WormBase Tree Display for Gene: WBGene00006822

WBGene00006822 SMap: S_parent: Sequence: C46F11
  Identity: Version: 1
    Name: CGC_name: unc-93 Person_evidence: WBPerson261
      Sequence_name: C46F11.1
      Molecular_name: C46F11.1a
        C46F11.1a.1
        CE30906
        C46F11.1b
        CE37957
        C46F11.1b.1
      Other_name: CELE_C46F11.1 Accession_evidence: NDB BX284603
      Public_name: unc-93
    DB_info: Database: WormQTL gene WBGene00006822
        WormFlux gene WBGene00006822
        NDB locus_tag CELE_C46F11.1
        Panther gene CAEEL|WormBase=WBGene00006822|UniProtKB=Q93380
          family PTHR19444
        NCBI gene 175466
        RefSeq protein NM_001026047.5
            NM_001381807.1
        SwissProt UniProtAcc Q93380
        TREEFAM TREEFAM_ID TF314905
        UniProt_GCRP UniProtAcc Q93380
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00144047
    Allele (189)
    Legacy_information: Class 3 allele e1500sd : adults paralysed Egl; slightly long; abnormal muscle; contract and relax when prodded (`rubber-band' phenotype). ES3 ME0. Poor mating in e1500/+ males. NA (Class 3) 2 (n200 : resembles e1500 but less severe phenotype). Class 1 (loss-of-function) alleles n392 : no phenotype alone but fails to complement e1500. Intragenic revertants of e1500 all have Class 1 phenotype probably null alleles e.g. e1500n234amber. NA (Class 1) > 30. See also sup-9 sup-10 sup-11 sup-18.
      See also n192, n200, n201, n202, n203, n204, n205, n206, n207, n208, n209, n210, n211, n212, n214, n215, n216, n217, n218, n220, n224, n225, n226, n230, n231, n232, n234, n235, n236, n239, n243, n244, n246, n248, n254, n255, n256, n257, n259, n267, n268, n270, n291, n340, n341, n343, n344, n348, n349, n351, n352, n354, n392, n393, n394, n395, n396, n509, n511, n512, n516, n517, n520, n523, n618, n620, n623, n624, n626, n627, n629, n657, n660, n663, n665, n666, n667, n978, n979, n980, n981, n982, n1011, n1018, n1019, n1021, n1024, n1027
      [Reiner D]] Mac-d (Muscle ACtivation-Defective)
      [C.elegansII] e1500sd : adults paralysed, Egl; slightly long;abnormal muscle; contract and relax when prodded (`rubber-band' phenotype). Muscle activation defective (flaccid, long).ES3 ME0. Poor mating in e1500/+ males. Neomorphic allele, gf. OA1 (gf): n200(resembles e1500 but less severe phenotype).Both gf alleles suppressed by sup-9, sup-10,sup-11, sup-18. Also lf alleles: n392 (no phenotype alone but fails to complement e1500), n393 etc. Intragenic revertants of e1500 all have similar WT lf phenotype: e1500n234amb, des, e1500n200spo, e1500n243gri, e1500n1415::Tc1, etc. OA>30 (ird). Cloned: 2.2 kb transcripts (slightly different 5'), encoding 700 and 705 aa predicted novel proteins with multiple (5-10) possible TM domains. [Greenwald and Horvitz 1980; Levin and Horvitz 1992;MT]
    Strain (31)
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (39)
    Structured_description: Concise_description: unc-93 encodes a novel transmembrane protein that affects muscle contraction and egg laying; UNC-93 is predicted to be a component of a multi-protein complex containing the SUP-9 two-pore potassium channel and the SUP-10 transmembrane protein; an UNC-93::GFP fusion protein is expressed in body wall muscle membranes and dense bodies as well as in the vulval and intestinal muscles; neuronal UNC-93::GFP expression is found in the four SIA neurons that originate in the head, receive some synapses in the nerve ring, and extend posteriorly directed processes; in muscle cells, UNC-93::GFP colocalizes with SUP-9 to dense bodies and membranes. Paper_evidence: WBPaper00000486
            WBPaper00000564
            WBPaper00001525
            WBPaper00001800
            WBPaper00006135
          Curator_confirmed: WBPerson1843
