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WormBase Tree Display for Gene: WBGene00006789

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Name Class

WBGene00006789SMapS_parentSequenceCHROMOSOME_I
IdentityVersion1
NameCGC_nameunc-54Person_evidenceWBPerson261
Sequence_nameF11C3.3
Molecular_nameF11C3.3
F11C3.3.1
CE09349
Other_namemyo-4
CELE_F11C3.3Accession_evidenceNDBBX284601
Public_nameunc-54
DB_infoDatabaseAceViewgene1P454
WormQTLgeneWBGene00006789
WormFluxgeneWBGene00006789
NDBlocus_tagCELE_F11C3.3
PanthergeneCAEEL|WormBase=WBGene00006789|UniProtKB=P02566
familyPTHR45615
NCBIgene259839
RefSeqproteinNM_061195.7
SwissProtUniProtAccP02566
UniProt_GCRPUniProtAccP02566
OMIMgene160710
160720
160740
160741
160760
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:42WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Allele (386)
Legacy_informationStructural gene for major body wall myosin heavy chain. Reference null allele e190 : limp paralysed phenotype at all stages larvae can move slightly more than adults Egl; muscle ultrastructure very disorganized few thick filaments. ES3 ME0. NA (recessive) > 50 including e1108amber; e1301ts; e675sd and s291 (in frame internal deletion mutants with heavy chain fragment behavioral phenotype almost paralysed slight twitcher); also Tc1 insertion mutants; etc. Also unusual suppressor alleles (NA > 15) e.g. s74 : dominant suppressor of unc-22(s12) no other dominant phenotype recessive phenotype slow stiff normal muscle ultrastructure; alteration in S1 portion of protein. Also Class 3 (dominant) alleles reference allele e1152sd : severe rigid paralysis small; e1152/+ paralysed weaker phenotype. ES3 ME0. NA (dominant) > 10 : e1153 n489 etc.; resemble e1152 or more severe recessive lethal. Intragenic revertants have Class 1 phenotypes.
See unc-54.
See also e569, e576, e651, e675, e843, e903, e1008, e1009, e1021, e1092, e1108, e1115, e1152, e1153, e1157, e1168, e1201, e1213, e1219, e1223, e1257, e1258, e1273, e1274, e1300, e1301, e1311, e1315, e1328, e1360, e1419, e1420, n325, n326, n327, n489, n794, r274, r308, r322, r323, r327, r360, s74, s75, s76, s77, s78, s95, s291, s409, s411
[C.elegansII] e190 : limp paralysed phenotype at all stages; larvae can move slightly more than adults; Egl; muscle ultrastructure very disorganized few thick filaments. ES3 ME0. OA>50 (recessive): e1108amb,e1301ts, e675sd and s291 (in frame internal deletion mutants, almost paralysed slight twitchers), etc. Also unusual suppressor alleles, OA>15: s74 (dominant suppressor of unc-22(s12), recessive slow, stiff; normal muscle ultrastructure) Also dominant antimorphic alleles, OA>10:e1152sd (severe rigid paralysis, small;e1152/+ paralysed weaker phenotype. ES3 ME0),r344 (recessive lethal, r344/+ severely paralysed), etc. Intragenic revertants have recessive paralysed phenotype. Some recessive alleles (r274, e1420 etc.) are dominant antimorphs in smg background. Cloned: encodes MHC B (MYO-4), major bodywall muscle myosin heavy chain. 6 kb message,1117 aa protein. Extensive molecular analysis. [Epstein et al. 1974; McLachlan and Karn 1982;Dibb et al. 1989; Bejsovec and Anderson 1990; TR; RW]
Strain (1380)
RNASeq_FPKM (74)
GO_annotation (31)
Ortholog (82)
Paralog (21)
Structured_descriptionConcise_descriptionunc-54 encodes a muscle myosin class II heavy chain (MHC B); UNC-54 is the major myosin heavy chain expressed in C. elegans and is required for locomotion and egg-laying; in vivo and in vitro, UNC-54 interacts with ITR-1, an IP3 receptor, and this interaction may provide a link between calcium signaling and the muscle cytoskeleton; UNC-54 is a thick filament component that is expressed in multiple muscle cell classes including body wall, intestinal, anal depressor, and sphincter muscles as well as sex-specific muscles that develop postembryonically.Paper_evidenceWBPaper00000232
WBPaper00000647
WBPaper00001014
WBPaper00005299
WBPaper00005940
