WormBase Tree Display for Gene: WBGene00006770

WBGene00006770 SMap: S_parent: Sequence: Y50D4C
  Identity: Version: 2
    Name: CGC_name: unc-34 Person_evidence: WBPerson261
      Sequence_name: Y50D4C.1
      Molecular_name (21)
      Other_name: CELE_Y50D4C.1 Accession_evidence: NDB BX284605
      Public_name: unc-34
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:42 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 02 Mar 2018 11:09:16 WBPerson4025 Event: Split_into: WBGene00303091
      Split_into: WBGene00303091
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00143110
    Allele: WBVar00143110 Inferred_automatically: From strain object: CB315
          From strain object: JK1219
          From strain object: QP218
      WBVar00143303 Inferred_automatically: From strain object: CB566
          From strain object: KX10
          From strain object: MT4446
          From strain object: MT6185
      WBVar00146339
      WBVar00145246
      WBVar00143297
      WBVar00146340
      WBVar00241734
      WBVar00143629
      WBVar01774503
      WBVar01985293
      WBVar01274753
      WBVar01985294
      WBVar01985295
      WBVar01274754
      WBVar01985296
      WBVar02004493
      WBVar01985297
      WBVar01985298
      WBVar02099812
      WBVar01499528
      WBVar01689491
      WBVar00303526
      WBVar01689492
      WBVar01689493
      WBVar01689494
      WBVar01689495
      WBVar01689496
      WBVar00983268
      WBVar01499167
      WBVar01689497
      WBVar01689498
      WBVar00983269
      WBVar01689499
      WBVar00983270
      WBVar01689500
      WBVar00983271
      WBVar00983272
      WBVar00983273
      WBVar00983274
      WBVar00983275
      WBVar00983276
      WBVar00983277
      WBVar00983278
      WBVar00983279
      WBVar00983280
      WBVar00983281
      WBVar00983282
      WBVar00271393
      WBVar00983283
      WBVar00983284
      WBVar00983285
      WBVar00983286
      WBVar00983287
      WBVar00983288
      WBVar01499740
      WBVar00983289
      WBVar00983290
      WBVar00983291
      WBVar00983292
      WBVar00983293
      WBVar00983294
      WBVar00983295
      WBVar00983296
      WBVar00983297
      WBVar00983298
      WBVar00983299
      WBVar00983300
      WBVar00448952
      WBVar00983301
      WBVar00448953
      WBVar00983302
      WBVar00448954
      WBVar00983303
      WBVar00983304
      WBVar01860492
      WBVar00448955
      WBVar00448956
      WBVar00983305
      WBVar00983306
      WBVar00448957
      WBVar00983307
      WBVar00448958
      WBVar00263940
      WBVar00448959
      WBVar00983308
      WBVar00448960
      WBVar00983309
      WBVar02008765
      WBVar00448961
      WBVar00983310
      WBVar00983311
      WBVar00088504
      WBVar02008766
      WBVar00448962
      WBVar00983312
      WBVar00306953
      WBVar00448963
      WBVar02008767
      WBVar00318858
      WBVar00983313
      WBVar00306954
      WBVar00448964
      WBVar00448965
      WBVar00983314
      WBVar00448966
      WBVar00983315
      WBVar00448967
      WBVar00983316
      WBVar00448968
      WBVar02043215
      WBVar00983317
      WBVar02082759
      WBVar01498849
      WBVar00448969
      WBVar00983318
      WBVar00983319
      WBVar00448970
      WBVar02082760
      WBVar01498850
      WBVar00983320
      WBVar00448971
      WBVar01848328
      WBVar00983321
      WBVar00448972
      WBVar00983322
      WBVar00448973
      WBVar01661148
      WBVar02119568
      WBVar00983323
      WBVar00448974
      WBVar00448975
      WBVar01661149
      WBVar01499775
      WBVar00983324
      WBVar00448976
      WBVar00983325
      WBVar01737592
      WBVar00448977
      WBVar00983326
      WBVar01737593
      WBVar00983327
      WBVar00448978
      WBVar00448979
      WBVar00983328
      WBVar00448980
      WBVar00983329
      WBVar00983330
      WBVar00448981
      WBVar00983331
      WBVar00600917
      WBVar00983332
      WBVar00580616
      WBVar01833685
      WBVar00983333
      WBVar00580621
      WBVar00580622
      WBVar00983334
      WBVar00580623
      WBVar00983335
      WBVar00983336
