WormBase Tree Display for Gene: WBGene00006789

WBGene00006789 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 1
    Name: CGC_name: unc-54 Person_evidence: WBPerson261
      Sequence_name: F11C3.3
      Molecular_name: F11C3.3
        F11C3.3.1
        CE09349
      Other_name: myo-4
        CELE_F11C3.3 Accession_evidence: NDB BX284601
      Public_name: unc-54
    DB_info: Database: AceView gene 1P454
        WormQTL gene WBGene00006789
        WormFlux gene WBGene00006789
        NDB locus_tag CELE_F11C3.3
        Panther gene CAEEL|WormBase=WBGene00006789|UniProtKB=P02566
          family PTHR45615
        NCBI gene 259839
        RefSeq protein NM_061195.7
        SwissProt UniProtAcc P02566
        UniProt_GCRP UniProtAcc P02566
        OMIM gene 160710
            160720
            160740
            160741
            160760
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:42 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Allele (386)
    Legacy_information: Structural gene for major body wall myosin heavy chain. Reference null allele e190 : limp paralysed phenotype at all stages larvae can move slightly more than adults Egl; muscle ultrastructure very disorganized few thick filaments. ES3 ME0. NA (recessive) > 50 including e1108amber; e1301ts; e675sd and s291 (in frame internal deletion mutants with heavy chain fragment behavioral phenotype almost paralysed slight twitcher); also Tc1 insertion mutants; etc. Also unusual suppressor alleles (NA > 15) e.g. s74 : dominant suppressor of unc-22(s12) no other dominant phenotype recessive phenotype slow stiff normal muscle ultrastructure; alteration in S1 portion of protein. Also Class 3 (dominant) alleles reference allele e1152sd : severe rigid paralysis small; e1152/+ paralysed weaker phenotype. ES3 ME0. NA (dominant) > 10 : e1153 n489 etc.; resemble e1152 or more severe recessive lethal. Intragenic revertants have Class 1 phenotypes.
      See unc-54.
      See also e569, e576, e651, e675, e843, e903, e1008, e1009, e1021, e1092, e1108, e1115, e1152, e1153, e1157, e1168, e1201, e1213, e1219, e1223, e1257, e1258, e1273, e1274, e1300, e1301, e1311, e1315, e1328, e1360, e1419, e1420, n325, n326, n327, n489, n794, r274, r308, r322, r323, r327, r360, s74, s75, s76, s77, s78, s95, s291, s409, s411
      [C.elegansII] e190 : limp paralysed phenotype at all stages; larvae can move slightly more than adults; Egl; muscle ultrastructure very disorganized few thick filaments. ES3 ME0. OA>50 (recessive): e1108amb,e1301ts, e675sd and s291 (in frame internal deletion mutants, almost paralysed slight twitchers), etc. Also unusual suppressor alleles, OA>15: s74 (dominant suppressor of unc-22(s12), recessive slow, stiff; normal muscle ultrastructure) Also dominant antimorphic alleles, OA>10:e1152sd (severe rigid paralysis, small;e1152/+ paralysed weaker phenotype. ES3 ME0),r344 (recessive lethal, r344/+ severely paralysed), etc. Intragenic revertants have recessive paralysed phenotype. Some recessive alleles (r274, e1420 etc.) are dominant antimorphs in smg background. Cloned: encodes MHC B (MYO-4), major bodywall muscle myosin heavy chain. 6 kb message,1117 aa protein. Extensive molecular analysis. [Epstein et al. 1974; McLachlan and Karn 1982;Dibb et al. 1989; Bejsovec and Anderson 1990; TR; RW]
    Strain (1380)
    RNASeq_FPKM (74)
    GO_annotation (31)
    Ortholog: WBGene00060889 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00023596 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00025170 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00030079 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00032487 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00035391 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00038900 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00040055 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00040581 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00041777 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00147183 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00117763 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00131142 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00223568 Brugia malayi From_analysis: WormBase-Compara
      WBGene00224377 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g9085 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g6392 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g5864 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g8240 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g4259 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g22272 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g9281 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g14410 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g1808 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g12497 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_15248.g24974 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cnig_chr_I.g3807 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold572.g4325 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01801.g23223 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_06941.g37197 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_09136 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_001454 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g02608 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g2033 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_10010600 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrI_pilon.g2982 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00242128 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00246956 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00266272 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00292203 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000001065 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      FB:FBgn0264695 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-991123-5 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-000322-5 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-020604-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-030131-271 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-030131-6206 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-031112-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-090311-5 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-061027-393 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-070705-73 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-081124-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-070705-74 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-070822-12 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-060531-50 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-100914-2 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:7567 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:7572 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:7573 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:7574 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:7576 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:7577 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:7578 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:7571 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:31073 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:15906 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1339711 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1339710 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1339709 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1339713 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1339712 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:97255 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:2155600 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1339967 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:3643515 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:3710243 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:3138 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:62029 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:62030 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1565858 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1307994 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:3139 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
    Paralog (21)
    Structured_description: Concise_description: unc-54 encodes a muscle myosin class II heavy chain (MHC B); UNC-54 is the major myosin heavy chain expressed in C. elegans and is required for locomotion and egg-laying; in vivo and in vitro, UNC-54 interacts with ITR-1, an IP3 receptor, and this interaction may provide a link between calcium signaling and the muscle cytoskeleton; UNC-54 is a thick filament component that is expressed in multiple muscle cell classes including body wall, intestinal, anal depressor, and sphincter muscles as well as sex-specific muscles that develop postembryonically. Paper_evidence: WBPaper00000232
            WBPaper00000647
            WBPaper00001014
            WBPaper00005299
            WBPaper00005940
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables actin filament binding activity and microfilament motor activity. A structural constituent of muscle. Involved in several processes, including egg-laying behavior; muscle contraction; and skeletal muscle myosin thick filament assembly. Located in A band and striated muscle myosin thick filament. Part of muscle myosin complex. Expressed in anal depressor muscle; body wall musculature; head; vulval muscle; and in male. Human ortholog(s) of this gene implicated in several diseases, including congenital heart disease (multiple); distal myopathy 1; and intrinsic cardiomyopathy (multiple). Is an ortholog of several human genes including MYH1 (myosin heavy chain 1); MYH2 (myosin heavy chain 2); and MYH3 (myosin heavy chain 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (30)
  Molecular_info: Corresponding_CDS: F11C3.3
    Corresponding_transcript: F11C3.3.1
    Other_sequence (386)
    Associated_feature (32)
  Experimental_info: RNAi_result (12)
    Expr_pattern (15)
    Drives_construct (151)
    Construct_product: WBCnstr00011688
      WBCnstr00011704
      WBCnstr00013869
      WBCnstr00015881
      WBCnstr00018819
      WBCnstr00034149
    Antibody (11)
    Microarray_results (22)
    Expression_cluster (308)
    Interaction (231)
    WBProcess: WBbiopr:00000040
  Map_info: Map: I Position: 27.9607 Error: 0.002243
    Well_ordered
    Positive: Inside_rearr: eDf3
        eDf10
        dxDf2
      Positive_clone: F11C3 Inferred_automatically: From sequence, transcript, pseudogene data
        SG25/36
    Mapping_data: 2_point (22)
      Multi_point (47)
      Pos_neg_data (20)
    Landmark_gene
  Reference (599)
  Remark: unc-54 posneg pcr data gives map conflict, spans deletion breakpoint ? jah 8.97
  Method: Gene