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WormBase Tree Display for Gene: WBGene00006815

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Name Class

WBGene00006815SMapS_parentSequenceW01A11
IdentityVersion1
NameCGC_nameunc-83Person_evidenceWBPerson261
Sequence_nameW01A11.3
Molecular_name (11)
Other_nameCeGrip
CELE_W01A11.3Accession_evidenceNDBBX284605
Public_nameunc-83
DB_infoDatabaseWormQTLgeneWBGene00006815
WormFluxgeneWBGene00006815
OMIMdisease610743
612998
NDBlocus_tagCELE_W01A11.3
NCBIgene179033
RefSeqproteinNM_001392533.1
NM_001392532.1
NM_001083280.3
SwissProtUniProtAccQ23064
TREEFAMTREEFAM_IDTF352677
TrEMBLUniProtAccQ0PDL1
G8JYF1
UniProt_GCRPUniProtAccQ23064
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:43WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Reference_alleleWBVar00143983
AlleleWBVar00143983Inferred_automaticallyFrom strain object: CB1408
WBVar00088299Inferred_automaticallyFrom strain object: MH1301
WBVar00597530Inferred_automaticallyFrom strain object: VC2975
WBVar00090042
WBVar00089459
WBVar00145408
WBVar00090188
WBVar00143984
WBVar00089428
WBVar00089420
WBVar02147384
WBVar00089457
WBVar00090041
WBVar00089291
WBVar02147383
WBVar00090040
WBVar01018602
WBVar01018603
WBVar01018604
WBVar01018605
WBVar01018606
WBVar00067759
WBVar01018607
WBVar01018608
WBVar01018609
WBVar01018610
WBVar01018611
WBVar01018612
WBVar01018613
WBVar01018614
WBVar01018615
WBVar01018616
WBVar01018617
WBVar01018618
WBVar01018619
WBVar01018620
WBVar01018621
WBVar01018622
WBVar01018623
WBVar01018624
WBVar00261696
WBVar01018625
WBVar01018626
WBVar01018627
WBVar01499173
WBVar01018628
WBVar01499174
WBVar01018629
WBVar01710368
WBVar01018630
WBVar01018631
WBVar01018632
WBVar01018633
WBVar01018634
WBVar01018635
WBVar01018636
WBVar01018637
WBVar01018638
WBVar02136500
WBVar02136501
WBVar01018639
WBVar02136502
WBVar01018640
WBVar02136503
WBVar01018641
WBVar01018642
WBVar01499740
WBVar01018643
WBVar02023784
WBVar01018644
WBVar02023785
WBVar02023786
WBVar01018645
WBVar01808322
WBVar01018646
WBVar01808323
WBVar01018647
WBVar01018648
WBVar01808324
WBVar01018649
WBVar01808325
WBVar01808326
WBVar01018650
WBVar01808327
WBVar01018651
WBVar01808328
WBVar01018652
WBVar01808329
WBVar01018653
WBVar01018654
WBVar01808330
WBVar01808331
WBVar01018655
WBVar01018656
WBVar01018657
WBVar00065470
WBVar01018658
WBVar01018659
WBVar01018660
WBVar01018661
WBVar01018662
WBVar01500129
WBVar01018663
WBVar01018664
WBVar01617405
WBVar01018665
WBVar01018666
WBVar01460256
WBVar01018667
WBVar01460258
WBVar01018668
WBVar00255113
WBVar00460559
WBVar01460259
WBVar01018669
WBVar01018670
WBVar00460560
WBVar01460260
WBVar00460561
WBVar01018671
WBVar01460261
WBVar00460562
WBVar01460262
WBVar01018672
WBVar00460563
WBVar01018673
WBVar00460564
WBVar00460565
WBVar01740716
WBVar00460566
WBVar01740717
WBVar00460567
WBVar01740718
WBVar01740719
WBVar00460568
WBVar00460569
WBVar00460570
WBVar00460571
WBVar00460572
WBVar00460573