      WBVar00580626
      WBVar00983337
      WBVar00983338
      WBVar02051785
      WBVar02051786
      WBVar00983339
      WBVar02051787
      WBVar00983340
      WBVar00983341
      WBVar00983342
      WBVar00983343
      WBVar01483417
      WBVar02135638
      WBVar01483418
      WBVar00983344
      WBVar02135639
      WBVar00983345
      WBVar01483419
      WBVar02135640
      WBVar02031655
      WBVar01483420
      WBVar00983346
      WBVar02031656
      WBVar00983347
      WBVar02031657
      WBVar00983348
      WBVar00983349
      WBVar00983350
      WBVar00983351
      WBVar00983352
      WBVar00983353
      WBVar00983354
      WBVar00983355
      WBVar00983356
      WBVar00322569
      WBVar00983357
      WBVar00983358
      WBVar01584424
      WBVar01584425
      WBVar00983359
      WBVar01584426
      WBVar00983360
      WBVar00983361
      WBVar01584427
      WBVar00983362
      WBVar01584428
      WBVar01584429
      WBVar01584430
      WBVar01584431
      WBVar01584432
      WBVar01584433
      WBVar01492458
      WBVar01584434
      WBVar01584435
      WBVar01584436
      WBVar01584437
      WBVar01609921
      WBVar01584438
      WBVar01609922
      WBVar01410629
      WBVar01609923
      WBVar01924457
      WBVar01609924
      WBVar00146336
      WBVar01609925
      WBVar01924458
      WBVar01609926
      WBVar01924459
      WBVar01609927
      WBVar02107291
      WBVar01924460
      WBVar02092755
      WBVar01609928
      WBVar01924461
      WBVar01609929
      WBVar01924462
      WBVar01609930
      WBVar01924463
      WBVar01924464
      WBVar01924465
      WBVar01924466
      WBVar01924467
      WBVar01924468
      WBVar01924469
      WBVar01924470
      WBVar01924471
      WBVar01924472
      WBVar01924473
      WBVar01924474
      WBVar01924475
      WBVar00254270
      WBVar01924476
      WBVar01901014
      WBVar00264026
      WBVar01924477
      WBVar02077280
      WBVar01924478
      WBVar01924479
      WBVar01924480
      WBVar01924481
      WBVar01970735
      WBVar01970736
      WBVar01521073
      WBVar01924482
      WBVar01521074
      WBVar01970737
      WBVar01818931
      WBVar01521075
      WBVar01970738
      WBVar01970739
      WBVar01521076
      WBVar01521077
      WBVar01970740
      WBVar01521078
      WBVar01970741
      WBVar00202246
      WBVar01521079
      WBVar00202247
      WBVar01970742
      WBVar00202248
      WBVar01970743
      WBVar01521080
      WBVar00202249
      WBVar01521081
      WBVar01970744
      WBVar00202250
      WBVar01521082
      WBVar01970745
      WBVar00202251
      WBVar01521083
      WBVar00202252
      WBVar01521084
      WBVar01521085
      WBVar00202253
      WBVar01521086
      WBVar02090397
      WBVar00202254
      WBVar00202255
      WBVar01521087
      WBVar01499496
      WBVar01521088
      WBVar00202256
      WBVar01521089
      WBVar00202257
      WBVar00202258
      WBVar01521090
      WBVar01521091
      WBVar00202259
      WBVar00202260
      WBVar01521092
      WBVar01521093
      WBVar00202261
      WBVar01521094
      WBVar00202262
      WBVar01521095
      WBVar00202263
      WBVar01521096
      WBVar00202264
      WBVar00320706
      WBVar01521097
      WBVar00202265
      WBVar01521098
      WBVar00202266
      WBVar01521099
      WBVar00202267
      WBVar02022999
      WBVar01521100
      WBVar00202268
      WBVar01774497
      WBVar01457864
      WBVar01521101
      WBVar00202269
      WBVar01674160
      WBVar01457865
      WBVar01521102
      WBVar01774498
      WBVar00202270
      WBVar01457866
      WBVar01774499
      WBVar01521103
      WBVar01457867
      WBVar02111394
      WBVar01521104
      WBVar01774500
      WBVar01774501
      WBVar01521105
      WBVar01500066
      WBVar01457868
      WBVar01774502
    Legacy_information: e315ts : at 20x fairly severe coiler somewhat active grows well; male has crumpled copulatory spicules; variable defects in VD and DD commissures; at 15x moves much better. ES3 (20x) ME0. NA3 (e566 e951pdi : non-ts alleles coilers at all temperatures; e566 strongest allele).
