WormBase Tree Display for Gene: WBGene00006789

WBGene00006789 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 1
    Name: CGC_name: unc-54 Person_evidence: WBPerson261
      Sequence_name: F11C3.3
      Molecular_name: F11C3.3
        F11C3.3.1
        CE09349
      Other_name: myo-4
        CELE_F11C3.3 Accession_evidence: NDB BX284601
      Public_name: unc-54
    DB_info: Database: AceView gene 1P454
        WormQTL gene WBGene00006789
        WormFlux gene WBGene00006789
        NDB locus_tag CELE_F11C3.3
        Panther gene CAEEL|WormBase=WBGene00006789|UniProtKB=P02566
          family PTHR45615
        NCBI gene 259839
        RefSeq protein NM_061195.7
        SwissProt UniProtAcc P02566
        UniProt_GCRP UniProtAcc P02566
        OMIM gene 160710
            160720
            160740
            160741
            160760
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:42 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Allele (386)
    Legacy_information: Structural gene for major body wall myosin heavy chain. Reference null allele e190 : limp paralysed phenotype at all stages larvae can move slightly more than adults Egl; muscle ultrastructure very disorganized few thick filaments. ES3 ME0. NA (recessive) > 50 including e1108amber; e1301ts; e675sd and s291 (in frame internal deletion mutants with heavy chain fragment behavioral phenotype almost paralysed slight twitcher); also Tc1 insertion mutants; etc. Also unusual suppressor alleles (NA > 15) e.g. s74 : dominant suppressor of unc-22(s12) no other dominant phenotype recessive phenotype slow stiff normal muscle ultrastructure; alteration in S1 portion of protein. Also Class 3 (dominant) alleles reference allele e1152sd : severe rigid paralysis small; e1152/+ paralysed weaker phenotype. ES3 ME0. NA (dominant) > 10 : e1153 n489 etc.; resemble e1152 or more severe recessive lethal. Intragenic revertants have Class 1 phenotypes.
      See unc-54.
      See also e569, e576, e651, e675, e843, e903, e1008, e1009, e1021, e1092, e1108, e1115, e1152, e1153, e1157, e1168, e1201, e1213, e1219, e1223, e1257, e1258, e1273, e1274, e1300, e1301, e1311, e1315, e1328, e1360, e1419, e1420, n325, n326, n327, n489, n794, r274, r308, r322, r323, r327, r360, s74, s75, s76, s77, s78, s95, s291, s409, s411
      [C.elegansII] e190 : limp paralysed phenotype at all stages; larvae can move slightly more than adults; Egl; muscle ultrastructure very disorganized few thick filaments. ES3 ME0. OA>50 (recessive): e1108amb,e1301ts, e675sd and s291 (in frame internal deletion mutants, almost paralysed slight twitchers), etc. Also unusual suppressor alleles, OA>15: s74 (dominant suppressor of unc-22(s12), recessive slow, stiff; normal muscle ultrastructure) Also dominant antimorphic alleles, OA>10:e1152sd (severe rigid paralysis, small;e1152/+ paralysed weaker phenotype. ES3 ME0),r344 (recessive lethal, r344/+ severely paralysed), etc. Intragenic revertants have recessive paralysed phenotype. Some recessive alleles (r274, e1420 etc.) are dominant antimorphs in smg background. Cloned: encodes MHC B (MYO-4), major bodywall muscle myosin heavy chain. 6 kb message,1117 aa protein. Extensive molecular analysis. [Epstein et al. 1974; McLachlan and Karn 1982;Dibb et al. 1989; Bejsovec and Anderson 1990; TR; RW]
    Strain (1380)
    RNASeq_FPKM (74)
    GO_annotation (31)
    Ortholog (82)
    Paralog (21)