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables actin filament binding activity and microfilament motor activity. A structural constituent of muscle. Involved in several processes, including egg-laying behavior; muscle contraction; and skeletal muscle myosin thick filament assembly. Located in A band and striated muscle myosin thick filament. Part of muscle myosin complex. Expressed in anal depressor muscle; body wall musculature; head; vulval muscle; and in male. Human ortholog(s) of this gene implicated in several diseases, including congenital heart disease (multiple); distal myopathy 1; and intrinsic cardiomyopathy (multiple). Is an ortholog of several human genes including MYH1 (myosin heavy chain 1); MYH2 (myosin heavy chain 2); and MYH3 (myosin heavy chain 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (30)
Molecular_infoCorresponding_CDSF11C3.3
Corresponding_transcriptF11C3.3.1
Other_sequence (386)
Associated_feature (32)
Experimental_infoRNAi_result (12)
Expr_pattern (15)
Drives_construct (151)
Construct_productWBCnstr00011688
WBCnstr00011704
WBCnstr00013869
WBCnstr00015881
WBCnstr00018819
WBCnstr00034149
Antibody (11)
Microarray_results (22)
Expression_clusterWBPaper00024704:Soluble_protein
WBPaper00029359_1291
WBPaper00032528:L3_enriched
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00033208:STI-1_interacting
WBPaper00036662:oxidative_modification
WBPaper00037047:insoluble_protein
WBPaper00037682:sma-2_sma-4_upregulated
WBPaper00037946:LIN-39_interacting
WBPaper00038118:aak-2(gt33)_upregulated
WBPaper00038118:stress_upregulated_N2
WBPaper00038213:E.coli(LF82)_24h_upregulated
WBPaper00038289:oocyte_protein
WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
WBPaper00042561:smgl-1(RNAi)_upregulated
WBPaper00043951:insoluble_protein_day16_N2
WBPaper00044128:daf-2(e1370)_upregulated
WBPaper00044128:DietaryRestriction_upregulated
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044578:reduced-humidity_downregulated_microarray
WBPaper00044736:flat_dev_expression
WBPaper00044746:aging_downregulated_Day5
WBPaper00044746:aging_downregulated_HeatShock
WBPaper00045314:S.aureus-induced_N2
WBPaper00045521:Gender_Neutral
WBPaper00045565:BIR-1_induced
WBPaper00045571:germline-ablation_upregulated
WBPaper00045693:S.flexneri_upregulated
WBPaper00046012:tdp-1(ok803)_downregulated
WBPaper00046121:mesoderm_unique
WBPaper00046217:clk-1(qm30)_upregulated
WBPaper00046446:slow-synthesized_YoungAdult
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046509:lin-35(n745)_downregulated
WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
WBPaper00047131:daf-2(e1370)_upregulated_N2-background
WBPaper00048910:mRNA-interacting_protein
WBPaper00048988:neuron_expressed
WBPaper00049001:EVN_enriched
WBPaper00049626:UNC-75_target
WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
WBPaper00049920:Glucose-Diet_upregulated_N2
WBPaper00049920:hyl-2(tm2031)_upregulated
WBPaper00049942:HeatShock_upregulated_hsf-1(+)
WBPaper00049954:BPS_downregulated
WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
WBPaper00050182:lmn-1(L535P)_downregulated
WBPaper00050225:flp-6(RNAi)_upregulated
WBPaper00050344:AFD-neuron_enriched
WBPaper00050344:ASER-neuron_enriched
WBPaper00050344:PLM-neuron_enriched
WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050496:unc-39(hp701)_regulated
WBPaper00050686:glp-1(e2141)_upregulated
WBPaper00050698:DEP-1_interacting
WBPaper00050726:starvation_regulated_LowSalt
WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:germline_enriched
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:body-wall-muscle_nucleus_expressed
WBPaper00051245:cytoplasm_specific
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051265:F4_hrde-1(tm1200)_downregulated
WBPaper00051538:micro-gavity_downregulated_protein
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053318:Aging_downregulated_mRNA_N2
WBPaper00053321:embryo-to-L1_upregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
