WormBase Tree Display for Gene: WBGene00006826
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| WBGene00006826 | SMap | S_parent | Sequence | F14D12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-97 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F14D12.2 | ||||||||
| Molecular_name | F14D12.2 | ||||||||
| F14D12.2.1 | |||||||||
| CE04392 | |||||||||
| Other_name | CELE_F14D12.2 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | unc-97 | ||||||||
| DB_info | Database | AceView | gene | XG213 | |||||
| WormQTL | gene | WBGene00006826 | |||||||
| WormFlux | gene | WBGene00006826 | |||||||
| NDB | locus_tag | CELE_F14D12.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006826|UniProtKB=P50464 | |||||||
| family | PTHR24210 | ||||||||
| NCBI | gene | 180827 | |||||||
| RefSeq | protein | NM_076542.8 | |||||||
| SwissProt | UniProtAcc | P50464 | |||||||
| UniProt_GCRP | UniProtAcc | P50464 | |||||||
| OMIM | gene | 607908 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00248846 | ||||||||
| Allele (24) | |||||||||
| Legacy_information | su110 : limp paralysed adults larvae paralysed slightly curled Egl; variable abnormal muscle birefringence; small easily disrupted sarcomeres. ES3 ME0. NA1. | ||||||||
| Strain | WBStrain00029279 | ||||||||
| WBStrain00037184 | |||||||||
| WBStrain00006435 | |||||||||
| WBStrain00008389 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (31) | |||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00004030 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | The unc-97 gene encodes a LIM domain-containing protein of the PINCH family that is highly similar to human LIMS1 (OMIM:602567) and LIMS2; UNC-97 functions as an adaptor protein important for assembly of muscle adherens junctions and the mechanosensory functions of the touch neurons; UNC-97 interacts with PAT-4/integrin-linked kinase and with UNC-98; UNC-97 colocalizes with PAT-3/beta integrin at dense bodies, focal adhesion-like muscle attachment structures. | Paper_evidence | WBPaper00003361 | |||||
| WBPaper00005261 | |||||||||
| WBPaper00005938 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables myosin binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of sarcomere organization; and sensory perception of mechanical stimulus. Located in several cellular components, including adherens junction; basal plasma membrane; and contractile fiber. Expressed in body wall musculature and vulval muscle. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2W. Is an ortholog of human LIMS1 (LIM zinc finger domain containing 1) and LIMS2 (LIM zinc finger domain containing 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110288 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16084) | ||||
| Molecular_info | Corresponding_CDS | F14D12.2 | |||||||
| Corresponding_transcript | F14D12.2.1 | ||||||||
| Other_sequence (52) | |||||||||
| Associated_feature (13) | |||||||||
| Transcription_factor | WBTranscriptionFactor000702 | ||||||||
| Experimental_info | RNAi_result (38) | ||||||||
| Expr_pattern | Chronogram707 | ||||||||
| Expr734 | |||||||||
| Expr5755 | |||||||||
| Expr8543 | |||||||||
| Expr14518 | |||||||||
| Expr1021966 | |||||||||
| Expr1032890 | |||||||||
| Expr1148541 | |||||||||
| Expr2017923 | |||||||||
| Expr2036059 | |||||||||
| Drives_construct | WBCnstr00000965 | ||||||||
| WBCnstr00000966 | |||||||||
| WBCnstr00002440 | |||||||||
| WBCnstr00012543 | |||||||||
| WBCnstr00013357 | |||||||||
| WBCnstr00019333 | |||||||||
| WBCnstr00034133 | |||||||||
| WBCnstr00041070 | |||||||||
| Construct_product | WBCnstr00000965 | ||||||||
| WBCnstr00012543 | |||||||||
| WBCnstr00013357 | |||||||||
| WBCnstr00016120 | |||||||||
| WBCnstr00016121 | |||||||||
| WBCnstr00019333 | |||||||||
| WBCnstr00034133 | |||||||||
| WBCnstr00041070 | |||||||||
| Antibody | WBAntibody00001194 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (153) | |||||||||
| Interaction (55) | |||||||||
| Anatomy_function | WBbtf0611 | ||||||||
| WBProcess | WBbiopr:00000006 | ||||||||
| Map_info | Map | X | Position | -4.48479 | Error | 0.052884 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F14D12 | Person_evidence | WBPerson260 | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Negative | Outside_rearr | mcDf2 | |||||||
| Mapping_data | 2_point | 396 | |||||||
| 397 | |||||||||
| Multi_point | 1207 | ||||||||
| 5465 | |||||||||
| Pos_neg_data | 10697 | ||||||||
| Landmark_gene | |||||||||
| Reference (51) | |||||||||
| Remark | [Hobert O] This gene has 5 LIM domains and no homeobox domain, information in F14D12.2 is incorrect. Remark added by sdm 4/98. | ||||||||
| Method | Gene |
