WormBase Tree Display for Gene: WBGene00006826
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WBGene00006826 | SMap | S_parent | Sequence | F14D12 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | unc | ||||||
Reference_allele | WBVar00248846 | ||||||
Allele (24) | |||||||
Legacy_information | su110 : limp paralysed adults larvae paralysed slightly curled Egl; variable abnormal muscle birefringence; small easily disrupted sarcomeres. ES3 ME0. NA1. | ||||||
Strain | WBStrain00029279 | ||||||
WBStrain00037184 | |||||||
WBStrain00006435 | |||||||
WBStrain00008389 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (31) | |||||||
Ortholog (43) | |||||||
Paralog | WBGene00004030 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
Structured_description | Concise_description | The unc-97 gene encodes a LIM domain-containing protein of the PINCH family that is highly similar to human LIMS1 (OMIM:602567) and LIMS2; UNC-97 functions as an adaptor protein important for assembly of muscle adherens junctions and the mechanosensory functions of the touch neurons; UNC-97 interacts with PAT-4/integrin-linked kinase and with UNC-98; UNC-97 colocalizes with PAT-3/beta integrin at dense bodies, focal adhesion-like muscle attachment structures. | Paper_evidence | WBPaper00003361 | |||
WBPaper00005261 | |||||||
WBPaper00005938 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson324 | |||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Enables myosin binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of sarcomere organization; and sensory perception of mechanical stimulus. Located in several cellular components, including adherens junction; basal plasma membrane; and contractile fiber. Expressed in body wall musculature and vulval muscle. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2W. Is an ortholog of human LIMS1 (LIM zinc finger domain containing 1) and LIMS2 (LIM zinc finger domain containing 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0110288 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16084) | ||
Molecular_info | Corresponding_CDS | F14D12.2 | |||||
Corresponding_transcript | F14D12.2.1 | ||||||
Other_sequence (52) | |||||||
Associated_feature (13) | |||||||
Transcription_factor | WBTranscriptionFactor000702 | ||||||
Experimental_info | RNAi_result (38) | ||||||
Expr_pattern | Chronogram707 | ||||||
Expr734 | |||||||
Expr5755 | |||||||
Expr8543 | |||||||
Expr14518 | |||||||
Expr1021966 | |||||||
Expr1032890 | |||||||
Expr1148541 | |||||||
Expr2017923 | |||||||
Expr2036059 | |||||||
Drives_construct | WBCnstr00000965 | ||||||
WBCnstr00000966 | |||||||
WBCnstr00002440 | |||||||
WBCnstr00012543 | |||||||
WBCnstr00013357 | |||||||
WBCnstr00019333 | |||||||
WBCnstr00034133 | |||||||
WBCnstr00041070 | |||||||
Construct_product | WBCnstr00000965 | ||||||
WBCnstr00012543 | |||||||
WBCnstr00013357 | |||||||
WBCnstr00016120 | |||||||
WBCnstr00016121 | |||||||
WBCnstr00019333 | |||||||
WBCnstr00034133 | |||||||
WBCnstr00041070 | |||||||
Antibody | WBAntibody00001194 | ||||||
Microarray_results (21) | |||||||
Expression_cluster (153) | |||||||
Interaction (55) | |||||||
Anatomy_function | WBbtf0611 | ||||||
WBProcess | WBbiopr:00000006 | ||||||
Map_info | Map | X | Position | -4.48479 | Error | 0.052884 | |
Well_ordered | |||||||
Positive | Positive_clone | F14D12 | Person_evidence | WBPerson260 | |||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
Negative | Outside_rearr | mcDf2 | |||||
Mapping_data | 2_point | 396 | |||||
397 | |||||||
Multi_point | 1207 | ||||||
5465 | |||||||
Pos_neg_data | 10697 | ||||||
Landmark_gene | |||||||
Reference (51) | |||||||
Remark | [Hobert O] This gene has 5 LIM domains and no homeobox domain, information in F14D12.2 is incorrect. Remark added by sdm 4/98. | ||||||
Method | Gene |