WBPaper00053321:mes-4(RNAi)_downregulated_fed-L1_Truseq
WBPaper00053321:PGCs_depleted_NuGen
WBPaper00053388:dauer_regulated_Cluster1
WBPaper00053599:female_vs_male_downregulated
WBPaper00053814:15C_downregulated_PY79
WBPaper00054189:aging_regulated_protein
WBPaper00054189:P.aeruginosa_regulated_protein
WBPaper00054493:hpl-2(tm1489)_upregulated
WBPaper00055049:S.gordonii_upregulated
WBPaper00055103:thoc-5(wy822)_downregulated
WBPaper00055334:DLC-1_interacting
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Psora_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055482:Tunicamycin_downregulated
WBPaper00055565:AVK_enriched
WBPaper00055626:pry-1(mu38)_downregulated
WBPaper00055648:male-vas-deferens_expressed
WBPaper00055827:pfd-6(gk493446)_downregulated
WBPaper00055897:heat-shock_upregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056039:hda-6(ok3203)_upregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056139:gut-microbiota_downregulated
WBPaper00056218:daf-16(mu86)_upregulated_Day3
WBPaper00056275:P.aeruginosa_downregulated
WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
WBPaper00056443:DietaryRestriction_downregulated
WBPaper00056619:CEPsh_enriched
WBPaper00056826:hmc_biased
WBPaper00056900:ERH-2_interacting
WBPaper00056900:PID-3_interacting
WBPaper00056900:TOFU-6_interacting
WBPaper00056900:TOST-1_interacting
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057006:DietaryRestriction_upregulated
WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated
WBPaper00057143:ztf-11(RNAi)_upregulated
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058678:DAF-12_upregulated_PVD
WBPaper00058691:CFP-1_interacting_protein
WBPaper00058958:100mGy-irradiation-72h_upregulated
WBPaper00059231:alh-6(lax105)_D3Adult_upregulated
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059328:mrps-5(RNAi)_upregulated_protein
WBPaper00059566:wdr-23(mac32)_upregulated
WBPaper00059605:MUT-16_interacting
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059728:5ug_cholesterol_upregulated
WBPaper00059728:20ug_cholesterol_upregulated
WBPaper00059824:rnp-6(dh1127)_regulated_OP50
WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
WBPaper00059839:S.maltophilia_regulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060084:DVE-1_interacting_protein_cco-1(RNAi)
WBPaper00060084:DVE-1_interacting_protein_control
WBPaper00060100:SiNP_upregulated_mRNA
WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060445:nfki-1(cer1)_downregulated_L1
WBPaper00060661:sensory-neuron_depleted
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00060908:TEBP-1_interacting
WBPaper00060908:TEBP-2_interacting
WBPaper00061040:FW1256_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061285:wounding_24h_downregulated
WBPaper00061340:BWM_anterior
WBPaper00061340:BWM_far_posterior
WBPaper00061340:mu_int_mu_anal
WBPaper00061340:mu_sph
WBPaper00061377:MYRF-1_interacting
WBPaper00061377:MYRF-2_interacting
WBPaper00061377:PAN-1_interacting
WBPaper00061424:Diet_MYb120_upregulated
WBPaper00061439:unc-30(ok613)_upregulated
WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
WBPaper00061466:nath-10(icb99)_upregulated
WBPaper00061466:nath-10(icb102)_upregulated
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061479:prg-1(tm872)_upregulated
WBPaper00061479:ubc-9(ne4833)_upregulated
WBPaper00061527:mup-2-unc-87_284
WBPaper00061651:ADF_enriched
WBPaper00061651:ADL_enriched
WBPaper00061651:AIZ_enriched
WBPaper00061651:ALN_enriched
WBPaper00061651:ASG_enriched
WBPaper00061651:ASH_enriched
WBPaper00061651:AS_enriched
WBPaper00061651:AVA_enriched
WBPaper00061651:AVD_enriched
WBPaper00061651:AVL_enriched
WBPaper00061651:AVM_enriched
WBPaper00061651:AWA_enriched
WBPaper00061651:CEP_enriched
WBPaper00061651:DA9_enriched
WBPaper00061651:DA_enriched
WBPaper00061651:DB01_enriched
WBPaper00061651:DB_enriched
WBPaper00061651:HSN_enriched
WBPaper00061651:I4_enriched
WBPaper00061651:IL2_DV_enriched
