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WormBase Tree Display for Gene: WBGene00006808

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Name Class

WBGene00006808SMapS_parentSequenceC01G10
IdentityVersion1
NameCGC_nameunc-76Person_evidenceWBPerson261
Sequence_nameC01G10.11
Molecular_name (18)
Other_nameCELE_C01G10.11Accession_evidenceNDBBX284605
Public_nameunc-76
DB_infoDatabaseAceViewgene5P559
WormQTLgeneWBGene00006808
WormFluxgeneWBGene00006808
NDBlocus_tagCELE_C01G10.11
PanthergeneCAEEL|WormBase=WBGene00006808|UniProtKB=E0AHC6
familyPTHR12394
NCBIgene180014
RefSeqproteinNM_001269717.3
NM_001269716.3
NM_001269719.3
NM_001269718.3
NM_074311.7
NM_171553.6
TREEFAMTREEFAM_IDTF313128
TrEMBLUniProtAccE0AHC6
E0AHC4
E0AHC3
E0AHC5
Q7JL61
Q7JL62
UniProt_GCRPUniProtAccE0AHC6
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:43WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Reference_alleleWBVar00143591
AlleleWBVar00241549Inferred_automaticallyFrom strain object: NJ388
WBVar00088429
WBVar02146341
WBVar02146342
WBVar01463220
WBVar01463221
WBVar01463222
WBVar01463223
WBVar01499705
WBVar01463224
WBVar01463225
WBVar01463226
WBVar01463227
WBVar01463228
WBVar00143591
WBVar00018205
WBVar01800191
WBVar01744712
WBVar01800192
WBVar01744713
WBVar01800193
WBVar00018210
WBVar01828413
WBVar01800194
WBVar01800195
WBVar01800196
WBVar00018215
WBVar01800197
WBVar01800198
WBVar01975608
WBVar00018220
WBVar01800199
WBVar01975609
WBVar01975610
WBVar01800200
WBVar01975611
WBVar01800201
WBVar00018225
WBVar01975612
WBVar01800202
WBVar01975613
WBVar00018230
WBVar00018235
WBVar02109411
WBVar00018240
WBVar02109412
WBVar00018245
WBVar02107392
WBVar00018250
WBVar00018255
WBVar00018260
WBVar02024715
WBVar00018265
WBVar00600891
WBVar01775667
WBVar01775668
WBVar01809074
WBVar01809075
WBVar01775669
WBVar01775670
WBVar01809076
WBVar01703200
WBVar01775671
WBVar01775672
WBVar01071513
WBVar01071514
WBVar01071515
WBVar01071516
WBVar01071517
WBVar01071518
WBVar01485059
WBVar01071519
WBVar01071520
WBVar01071521
WBVar01071522
WBVar01071523
WBVar00145227
WBVar01071524
WBVar01071525
WBVar01071526
WBVar01071527
WBVar00090458
WBVar01071528
WBVar00090459
WBVar01071529
WBVar01071530
WBVar01071531
WBVar01071532
WBVar01071533
WBVar01071534
WBVar01071535
WBVar01071536
WBVar01071537
WBVar01071538
WBVar01071539
WBVar01071540
WBVar01071541
WBVar01071542
WBVar01071543
WBVar01071544
WBVar02078171
WBVar01071545
WBVar01071546
WBVar01071547
WBVar01071548
WBVar01071549
WBVar01071550
WBVar01071551
WBVar01071552
WBVar00090488
WBVar01071553
WBVar01489509
WBVar01071554
WBVar01071555
WBVar01071556
WBVar01071557
WBVar01071558
WBVar01071559
WBVar01071560
WBVar01071561
WBVar01071562
WBVar01071563
WBVar02038828
WBVar02038829
WBVar02048306
WBVar01590520
WBVar01590521
WBVar00478291
WBVar00478292
WBVar01474431
WBVar00478293
WBVar02032064
WBVar02032065
WBVar00478294
WBVar02032066
WBVar00478295
WBVar00478296
WBVar02032067
WBVar00478297
WBVar02032068
WBVar02032069
WBVar00478298
WBVar00478299
WBVar01500212
WBVar00478300
WBVar01500213
WBVar00478301
WBVar00478302
WBVar00478303
WBVar00478304
WBVar00478305
WBVar00478306
WBVar01499299
WBVar00478307
WBVar00478308
WBVar00478309
WBVar00478310
WBVar00478311
WBVar00478312
WBVar01499316
WBVar01402376
WBVar02034601
WBVar01499698
Legacy_informatione911pdi : inactive tends to curl dumpyish; Egl-c; amphid phasmid PDE axons abnormal; dorsal extensions of DD and VD neurons frequently grow in abnormal directions often fail to connect to dorsal nerve cord. ES3 ME0. NA1.
[C.elegansII] e911pdi : inactive, tends to curl, dumpyish; Egl-c; amphid, phasmid, PDE, PVP, other axons abnormal; dorsal extensions of DD and VD neurons frequently grow in abnormal directions, often fail to connect to dorsal nervecord. Defects in axonal elongation and fasciculation along nerve cords. ES3 ME0. NA1. Cloned: 1.8 kb transcripts, encode predicted 385 or 376 aa novel proteins. Epitope-tagged UNC-76 detected in axons. [Hedgecock et al. 1985; McIntire et al. 1992; MT]
Strain (54)
RNASeq_FPKM (74)
GO_annotation (22)
Ortholog (39)
Structured_descriptionConcise_descriptionunc-76 encodes a predicted coiled-coil protein that belongs to the FEZ (fasciculation and elongation protein; zygin/zeta-1) family of proteins; UNC-76 activity is required for normal axonal outgrowth and fasciculation and hence, normal locomotion; UNC-76 expression begins during embryogenesis and is present in all axons throughout development; UNC-76 localizes to both axons and cell bodies.Paper_evidenceWBPaper00002751
Curator_confirmedWBPerson1843
Date_last_updated31 May 2006 00:00:00
Automated_descriptionEnables syntaxin binding activity. Involved in anterograde axonal protein transport; axonal fasciculation; and regulation of cellular component organization. Located in axon; neuronal cell body; and perinuclear region of cytoplasm. Expressed in neurons and somatic nervous system. Human ortholog(s) of this gene implicated in schizophrenia. Is an ortholog of human FEZ1 (fasciculation and elongation protein zeta 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:5419Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3659)
Molecular_infoCorresponding_CDSC01G10.11a
C01G10.11b
C01G10.11c
C01G10.11d
C01G10.11e
C01G10.11f
Corresponding_CDS_historyC01G10.11a:wp151
C01G10.11b:wp151
Corresponding_transcriptC01G10.11a.1
C01G10.11b.1
C01G10.11c.1
C01G10.11d.1
C01G10.11e.1
C01G10.11f.1
Other_sequence (20)
Associated_feature (21)
Experimental_infoRNAi_result (8)
Expr_patternExpr1621
Expr1019687
Expr1032875
Expr1143433
Expr2017905
Expr2036041
Drives_constructWBCnstr00001401
WBCnstr00034141
Construct_product (15)
AntibodyWBAntibody00000143
Microarray_results (40)
Expression_cluster (180)
Interaction (37)
Map_infoMapVPosition7.32052Error0.012665
Well_ordered
PositivePositive_cloneC01G10Inferred_automaticallyFrom sequence, transcript, pseudogene data
C08C1Inferred_automaticallyFrom sequence, transcript, pseudogene data
NegativeOutside_rearrnDf31
ozDf1
Mapping_data2_point (15)
Multi_point (103)
Pos_neg_data4288
4289
4290
4304
8977
Landmark_gene
Reference (130)
MethodGene