    Structured_description: Concise_description: unc-54 encodes a muscle myosin class II heavy chain (MHC B); UNC-54 is the major myosin heavy chain expressed in C. elegans and is required for locomotion and egg-laying; in vivo and in vitro, UNC-54 interacts with ITR-1, an IP3 receptor, and this interaction may provide a link between calcium signaling and the muscle cytoskeleton; UNC-54 is a thick filament component that is expressed in multiple muscle cell classes including body wall, intestinal, anal depressor, and sphincter muscles as well as sex-specific muscles that develop postembryonically. Paper_evidence: WBPaper00000232
            WBPaper00000647
            WBPaper00001014
            WBPaper00005299
            WBPaper00005940
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables actin filament binding activity and microfilament motor activity. A structural constituent of muscle. Involved in several processes, including egg-laying behavior; muscle contraction; and skeletal muscle myosin thick filament assembly. Located in A band and striated muscle myosin thick filament. Part of muscle myosin complex. Expressed in anal depressor muscle; body wall musculature; head; vulval muscle; and in male. Human ortholog(s) of this gene implicated in several diseases, including congenital heart disease (multiple); distal myopathy 1; and intrinsic cardiomyopathy (multiple). Is an ortholog of several human genes including MYH1 (myosin heavy chain 1); MYH2 (myosin heavy chain 2); and MYH3 (myosin heavy chain 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (30)
  Molecular_info: Corresponding_CDS: F11C3.3
    Corresponding_transcript: F11C3.3.1
    Other_sequence (386)
    Associated_feature (32)
  Experimental_info: RNAi_result (12)
    Expr_pattern: Chronogram1695
      Expr571
      Expr732
      Expr735
      Expr747
      Expr1145
      Expr3837
      Expr5737
      Expr11395
      Expr16474
      Expr1025092
      Expr1032860
      Expr1148311
      Expr2017887
      Expr2036023
    Drives_construct (151)
    Construct_product: WBCnstr00011688
      WBCnstr00011704
      WBCnstr00013869
      WBCnstr00015881
      WBCnstr00018819
      WBCnstr00034149
    Antibody (11)
    Microarray_results (22)
    Expression_cluster (308)
    Interaction (231)
    WBProcess: WBbiopr:00000040
  Map_info: Map: I Position: 27.9607 Error: 0.002243
    Well_ordered
    Positive: Inside_rearr: eDf3
        eDf10
        dxDf2
      Positive_clone: F11C3 Inferred_automatically: From sequence, transcript, pseudogene data
        SG25/36
    Mapping_data: 2_point (22)
      Multi_point (47)
      Pos_neg_data (20)
    Landmark_gene
  Reference: WBPaper00000031
    WBPaper00000125
    WBPaper00000126
    WBPaper00000143
    WBPaper00000159
    WBPaper00000231
    WBPaper00000232
    WBPaper00000233
    WBPaper00000345
    WBPaper00000347
    WBPaper00000348
    WBPaper00000436
    WBPaper00000438
    WBPaper00000439
    WBPaper00000442
    WBPaper00000461
    WBPaper00000471
    WBPaper00000485
    WBPaper00000509
    WBPaper00000515
    WBPaper00000536
    WBPaper00000561
    WBPaper00000570
    WBPaper00000571
    WBPaper00000575
    WBPaper00000579
    WBPaper00000608
    WBPaper00000612
    WBPaper00000613
    WBPaper00000635
    WBPaper00000636
    WBPaper00000643
    WBPaper00000644
    WBPaper00000647
    WBPaper00000651
    WBPaper00000691
    WBPaper00000695
    WBPaper00000708
    WBPaper00000710
    WBPaper00000732
    WBPaper00000738
    WBPaper00000741
    WBPaper00000744
    WBPaper00000754
    WBPaper00000755
    WBPaper00000768
    WBPaper00000779
    WBPaper00000785
    WBPaper00000801
    WBPaper00000804
    WBPaper00000805
    WBPaper00000876
    WBPaper00000896
    WBPaper00000897
    WBPaper00000907
    WBPaper00000914
    WBPaper00000915
    WBPaper00000924
    WBPaper00000947
