WormBase Tree Display for Gene: WBGene00006784
expand all nodes | collapse all nodes | view schema
| WBGene00006784 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | T21C12 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-49 | Person_evidence | WBPerson261 | |||||
| Sequence_name | T21C12.1 | ||||||||
| Molecular_name (40) | |||||||||
| Other_name | unc-49A | Accession_evidence | EMBL | AF151640 | |||||
| unc-49B | Accession_evidence | EMBL | AF151641 | ||||||
| unc-49C | Accession_evidence | EMBL | AF151644 | ||||||
| CELE_T21C12.1 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | unc-49 | ||||||||
| DB_info | Database | AceView | gene | 3L621 | |||||
| WormQTL | gene | WBGene00006784 | |||||||
| WormFlux | gene | WBGene00006784 | |||||||
| NDB | locus_tag | CELE_T21C12.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006784|UniProtKB=G5ECD3 | |||||||
| family | PTHR18945 | ||||||||
| NCBI | gene | 176472 | |||||||
| RefSeq | protein (13) | ||||||||
| TrEMBL | UniProtAcc (13) | ||||||||
| UniProt_GCRP | UniProtAcc | G5ECD3 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143164 | ||||||||
| Allele (220) | |||||||||
| Legacy_information | e382 : shrinker contracts both dorsally and ventrally when prodded slow poor backing slightly small. ES3 ME2. NA6 (e407 e468). | ||||||||
| See also e641, n1324 | |||||||||
| [C.elegansII] e382 : shrinker, contracts both dorsally and ventrally when prodded; slow; poor backing, slightly small. Probable defect in inhibitory GABA receptor function. ES3 ME2. OA>5: e407, e468, e929, n1324 etc. Cloned: encodes predicted GABA-A receptor. In probable operon with two other GABA receptor subunits. [Brenner 1974; McIntire et al. 1993; EG; MT] | |||||||||
| Strain (14) | |||||||||
| Component_of_genotype | WBGenotype00000119 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (28) | |||||||||
| Ortholog (37) | |||||||||
| Paralog (100) | |||||||||
| Structured_description | Concise_description | unc-49 encodes multiple subunits of a heteromeric GABA receptor; unc-49 activity is required for postsynaptic GABA responsiveness and thus for normal regulation of locomotion; UNC-49::GFP reporter fusions for at least two isoforms are expressed in dorsal and ventral head and body wall muscles, with isoform-specific expression also seen in the sphincter muscle; UNC-49::GFP subcellular localization is most prominent at neuromuscular junctions; in Xenopus oocytes and mammalian tissue culture cells, two UNC-49 subunits, UNC-49B and UNC-49C, are able to form a functional heteromeric GABA receptor. | Paper_evidence | WBPaper00003576 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 24 Aug 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to contribute to chloride channel activity. Involved in gamma-aminobutyric acid signaling pathway; locomotory behavior; and regulation of backward locomotion. Located in neuromuscular junction and postsynaptic membrane. Expressed in AVA; anal sphincter muscle; body wall musculature; and somatic nervous system. Used to study epilepsy. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00060194 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 18 May 2022 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00001202 | ||||||||
| WBDOannot00001203 | |||||||||
| Molecular_info | Corresponding_CDS (13) | ||||||||
| Corresponding_CDS_history | T21C12.1a:wp227 | ||||||||
| T21C12.1a:wp239 | |||||||||
| T21C12.1g:wp275 | |||||||||
| Corresponding_transcript (14) | |||||||||
| Other_sequence (51) | |||||||||
| Associated_feature (25) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00090257 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00053708 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089728 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066348 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027895 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00000954 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090099 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00018961 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089939 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00006214 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1283 | ||||||||
| Expr15907 | |||||||||
| Expr1027570 | |||||||||
| Expr1032855 | |||||||||
| Expr1157259 | |||||||||
| Expr1200291 | |||||||||
| Expr2017881 | |||||||||
| Expr2036017 | |||||||||
| Marker2 | |||||||||
| Marker19 | |||||||||
| Drives_construct | WBCnstr00001626 | ||||||||
| WBCnstr00001627 | |||||||||
| WBCnstr00006881 | |||||||||
| WBCnstr00010191 | |||||||||
| WBCnstr00019381 | |||||||||
| WBCnstr00020581 | |||||||||
| WBCnstr00034153 | |||||||||
| WBCnstr00042588 | |||||||||
| Construct_product | WBCnstr00001627 | ||||||||
| WBCnstr00006881 | |||||||||
| WBCnstr00016180 | |||||||||
| WBCnstr00019381 | |||||||||
| WBCnstr00020010 | |||||||||
| WBCnstr00020581 | |||||||||
| WBCnstr00021428 | |||||||||
| WBCnstr00034153 | |||||||||
| Antibody | WBAntibody00000613 | ||||||||
| WBAntibody00001987 | |||||||||
| Microarray_results (88) | |||||||||
| Expression_cluster (187) | |||||||||
| Interaction (31) | |||||||||
| WBProcess | WBbiopr:00000010 | ||||||||
| Map_info | Map | III | Position | 3.35021 | Error | 0.089636 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDf40 | |||||||
| mT1 | |||||||||
| Positive_clone | T21C12 | Person_evidence | WBPerson39 | ||||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | 2_point | 73 | |||||||
| 86 | |||||||||
| 589 | |||||||||
| 3249 | |||||||||
| Multi_point | 60 | ||||||||
| 81 | |||||||||
| 85 | |||||||||
| 86 | |||||||||
| 87 | |||||||||
| 88 | |||||||||
| 89 | |||||||||
| 211 | |||||||||
| 212 | |||||||||
| 213 | |||||||||
| 214 | |||||||||
| 215 | |||||||||
| 216 | |||||||||
| 300 | |||||||||
| 301 | |||||||||
| 469 | |||||||||
| 471 | |||||||||
| 472 | |||||||||
| 473 | |||||||||
| 474 | |||||||||
| 476 | |||||||||
| 482 | |||||||||
| 483 | |||||||||
| 489 | |||||||||
| 493 | |||||||||
| 494 | |||||||||
| 497 | |||||||||
| 500 | |||||||||
| 501 | |||||||||
| 503 | |||||||||
| 504 | |||||||||
| 507 | |||||||||
| 514 | |||||||||
| 562 | |||||||||
| 563 | |||||||||
| 1246 | |||||||||
| 1253 | |||||||||
| 1356 | |||||||||
| 1811 | |||||||||
| 1814 | |||||||||
| 1819 | |||||||||
| 2196 | |||||||||
| 2202 | |||||||||
| 2203 | |||||||||
| 2204 | |||||||||
| 2205 | |||||||||
| 3217 | |||||||||
| 3223 | |||||||||
| 3224 | |||||||||
| 3235 | |||||||||
| 3237 | |||||||||
| 4097 | |||||||||
| 5025 | |||||||||
| 5626 | |||||||||
| 5710 | |||||||||
| Pos_neg_data | 3242 | ||||||||
| 3250 | |||||||||
| 3251 | |||||||||
| Reference (138) | |||||||||
| Remark | Sequence connection from [Bamber BA] | ||||||||
| Method | Gene |