WBVar00460574
WBVar00460575
WBVar00460576
WBVar00460577
WBVar00460578
WBVar00460579
WBVar00460580
WBVar00460581
WBVar00460582
WBVar00460583
WBVar00460584
WBVar00460585
WBVar00460586
WBVar00460587
WBVar00460588
WBVar00460589
WBVar00460590
WBVar02076108
WBVar00460591
WBVar00460592
WBVar01018518
WBVar00460593
WBVar01018519
WBVar00460594
WBVar01018520
WBVar00460595
WBVar01018521
WBVar00460596
WBVar01018522
WBVar00460597
WBVar01018523
WBVar01018524
WBVar00460598
WBVar00246551
WBVar01018525
WBVar00460599
WBVar00246552
WBVar00460600
WBVar01018526
WBVar00460601
WBVar01018527
WBVar01018528
WBVar00460602
WBVar00460603
WBVar01018529
WBVar00460604
WBVar01018530
WBVar00460605
WBVar01018531
WBVar00460606
WBVar01018532
WBVar00460607
WBVar01800102
WBVar01018533
WBVar01018534
WBVar00460608
WBVar01018535
WBVar01973845
WBVar00460609
WBVar00460610
WBVar01973846
WBVar00586837
WBVar01018536
WBVar01429584
WBVar01018537
WBVar00460611
WBVar00586838
WBVar01973847
WBVar00460612
WBVar01018538
WBVar00586840
WBVar01018539
WBVar00586845
WBVar00460613
WBVar01018540
WBVar00586847
WBVar02056288
WBVar00460614
WBVar01018541
WBVar01018542
WBVar01018543
WBVar02043457
WBVar01018544
WBVar01018545
WBVar00255358
WBVar01018546
WBVar01018547
WBVar00272113
WBVar01018548
WBVar01018549
WBVar01018550
WBVar01018551
WBVar01018552
WBVar01018553
WBVar01018554
WBVar01018555
WBVar01018556
WBVar02110615
WBVar01018557
WBVar01018558
WBVar01018559
WBVar00601179
WBVar01018560
WBVar01018561
WBVar01018562
WBVar01018563
WBVar01018564
WBVar01018565
WBVar00210569
WBVar01018566
WBVar00210570
WBVar01018567
WBVar00210571
WBVar01018568
WBVar00210572
WBVar00210573
WBVar01018569
WBVar00210574
WBVar01018570
WBVar01018571
WBVar00210575
WBVar01018572
WBVar00210576
WBVar00240650
WBVar00210577
WBVar01018573
WBVar00210578
WBVar01018574
WBVar00210579
WBVar01018575
WBVar00277400
WBVar01018576
WBVar00210580
WBVar00210581
WBVar00277401
WBVar01018577
WBVar01018578
WBVar00210582
WBVar01499677
WBVar01018579
WBVar00210583
WBVar01018580
WBVar00210584
WBVar01499678
WBVar00210585
WBVar01018581
WBVar00210586
WBVar01018582
WBVar01499496
WBVar00210587
WBVar02152693
WBVar01703118
WBVar01018583
WBVar01018584
WBVar01018585
WBVar01499316
WBVar01018586
WBVar01018587
WBVar01018588
WBVar01775225
WBVar00257244
WBVar01018589
WBVar01018590
WBVar01018591
WBVar01018592
WBVar01018593
WBVar01018594
WBVar01018595
WBVar01018596
WBVar01018597
WBVar01018598
WBVar01018599
WBVar01500066
WBVar01018600
WBVar01018601
Legacy_informatione1408ts : reverse kinker as adult variably Egl; L1 moves well; variable failures in postembryonic migration of Pn nuclei into ventral cord and (some alleles) embryonic migrations of hyp-7 hypodermal nuclei; all alleles are ts for Pn defect non-ts for hyp-7 defect; unmigrated Pn nuclei mostly fail to divide; adult male phenotype variable some can mate at 25x all can mate at 15x. ES3 ME3 (15x). NA11 (n331amber ts; e1409amber ts (suppressible only for hyp-7 defect)).