    WBPaper00000983
    WBPaper00000985
    WBPaper00001009
    WBPaper00001014
    WBPaper00001021
    WBPaper00001026
    WBPaper00001027
    WBPaper00001051
    WBPaper00001065
    WBPaper00001090
    WBPaper00001091
    WBPaper00001124
    WBPaper00001155
    WBPaper00001192
    WBPaper00001194
    WBPaper00001202
    WBPaper00001224
    WBPaper00001230
    WBPaper00001234
    WBPaper00001238
    WBPaper00001245
    WBPaper00001296
    WBPaper00001329
    WBPaper00001340
    WBPaper00001344
    WBPaper00001352
    WBPaper00001358
    WBPaper00001394
    WBPaper00001470
    WBPaper00001476
    WBPaper00001525
    WBPaper00001527
    WBPaper00001558
    WBPaper00001570
    WBPaper00001649
    WBPaper00001662
    WBPaper00001664
    WBPaper00001672
    WBPaper00001692
    WBPaper00001709
    WBPaper00001747
    WBPaper00001748
    WBPaper00001751
    WBPaper00001763
    WBPaper00001772
    WBPaper00001807
    WBPaper00001812
    WBPaper00001813
    WBPaper00001820
    WBPaper00001832
    WBPaper00001849
    WBPaper00001895
    WBPaper00001912
    WBPaper00001939
    WBPaper00001956
    WBPaper00001975
    WBPaper00002006
    WBPaper00002044
    WBPaper00002070
    WBPaper00002289
    WBPaper00002292
    WBPaper00002305
    WBPaper00002339
    WBPaper00002354
    WBPaper00002357
    WBPaper00002401
    WBPaper00002411
    WBPaper00002476
    WBPaper00002644
    WBPaper00002748
    WBPaper00002774
    WBPaper00002802
    WBPaper00002890
    WBPaper00002925
    WBPaper00002956
    WBPaper00002965
    WBPaper00003005
    WBPaper00003118
    WBPaper00003210
    WBPaper00003309
    WBPaper00003339
    WBPaper00003389
    WBPaper00003644
    WBPaper00003787
    WBPaper00003794
    WBPaper00003822
    WBPaper00003883
    WBPaper00003891
    WBPaper00003937
    WBPaper00003943
    WBPaper00003977
    WBPaper00004117
    WBPaper00004128
    WBPaper00004145
    WBPaper00004202
    WBPaper00004325
    WBPaper00004346
    WBPaper00004356
    WBPaper00004378
    WBPaper00004431
    WBPaper00004883
    WBPaper00005171
    WBPaper00005193
    WBPaper00005218
    WBPaper00005245
    WBPaper00005299
    WBPaper00005557
    WBPaper00005723
    WBPaper00005809
    WBPaper00005816
    WBPaper00005940
    WBPaper00006119
    WBPaper00006309
    WBPaper00006428
    WBPaper00006443
    WBPaper00010146
    WBPaper00010425
    WBPaper00010799
    WBPaper00010806
    WBPaper00010934
    WBPaper00010948
    WBPaper00011015
    WBPaper00011020
    WBPaper00011237
    WBPaper00011594
    WBPaper00011620
    WBPaper00011706
    WBPaper00011870
    WBPaper00011967
    WBPaper00011969
    WBPaper00012270
    WBPaper00012278
    WBPaper00012387
    WBPaper00012408
    WBPaper00012595
    WBPaper00012617
    WBPaper00012674
    WBPaper00012714
    WBPaper00013454
    WBPaper00013500
    WBPaper00013649
    WBPaper00013705
    WBPaper00013765
    WBPaper00013771
    WBPaper00013850
    WBPaper00013851
    WBPaper00013852
    WBPaper00013892
    WBPaper00013893
    WBPaper00013894
    WBPaper00013896
    WBPaper00013926
    WBPaper00013929
    WBPaper00013960
    WBPaper00013961
    WBPaper00013964
    WBPaper00013992
    WBPaper00014004
    WBPaper00014054
    WBPaper00014087
    WBPaper00014091
    WBPaper00014092
    WBPaper00014094
    WBPaper00014096
    WBPaper00014099
    WBPaper00014109
    WBPaper00014136
    WBPaper00014145
    WBPaper00014149
    WBPaper00014150
    WBPaper00014170
    WBPaper00014191
    WBPaper00014309
    WBPaper00014311
    WBPaper00014346
    WBPaper00014355
    WBPaper00014357
    WBPaper00014365
    WBPaper00014366
    WBPaper00014367
    WBPaper00014375
    WBPaper00014377
