC-120 is first expressed in the early embryo in body wall muscle precursors and later is expressed in both body wall and vulval muscles. | Paper_evidence | WBPaper00002665 | |||||
WBPaper00004244 | |||||||||
WBPaper00014402 | |||||||||
WBPaper00023618 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 05 Jul 2006 00:00:00 | ||||||||
Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within positive regulation of muscle cell differentiation. Located in nucleus. Expressed in non-striated muscle and pharyngeal cell. Human ortholog(s) of this gene implicated in cardiomyopathy; congestive heart failure; and lymphangioleiomyomatosis. Is an ortholog of human SRF (serum response factor). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:6000 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11291) | ||||
DOID:3319 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11291) | ||||||
DOID:0050700 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11291) | ||||||
Molecular_info | Corresponding_CDS | D1081.2 | |||||||
Corresponding_transcript | D1081.2.1 | ||||||||
Other_sequence (17) | |||||||||
Associated_feature (14) | |||||||||
Transcription_factor | WBTranscriptionFactor000221 | ||||||||
Experimental_info | RNAi_result (63) | ||||||||
Expr_pattern (11) | |||||||||
Drives_construct | WBCnstr00002859 | ||||||||
WBCnstr00005844 | |||||||||
WBCnstr00005990 | |||||||||
WBCnstr00012539 | |||||||||
WBCnstr00016136 | |||||||||
WBCnstr00016137 | |||||||||
WBCnstr00021272 | |||||||||
WBCnstr00034125 | |||||||||
Construct_product | WBCnstr00016543 | ||||||||
WBCnstr00034125 | |||||||||
WBCnstr00038802 | |||||||||
Regulate_expr_cluster | WBPaper00041222:unc-120(st364)_downregulated | ||||||||
WBPaper00041222:unc-120(st364)_upregulated | |||||||||
WBPaper00060634:unc-120(st364)_downregulated | |||||||||
WBPaper00060634:unc-120(st364)_upregulated | |||||||||
Microarray_results (20) | |||||||||
Expression_cluster (163) | |||||||||
Interaction (65) | |||||||||
Map_info | Map | I | Position | 2.83481 | Error | 0.009013 | |||
Well_ordered | |||||||||
Positive | Positive_clone | C48B1 | |||||||
D1081 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
Mapping_data | 2_point | 3686 | |||||||
6118 | |||||||||
Multi_point | 1386 | ||||||||
1825 | |||||||||
1826 | |||||||||
1827 | |||||||||
1828 | |||||||||
2288 | |||||||||
4684 | |||||||||
Reference (34) | |||||||||
Method | Gene |