      See also s138
      [C.elegansII] e315ts : at 20C fairly severe coiler, somewhat active, grows well; male has crumpled copulatory spicules; variable defects in VD and DD commissures; At 15C moves much better. Low penetrance withered tail phenotype (CAN cell defect),and excretory cell abnormalities.ES3 (20C) ME0. OA>5: e566, (strongest allele,non-ts, coils at all temperatures; defects in axonal elongation and fasciculation), e951pdi, s138gri, etc. [Brenner 1974; McIntire et al. 1992; CX; NG; NW; MT]
    Strain: WBStrain00022543
      WBStrain00024076
      WBStrain00024143
      WBStrain00027135
      WBStrain00027253
      WBStrain00031248
      WBStrain00004147
      WBStrain00004181
      WBStrain00051845
      WBStrain00053139
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog (45)
    Structured_description: Concise_description: unc-34 encodes an EVH1 domain-containing protein that is the sole C. elegans Enabled/VASP homolog; during development, unc-34 activity is required for proper cell migration and axon guidance and for normal locomotion and posterior body morphology; in regulating axon guidance, genetic analyses suggest that unc-34 likely functions downstream of slt-1/Slit and sax-3/Robo as well as unc-6/Netrin and unc-40/DCC, but in parallel to Rac GTPases and mig-15/NIK; in addition, UNC-34 binds MIG-10/RIAM/Lamellipodin in vitro, suggesting that UNC-34 functions as a link between external guidance cues and axon outgrowth; a functional UNC-34::GFP fusion protein localizes to the tips of filopodia in both dorsal and ventral domains of the HSN neuron. Paper_evidence: WBPaper00005544
            WBPaper00005719
            WBPaper00024256
            WBPaper00026842
            WBPaper00027144
            WBPaper00027185
            WBPaper00027328
          Curator_confirmed: WBPerson1843
          Date_last_updated: 27 Feb 2007 00:00:00
      Automated_description: Enables signaling receptor binding activity. Involved in axon development; gonad morphogenesis; and positive regulation of locomotion. Located in several cellular components, including cell junction; cell leading edge; and filopodium tip. Expressed in epithelial cell. Used to study tauopathy. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Is an ortholog of human ENAH (ENAH actin regulator) and EVL (Enah/Vasp-like). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:680 Homo sapiens Paper_evidence: WBPaper00030773
          Curator_confirmed: WBPerson324
          Date_last_updated: 15 Oct 2018 00:00:00
    Potential_model: DOID:684 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18271)
  Models_disease_asserted: WBDOannot00000620
  Molecular_info: Corresponding_CDS: Y50D4C.1a
      Y50D4C.1b
      Y50D4C.1c
      Y50D4C.1d
      Y50D4C.1e
      Y50D4C.1f
      Y50D4C.1g
    Corresponding_CDS_history: Y50D4C.1:wp90
      Y50D4C.1a:wp196
      Y50D4C.1h:wp264
    Corresponding_transcript: Y50D4C.1a.1
      Y50D4C.1b.1
      Y50D4C.1c.1
      Y50D4C.1d.1
      Y50D4C.1e.1
      Y50D4C.1f.1
      Y50D4C.1g.1
    Other_sequence: HSC01560_1
      CBC07398_1
      EV852287.1
      MH02808
      Oden_isotig19132
      DVC02358_1
      JI224248.1
      FG351923.1
      Dviv_isotig13420
      TV01239
      MC00096
      EV850166.1
      Dviv_isotig13418
      ACC12315_1
      Acan_isotig16825
      HG10586
      EY463349.1
      FC542283.1
      Acan_isotig08882
      HGC08995_1
      HS01188
    Associated_feature (12)
  Experimental_info (11)
  Map_info: Map: V Position: -19.8783 Error: 0.017009
    Well_ordered
    Positive: Inside_rearr: yDp1
      Positive_clone: Y50D4C Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 124
        586
        1731
        3138
        3145
        6113
      Multi_point (18)
      Pos_neg_data: 3089
        3095
        3104
        3396
        3146
        3147
        5194
        3258
  Reference (145)
  Method: Gene