See also e1408, e1409, n159, n1216, n1217, n1218
[C.elegansII] e1408ts : reverse kinker as adult, variably Egl; L1 moves well; variable failures in postembryonic migration of Pn nuclei into ventral cord and (some alleles) embryonic migrations of hyp-7 hypodermal nuclei; all alleles are ts for Pn defect,non-ts for hyp-7 defect; unmigrated Pn nuclei mostly fail to divide; adult male phenotype variable, some can mate at 25C, all can mate at 15C. ES3 ME3 (15C). NA11: n331amb,ts, e1409amb,ts (suppressible only for hyp-7 defect), n159, n1218 etc. [Sulston and Horvitz 1981; MH; MT]
StrainWBStrain00026512
WBStrain00037609
WBStrain00037683
WBStrain00004325
RNASeq_FPKM (74)
GO_annotation (27)
Ortholog (26)
Structured_descriptionConcise_descriptionunc-83 encodes a KASH domain-containing transmembrane protein; during development, UNC-83 is required for nuclear migrations in P cells, hyp7 hypodermal precursors, and intestinal cells and thus, for ventral nerve cord development, locomotion, and vulval formation; specifically, UNC-83 functions to recruit kinesin and dynein motor complexes to the nuclear envelope to regulate the directionality and extent of nuclear migrations; UNC-83 localizes to the outer nuclear membrane and its localization is dependent upon the SUN domain of UNC-84, an inner nuclear membrane protein with which it interacts in vitro; UNC-83 and UNC-84 are thus proposed to link the nuclear lamina with the cytoskeleton to properly effect nuclear migrations.Paper_evidenceWBPaper00000496
WBPaper00003628
WBPaper00005053
WBPaper00005172
WBPaper00027107
WBPaper00035598
Curator_confirmedWBPerson1843
Date_last_updated23 Apr 2010 00:00:00
Automated_descriptionEnables dynein light chain binding activity. Involved in several processes, including cellular localization; egg-laying behavior; and vulval development. Located in nuclear outer membrane. Expressed in several structures, including P1; P12; P2; P3; and P9. Used to study Emery-Dreifuss muscular dystrophy.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:11726Homo sapiensPaper_evidenceWBPaper00040268
Accession_evidenceOMIM612998
Curator_confirmedWBPerson324
Date_last_updated14 Feb 2013 00:00:00
Disease_relevanceStudies in elegans have contributed much to the knowledge of SUN-KASH protein complexes which link components of the nucleus to the cytoplasm; KASH domain proteins in elegans are involved in nuclear positioning and migration; the family of mammalian KASH (klarsicht, ANC-1 and Syne) domain proteins include Nesprin-1/SYNE1, Nesprin-2/SYNE2, Nesprin-3/SYNE3 and Nesprin-4/SYNE4) that encode at least 12 isoforms, by alternative transcription and splicing; most KASH domain proteins do not share primary sequence homology outside of their KASH domain; mutations in SYNE1, similar to those in LMNA/Lamin, cause laminopathic diseases like Emery-Dreifuss muscular dystrophy (EDMD) and Spinocerebellar ataxia.Homo sapiensPaper_evidenceWBPaper00040268
Accession_evidenceOMIM612998
610743
Curator_confirmedWBPerson324
Date_last_updated19 Mar 2012 00:00:00
Models_disease_in_annotationWBDOannot00000051
Molecular_infoCorresponding_CDSW01A11.3a
W01A11.3b
W01A11.3c
Corresponding_CDS_historyW01A11.3:wp162
Corresponding_transcriptW01A11.3a.1
W01A11.3b.1
W01A11.3b.2
W01A11.3c.1
W01A11.3c.2
Other_sequence (22)
Associated_feature (57)
Experimental_infoRNAi_resultWBRNAi00090325Inferred_automaticallyRNAi_primary
WBRNAi00062672Inferred_automaticallyRNAi_primary
WBRNAi00090007Inferred_automaticallyRNAi_primary
WBRNAi00054484Inferred_automaticallyRNAi_primary
WBRNAi00065283Inferred_automaticallyRNAi_primary
WBRNAi00054483Inferred_automaticallyRNAi_primary
WBRNAi00089756Inferred_automaticallyRNAi_primary
WBRNAi00090166Inferred_automaticallyRNAi_primary
WBRNAi00062671Inferred_automaticallyRNAi_primary
WBRNAi00019442Inferred_automaticallyRNAi_primary
Expr_patternChronogram318
Expr1789
Expr6810
Expr13170
Expr1023585
Expr1032880
Expr1158032
Expr2017912
Expr2036048
Drives_constructWBCnstr00002621
AntibodyWBAntibody00000447
WBAntibody00002169
Microarray_results (31)
Expression_cluster (171)
Interaction (107)
Map_infoMapVPosition-0.105154Error0.00884
Well_ordered
PositiveInside_rearrnDf32
nDf1
nDf18
nDf33
Positive_cloneW01A11Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point311
Multi_point (6)
Pos_neg_data843
1735
1748
6813
6814
Reference (75)
MethodGene