WormBase Tree Display for Gene: WBGene00006833
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| WBGene00006833 | SMap | S_parent | Sequence | F53F10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | unc-108 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F53F10.4 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | rab-2 | ||||||||
| unc-67 | Person_evidence | WBPerson261 | |||||||
| CELE_F53F10.4 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | unc-108 | ||||||||
| DB_info | Database | AceView | gene | 1E393 | |||||
| WormQTL | gene | WBGene00006833 | |||||||
| WormFlux | gene | WBGene00006833 | |||||||
| NDB | locus_tag | CELE_F53F10.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006833|UniProtKB=A0A2C9C2Y0 | |||||||
| family | PTHR47979 | ||||||||
| NCBI | gene | 171956 | |||||||
| RefSeq | protein | NM_001356805.3 | |||||||
| NM_001393282.1 | |||||||||
| NM_001356804.3 | |||||||||
| NM_001356806.3 | |||||||||
| TrEMBL | UniProtAcc | A0A2C9C2Y0 | |||||||
| A0A2C9C3C9 | |||||||||
| O01577 | |||||||||
| A0A2C9C379 | |||||||||
| UniProt_GCRP | UniProtAcc | A0A2C9C2Y0 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 18 Nov 2008 14:39:11 | WBPerson2970 | Event | Acquires_merge | WBGene00006800 | ||||
| Name_change | Other_name | unc-67 | |||||||
| Acquires_merge | WBGene00006800 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00089559 | ||||||||
| Allele (58) | |||||||||
| Legacy_information | n501dm : sluggish poor backing. Similar phenotype in n501/+. ES3. NA1. Possibly haplo-insufficient locus. | ||||||||
| See also n501, n777 | |||||||||
| [C.elegansII] n501dm : sluggish, poor backing. Similar phenotype in n501/+. ES3. OA1: n777. Possibly haplo-insufficient locus. [Park and Horvitz 1986a] | |||||||||
| e713 : sluggish can move well both forward and backward but frequently pauses or jams up. ES2 ME2. NA1. | |||||||||
| [C.elegansII] e713 : sluggish, can move well both forward and backward but frequently pauses or jams up. ES2 ME2. NA1. [Brenner 1974; MQ] | |||||||||
| Strain | WBStrain00023643 | ||||||||
| WBStrain00026794 | |||||||||
| WBStrain00026882 | |||||||||
| WBStrain00036101 | |||||||||
| WBStrain00040847 | |||||||||
| WBStrain00004200 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (38) | |||||||||
| Contained_in_operon | CEOP1116 | ||||||||
| Ortholog (37) | |||||||||
| Paralog (32) | |||||||||
| Structured_description | Concise_description | unc-108 encodes a small GTPase homologous to the Rab GTPases that function in endocytosis, membrane fusion, and vesicular trafficking events; unc-108 function is required in neurons for normal locomotion; unc-108 also functions in the removal of apoptotic cells, specifically it functions in engulfing cells for the recruitment and fusion of the lysosome to the phagosome; unc-108 is expressed in neurons and in engulfing cells. | Paper_evidence | WBPaper00015788 | |||||
| WBPaper00031470 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 14 Aug 2008 00:00:00 | ||||||||
| Automated_description | Enables GTPase activity. Involved in several processes, including dense core granule maturation; phagosome maturation involved in apoptotic cell clearance; and regulation of locomotion involved in locomotory behavior. Located in axon; cytoplasm; and neuronal cell body. Expressed in several structures, including excretory gland cell; hermaphrodite somatic gonadal cell; neurons; pharyngeal gland cell; and rectal gland cell. Is an ortholog of human RAB2A (RAB2A, member RAS oncogene family). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F53F10.4a | |||||||
| F53F10.4b | |||||||||
| F53F10.4c | |||||||||
| F53F10.4d | |||||||||
| Corresponding_transcript | F53F10.4a.1 | ||||||||
| F53F10.4b.1 | |||||||||
| F53F10.4c.1 | |||||||||
| F53F10.4d.1 | |||||||||
| Other_sequence (24) | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result (40) | ||||||||
| Expr_pattern (16) | |||||||||
| Drives_construct | WBCnstr00002664 | ||||||||
| WBCnstr00005792 | |||||||||
| WBCnstr00005793 | |||||||||
| WBCnstr00013020 | |||||||||
| WBCnstr00013022 | |||||||||
| WBCnstr00013277 | |||||||||
| WBCnstr00013541 | |||||||||
| WBCnstr00019190 | |||||||||
| WBCnstr00034128 | |||||||||
| Construct_product (21) | |||||||||
| Antibody | WBAntibody00001993 | ||||||||
| WBAntibody00001994 | |||||||||
| Microarray_results (28) | |||||||||
| Expression_cluster (143) | |||||||||
| Interaction (51) | |||||||||
| WBProcess | WBbiopr:00000013 | ||||||||
| WBbiopr:00000015 | |||||||||
| Map_info | Map | I | Position | -2.00793 | Error | 0.05662 | |||
| Positive | Positive_clone | F53F10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| From CDS info | |||||||||
| Mapping_data | 2_point | 59 | |||||||
| 80 | |||||||||
| 489 | |||||||||
| 490 | |||||||||
| Multi_point | 1290 | ||||||||
| 1291 | |||||||||
| 4973 | |||||||||
| 5623 | |||||||||
| 380 | |||||||||
| 381 | |||||||||
| 1288 | |||||||||
| Pos_neg_data | 363 | ||||||||
| Reference (55) | |||||||||
| Method | Gene |