WBPaper00061651:M2_enriched
WBPaper00061651:M5_enriched
WBPaper00061651:NSM_enriched
WBPaper00061651:PDB_enriched
WBPaper00061651:PDE_enriched
WBPaper00061651:PHB_enriched
WBPaper00061651:PLM_enriched
WBPaper00061651:PLN_enriched
WBPaper00061651:PVC_enriched
WBPaper00061651:RIM_enriched
WBPaper00061651:RME_DV_enriched
WBPaper00061651:RME_LR_enriched
WBPaper00061651:SAA_enriched
WBPaper00061651:SAB_enriched
WBPaper00061651:SMB_enriched
WBPaper00061651:SMD_enriched
WBPaper00061651:URA_enriched
WBPaper00061651:VA_enriched
WBPaper00061651:VC_4_5_enriched
WBPaper00062002:Day4-adult_secretome
WBPaper00062143:PQN-59_interacting
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062440:crh-1(n3315)_upregulated
WBPaper00062498:PPM-1.D_interacting
WBPaper00062554:MAGU-2_interacting
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064005:starvation_upregulated_N2_mRNA
WBPaper00064055:trl-1(cas1077)_upregulated_non-starved
WBPaper00064055:trl-1(cas1077)_upregulated_starved
WBPaper00064055:trl-1(cas1078)_upregulated_starved
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064156:lbp-3(overexpress)_upregulated
WBPaper00064201:SNA-1_interacting
WBPaper00064201:SNA-3_interacting
WBPaper00064257:UNG-1_interacting
WBPaper00064291:antimycin_upregulated
WBPaper00064315:met-1(bn200)_downregulated_PGCs
WBPaper00064637:cox-5B(RNAi)_upregulated
WBPaper00064716:paraquat_downregulated
WBPaper00064727:daf-2(e1370)_upregulated
WBPaper00064789:Day9_vs_Day1_upregulated_neuron
WBPaper00064933:E.coli-binding_secret_protein
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
WBPaper00065120:body-muscle-transcriptome
WBPaper00065149:lin-52(n771)_downregulated
WBPaper00065158:AFD_enriched
WBPaper00065258:anchor-cell_depleted
WBPaper00065373:sek-1(km4)_downregulated_cisplatin
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065623:143
WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977)
WBPaper00065749:Heat-Shock_upregulated_N2
WBPaper00065835:Day5_vs_Day1_downregulated
WBPaper00065835:Day11_vs_Day1_downregulated
WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11
WBPaper00065835:mtH2S-AP39-L1-treatment_upregulated_Day11
WBPaper00065841:4_1
WBPaper00065841:7_3
WBPaper00065841:38_1
WBPaper00065841:143_0
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066085:sin-3(syb2172)_upregulated
WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
cgc4386_cluster_1_6
cgc4489_group_24
WBPaper00025141:N2_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00031003:24hr_muscle_enriched
WBPaper00031003:hlh_1_enriched
WBPaper00031003:total_muscle_enriched
WBPaper00031060:2-deoxy-D-glucose_upregulated
WBPaper00031532:Larva_Pan_Neuronal_Depleted
WBPaper00032165:differentially_expressed_with_age_medoid_6
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00036123:Cadmium_regulated
WBPaper00036286:Pattern_C
WBPaper00037695:LD_DD_6-day
WBPaper00039835:ifg-1_upregulated
WBPaper00040426:CYD-1_CDK-4_downregulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
WBPaper00040821:Au-NP_regulated
WBPaper00040823:alg-1(gk214)_upregulated
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_old
WBPaper00040858:eQTL_regulated_reproductive
WBPaper00040985:AIN-2_asynchronous_muscle
WBPaper00041002:HF_3d_0.2mM_Up
WBPaper00041002:HF_3d_2.0mM_Up
WBPaper00041002:HF_11d_0.2mM_Up
WBPaper00041002:HF_11d_2.0mM_Up
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00042331:a-SWCNTs_downregulated
WBPaper00045263:0.1mM-paraquat_downregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00057098:SiO2-nanoparticles_downregulated
Interaction (231)
WBProcessWBbiopr:00000040
Map_infoMapIPosition27.9607Error0.002243
Well_ordered
PositiveInside_rearreDf3
eDf10
dxDf2
Positive_cloneF11C3Inferred_automaticallyFrom sequence, transcript, pseudogene data
SG25/36
Mapping_data2_point (22)
Multi_point (47)
Pos_neg_data (20)
Landmark_gene
Reference (599)
Remarkunc-54 posneg pcr data gives map conflict, spans deletion breakpoint ? jah 8.97
MethodGene