            WBPerson324
          Date_last_updated: 26 Jun 2008 00:00:00
      Automated_description: Enables potassium channel regulator activity. Involved in regulation of muscle contraction and regulation of potassium ion transport. Located in plasma membrane and striated muscle dense body. Expressed in SIA; body wall musculature; and non-striated muscle. Is an ortholog of human UNC93A (unc-93 homolog A). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C46F11.1a
      C46F11.1b
    Corresponding_CDS_history: C46F11.1:wp80
      C46F11.1:wp138
      C46F11.1:wp140
    Corresponding_transcript: C46F11.1a.1
      C46F11.1b.1
    Other_sequence: FE914682.1
      FE913923.1
      Dviv_isotig29800
      ASC31488_1
      JI167429.1
    Associated_feature: WBsf991851
      WBsf991852
      WBsf991853
      WBsf991854
      WBsf224634
  Experimental_info: RNAi_result (12)
    Expr_pattern: Expr2773
      Expr2775
      Expr1019911
      Expr1032886
      Expr1146588
      Expr2017919
      Expr2036055
    Drives_construct (19)
    Construct_product (23)
    Microarray_results (23)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032425:down_in_zfp-1
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_larva_enriched
      WBPaper00037950:bodywall-muscle_larva_SelectivelyEnriched
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-15B(n744)_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045417:128Q-huntingtin_upreglated
      WBPaper00045521:Spermatogenic
      WBPaper00045861:set-2(ok952)_upregulated
      WBPaper00045861:wdr-5(ok1417)_upregulated
      WBPaper00046805:csr-1(RNAi)_upregulated_Set1
      WBPaper00046805:csr-1(RNAi)_upregulated_Set2
      WBPaper00048923:Aging_regulated
      WBPaper00050053:muscle_enriched_Day4
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053368:F.oxysporum_regulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
      WBPaper00056809:smn-1(ok355)_upregulated
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057288:iff-1(RNAi)_upregulated_transcript
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058691:cfp-1(tm6369)_upregulated
      WBPaper00058711:wdr-5(ok1417)_upregulated
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060871:M.humicola-infection_24h_regulated
      WBPaper00061340:mu_int_mu_anal
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:sol-1-jnk-1_18695
      WBPaper00061902:camt-1(ok515)_regulated_AFD
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064315:mes-3(bn199)_downregulated_EGCs
      WBPaper00064315:mes-4(bn73)_downregulated_EGCs
      WBPaper00064721:fasn-1(g14)_downregulated_starved
      WBPaper00065841:7_4
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4386_cluster_6_6
      cgc4489_group_6
      WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00031003:0hr_muscle_enriched
      WBPaper00031003:24hr_muscle_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036286:Pattern_F
      WBPaper00040184:hcf-1down_sir-2.1down_daf-2down
      WBPaper00040210:Chlorpyrifos_24C_regulated
      WBPaper00040876:mir-35_downregulated
      WBPaper00041174:environmental
      WBPaper00041174:environmental_prime
      WBPaper00041609:hpl-1_hpl-2_upregulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
    Interaction (54)
  Map_info: Map: III Position: -5.0882 Error: 0.020586
    Well_ordered
    Positive: Inside_rearr: nDf6
        nDf7
        nDf8
        nDf10
        nDf11
        nDf12
        nDf13
        nDf14
        nDf15
      Positive_clone: C46F11 Inferred_automatically: From sequence, transcript, pseudogene data
        MT#JL932
    Mapping_data: 2_point: 402
        403
        6037
        6039
        6040
      Multi_point (46)
      Pos_neg_data (11)
    Landmark_gene
  Reference (114)
  Method: Gene