WormBase Tree Display for Gene: WBGene00006788

WBGene00006788 SMap: S_parent: Sequence: CHROMOSOME_II
  Identity: Version: 1
    Name: CGC_name: unc-53 Person_evidence: WBPerson261
      Sequence_name: F45E10.1
      Molecular_name (24)
      Other_name: CELE_F45E10.1 Accession_evidence: NDB BX284602
      Public_name: unc-53
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:42 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00143183
    Allele (424)
    Legacy_information: e404 : sluggish poor backing dumpyish somewhat Egl; males have abnormal bursal anatomy. ES2 ME0. NA4 (n152 n166 n569).
      See also e2432, e2499, n152, n166, n569
      [C.elegansII] e404 : sluggish, poor backing, dumpyish; somewhat Egl; multiple defects in neuronal outgrowth, branching; also defects in excretory canal extension, gonad arm growth; males have abnormal bursal anatomy. ES2 ME0. OA>5: n152, n166, n569 (synergizes with sem-5(n177) to give strong Sem migration defect),e2432, e2499, etc. Null phenotype uncertain; some lethality in strong alleles. Cloned: multiple transcripts (different 5' ends); one encodes 1528 aa protein, predicted to bind actin, ATP/GTP; may interact with SEM-5. Transgene overexpression leads to extension of growth cones along a-p axis. [Hedgecock et al. 1987; Hekimi and Kershaw 1993; UG]
    Strain: WBStrain00026706
      WBStrain00026870
      WBStrain00032757
      WBStrain00034470
      WBStrain00034483
      WBStrain00037045
      WBStrain00004162
      WBStrain00004572
      WBStrain00005655
    RNASeq_FPKM (74)
    GO_annotation (21)
    Ortholog: WBGene00053499 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00025929 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00158784 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00135997 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00102860 Pristionchus pacificus From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00224368 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g6509 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g1769 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g17096 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g1135 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g9104 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g16601 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g2472 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g2950 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g3757 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g11590 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00033.g1888 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_00981.g15216 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_11386.g23208 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-unc-53 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g16342 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00037.g2027 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_18819 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_005421 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g02553 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g17295 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_20337300 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrII_pilon.g5869 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00246889 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00267279 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00295310 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0263873 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-061207-13 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-021205-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-120215-84 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-120502-3 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-120920-3 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:15998 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:15989 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:15997 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:2183691 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:2183683 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:2183703 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:619778 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1306259 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1590261 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Structured_description: Concise_description: unc-53 encodes at least five large (~1200-1600 residue) proteins, orthologous to human NAV1, NAV2/RAINB1 (OMIM:607026), and NAV3, and homologous to Drosophila CG10662; UNC-53 proteins are required for anteroposterior guidance of migrating cells, axons, and excretory cell canals; unc-53 mutations affect egg laying, backward locomotion, body size, and male mating; UNC-53 proteins vary in their N-terminal regions but share common C-terminal sequences with a AAA-ATPase domain; the UNC-53 N-terminus physically interacts with ABI-1, suggesting that UNC-53 may function as a scaffold to link the ARP2/3 complex to ABI-1; UNC-53 also interacts both physically and genetically with SEM-5; unc-53 is expressed in those cells requiring it, suggesting that its function is cell-autonomous; overexpression of unc-53 induces excess cellular outgrowth. Paper_evidence (11)
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 13 Nov 2012 00:00:00
      Automated_description: Predicted to enable actin filament binding activity. Involved in several processes, including backward locomotion; positive regulation of locomotion; and reproductive behavior. Located in cytoplasm. Expressed in several structures, including excretory cell; hermaphrodite distal tip cell; neurons; non-striated muscle; and socket cell. Is an ortholog of human NAV1 (neuron navigator 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:2559 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:15998)
  Molecular_info: Corresponding_CDS: F45E10.1a
      F45E10.1b
      F45E10.1c
      F45E10.1d
      F45E10.1e
      F45E10.1f
      F45E10.1g
      F45E10.1h
    Corresponding_CDS_history: F45E10.1:wp82
    Corresponding_transcript: F45E10.1a.1
      F45E10.1b.1
      F45E10.1c.1
      F45E10.1d.1
      F45E10.1e.1
      F45E10.1f.1
      F45E10.1g.1
      F45E10.1h.1
    Other_sequence (27)
    Associated_feature (66)
  Experimental_info: RNAi_result (14)
    Expr_pattern (12)
    Drives_construct (25)
    Construct_product: WBCnstr00009444
      WBCnstr00010519
      WBCnstr00010520
      WBCnstr00010521
      WBCnstr00034150
    Antibody: WBAntibody00001615
      WBAntibody00001625
    Microarray_results (40)
    Expression_cluster (219)
    Interaction (103)
    Anatomy_function: WBbtf0113
      WBbtf0114
      WBbtf0118
      WBbtf0119
  Map_info: Map: II Position: 3.16568 Error: 0.005694
    Well_ordered
    Positive: Positive_clone: F45E10 Inferred_automatically: From sequence, transcript, pseudogene data
        T28D2
    Mapping_data: 2_point: 43
      Multi_point (11)
      Pos_neg_data: 2145
        2146
        2159
        2163
        4533
        4534
        4535
        4536
        4539
        10562
  Reference (99)
  Method: Gene