    WBPaper00014382
    WBPaper00014396
    WBPaper00014397
    WBPaper00014415
    WBPaper00014426
    WBPaper00014435
    WBPaper00014445
    WBPaper00014451
    WBPaper00014452
    WBPaper00014466
    WBPaper00014494
    WBPaper00014499
    WBPaper00014500
    WBPaper00014518
    WBPaper00014538
    WBPaper00014552
    WBPaper00014557
    WBPaper00014578
    WBPaper00014601
    WBPaper00014616
    WBPaper00014677
    WBPaper00014681
    WBPaper00014682
    WBPaper00014711
    WBPaper00014715
    WBPaper00014719
    WBPaper00014731
    WBPaper00014739
    WBPaper00014752
    WBPaper00014753
    WBPaper00014788
    WBPaper00014793
    WBPaper00014823
    WBPaper00014857
    WBPaper00014886
    WBPaper00014896
    WBPaper00014940
    WBPaper00014941
    WBPaper00014950
    WBPaper00014990
    WBPaper00014991
    WBPaper00015043
    WBPaper00015047
    WBPaper00015053
    WBPaper00015054
    WBPaper00015071
    WBPaper00015088
    WBPaper00015122
    WBPaper00015145
    WBPaper00015180
    WBPaper00015214
    WBPaper00015216
    WBPaper00015219
    WBPaper00015326
    WBPaper00015332
    WBPaper00015350
    WBPaper00015383
    WBPaper00015391
    WBPaper00015418
    WBPaper00015451
    WBPaper00015469
    WBPaper00015486
    WBPaper00015495
    WBPaper00015529
    WBPaper00015544
    WBPaper00015546
    WBPaper00015606
    WBPaper00015632
    WBPaper00015640
    WBPaper00015674
    WBPaper00015702
    WBPaper00015709
    WBPaper00015711
    WBPaper00015718
    WBPaper00015760
    WBPaper00015792
    WBPaper00015829
    WBPaper00015883
    WBPaper00015884
    WBPaper00015885
    WBPaper00015895
    WBPaper00015915
    WBPaper00015926
    WBPaper00015951
    WBPaper00015952
    WBPaper00015954
    WBPaper00015955
    WBPaper00015987
    WBPaper00015996
    WBPaper00016042
    WBPaper00016058
    WBPaper00016074
    WBPaper00016080
    WBPaper00016081
    WBPaper00016151
    WBPaper00016153
    WBPaper00016190
    WBPaper00016229
    WBPaper00016236
    WBPaper00016238
    WBPaper00016245
    WBPaper00016278
    WBPaper00016344
    WBPaper00016353
    WBPaper00016356
    WBPaper00016376
    WBPaper00016378
    WBPaper00016379
    WBPaper00016380
    WBPaper00016388
    WBPaper00016417
    WBPaper00016428
    WBPaper00016434
    WBPaper00016444
    WBPaper00016445
    WBPaper00016454
    WBPaper00016464
    WBPaper00016495
    WBPaper00016510
    WBPaper00016526
    WBPaper00016527
    WBPaper00016528
    WBPaper00016549
    WBPaper00016550
    WBPaper00016567
    WBPaper00016578
    WBPaper00016892
    WBPaper00017197
    WBPaper00017298
    WBPaper00017305
    WBPaper00017325
    WBPaper00017403
    WBPaper00017408
    WBPaper00017410
    WBPaper00017496
    WBPaper00017524
    WBPaper00017652
    WBPaper00017656
    WBPaper00017698
    WBPaper00017705
    WBPaper00017854
    WBPaper00017955
    WBPaper00017981
    WBPaper00018167
    WBPaper00018219
    WBPaper00018320
    WBPaper00018451
    WBPaper00018824
    WBPaper00018868
    WBPaper00019069
    WBPaper00019420
    WBPaper00019529
    WBPaper00020789
    WBPaper00020795
    WBPaper00020841
    WBPaper00020900
    WBPaper00020970
    WBPaper00020980
    WBPaper00020987
    WBPaper00021035
    WBPaper00021045
    WBPaper00021053
    WBPaper00021072
    WBPaper00021090
    WBPaper00021091
    WBPaper00021098
    WBPaper00021110
    WBPaper00021650
    WBPaper00021665
    WBPaper00021686
    WBPaper00021696
    WBPaper00021733
    WBPaper00021766
    WBPaper00021790
    WBPaper00021923
    WBPaper00021973
    WBPaper00021975
    WBPaper00021994
    WBPaper00022008
    WBPaper00022012
    WBPaper00022023
    WBPaper00022034
    WBPaper00022088
    WBPaper00022185
    WBPaper00022202
    WBPaper00022205
    WBPaper00022286
    WBPaper00022382
    WBPaper00022422
    WBPaper00022504
    WBPaper00022600
    WBPaper00022859
    WBPaper00022919
    WBPaper00022920
    WBPaper00022936
    WBPaper00022952
    WBPaper00023126
    WBPaper00023319
    WBPaper00023436
    WBPaper00023685
    WBPaper00023712
    WBPaper00023723
    WBPaper00023797
    WBPaper00023849
    WBPaper00024165
    WBPaper00024293
    WBPaper00024436
    WBPaper00024779
    WBPaper00024798
    WBPaper00024961
    WBPaper00024994
    WBPaper00025227
    WBPaper00025247
    WBPaper00025301
    WBPaper00025353
    WBPaper00025420
    WBPaper00025797
    WBPaper00026106
    WBPaper00026267
    WBPaper00026305
    WBPaper00026758
    WBPaper00026761
    WBPaper00026899
    WBPaper00026911
    WBPaper00026926
    WBPaper00027093
    WBPaper00027210
    WBPaper00027253
    WBPaper00027255
    WBPaper00027309
    WBPaper00027312
    WBPaper00027319
    WBPaper00027590
    WBPaper00027669
    WBPaper00027706
    WBPaper00028374
    WBPaper00028442
    WBPaper00028564
    WBPaper00028612
    WBPaper00029017
    WBPaper00029020
    WBPaper00029065
    WBPaper00029138
    WBPaper00029196
    WBPaper00029301
    WBPaper00029345
    WBPaper00030446
    WBPaper00030472
    WBPaper00030977
    WBPaper00031097
    WBPaper00031777
    WBPaper00032009
    WBPaper00032220
    WBPaper00032784
    WBPaper00032907
    WBPaper00033013
    WBPaper00033152
    WBPaper00033208
    WBPaper00033342
    WBPaper00033492
    WBPaper00033576
    WBPaper00033973
    WBPaper00034395
    WBPaper00034513
    WBPaper00035140
    WBPaper00035357
    WBPaper00035398
    WBPaper00035423
    WBPaper00035589
    WBPaper00036532
    WBPaper00036573
    WBPaper00037063
    WBPaper00038060
    WBPaper00038491
    WBPaper00038534
    WBPaper00038954
    WBPaper00038979
    WBPaper00039458
    WBPaper00039462
    WBPaper00040286
    WBPaper00041022
    WBPaper00041079
    WBPaper00041836
    WBPaper00042475
    WBPaper00042592
    WBPaper00042773
    WBPaper00043836
    WBPaper00043864
    WBPaper00044758
    WBPaper00046489
    WBPaper00046661
    WBPaper00046899
    WBPaper00047354
    WBPaper00047628
    WBPaper00048000
    WBPaper00048337
    WBPaper00048456
    WBPaper00049226
    WBPaper00049692
    WBPaper00049828
    WBPaper00050564
    WBPaper00050689
    WBPaper00052825
    WBPaper00053522
    WBPaper00053843
    WBPaper00054726
    WBPaper00054775
    WBPaper00055090
    WBPaper00055156
    WBPaper00055895
    WBPaper00056554
    WBPaper00056617
    WBPaper00056812
    WBPaper00056909
    WBPaper00056939
    WBPaper00057217
    WBPaper00057371
    WBPaper00058059
    WBPaper00058096
    WBPaper00059048
    WBPaper00059117
    WBPaper00059169
    WBPaper00059588
    WBPaper00060420
    WBPaper00060754
    WBPaper00061547
    WBPaper00061698
    WBPaper00061750
    WBPaper00061786
    WBPaper00061805
    WBPaper00061911
    WBPaper00061917
    WBPaper00061940
    WBPaper00062080
    WBPaper00062518
    WBPaper00063880
    WBPaper00063939
    WBPaper00064078
    WBPaper00064181
    WBPaper00064293
    WBPaper00064339
    WBPaper00064630
    WBPaper00064634
    WBPaper00064685
    WBPaper00064733
    WBPaper00064835
    WBPaper00064910
    WBPaper00064917
    WBPaper00064926
    WBPaper00064942
    WBPaper00065114
    WBPaper00065300
    WBPaper00065314
    WBPaper00065741
    WBPaper00065757
    WBPaper00066037
    WBPaper00066105
    WBPaper00066286
  Remark: unc-54 posneg pcr data gives map conflict, spans deletion breakpoint ? jah 8.97
  Method: Gene