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WormBase Tree Display for Gene: WBGene00006770

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WBGene00006770	SMap	S_parent	Sequence	Y50D4C
	Identity	Version	2
		Name	CGC_name	unc-34	Person_evidence	WBPerson261
			Sequence_name	Y50D4C.1
			Molecular_name	Y50D4C.1a
				Y50D4C.1a.1
				CE43197
				Y50D4C.1b
				CE33232
				Y50D4C.1c
				CE50871
				Y50D4C.1d
				CE50774
				Y50D4C.1e
				CE50842
				Y50D4C.1f
				CE50860
				Y50D4C.1g
				CE50825
				Y50D4C.1b.1
				Y50D4C.1c.1
				Y50D4C.1d.1
				Y50D4C.1e.1
				Y50D4C.1f.1
				Y50D4C.1g.1
			Other_name	CELE_Y50D4C.1	Accession_evidence	NDB	BX284605
			Public_name	unc-34
		DB_info	Database (11)
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:42	WBPerson1971	Event	Imported	Initial conversion from geneace
				2	02 Mar 2018 11:09:16	WBPerson4025	Event	Split_into	WBGene00303091
			Split_into	WBGene00303091
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	unc
		Reference_allele	WBVar00143110
		Allele (349)
		Legacy_information	e315ts : at 20x fairly severe coiler somewhat active grows well; male has crumpled copulatory spicules; variable defects in VD and DD commissures; at 15x moves much better. ES3 (20x) ME0. NA3 (e566 e951pdi : non-ts alleles coilers at all temperatures; e566 strongest allele).
			See also s138
			[C.elegansII] e315ts : at 20C fairly severe coiler, somewhat active, grows well; male has crumpled copulatory spicules; variable defects in VD and DD commissures; At 15C moves much better. Low penetrance withered tail phenotype (CAN cell defect),and excretory cell abnormalities.ES3 (20C) ME0. OA>5: e566, (strongest allele,non-ts, coils at all temperatures; defects in axonal elongation and fasciculation), e951pdi, s138gri, etc. [Brenner 1974; McIntire et al. 1992; CX; NG; NW; MT]
		Strain	WBStrain00022543
			WBStrain00024076
			WBStrain00024143
			WBStrain00027135
			WBStrain00027253
			WBStrain00031248
			WBStrain00004147
			WBStrain00004181
			WBStrain00051845
			WBStrain00053139
		RNASeq_FPKM (74)
		GO_annotation (14)
		Ortholog	WBGene00062141	Caenorhabditis remanei	From_analysis	TreeFam
						Inparanoid_8
						WormBase-Compara
			WBGene00037397	Caenorhabditis briggsae	From_analysis	OrthoMCL
						Inparanoid_8
						WormBase-Compara
			WBGene00146192	Caenorhabditis brenneri	From_analysis	TreeFam
						Inparanoid_8
						WormBase-Compara
			WBGene00164861	Caenorhabditis brenneri	From_analysis	TreeFam
						Inparanoid_8
						WormBase-Compara
			WBGene00128959	Caenorhabditis japonica	From_analysis	TreeFam
						Inparanoid_8
						WormBase-Compara
			WBGene00230805	Brugia malayi	From_analysis	WormBase-Compara
			CBOVI.g1230	Caenorhabditis bovis	From_analysis	WormBase-Compara
			CSP21.g3850	Caenorhabditis parvicauda	From_analysis	WormBase-Compara
			CSP26.g18556	Caenorhabditis zanzibari	From_analysis	WormBase-Compara
			CSP28.g21961	Caenorhabditis panamensis	From_analysis	WormBase-Compara
			CSP29.g10575	Caenorhabditis becei	From_analysis	WormBase-Compara
			CSP31.g23677	Caenorhabditis uteleia	From_analysis	WormBase-Compara
			CSP32.g10848	Caenorhabditis sulstoni	From_analysis	WormBase-Compara
			CSP38.g21517	Caenorhabditis quiockensis	From_analysis	WormBase-Compara
			CSP39.g14482	Caenorhabditis waitukubuli	From_analysis	WormBase-Compara
			CSP40.g2737	Caenorhabditis tribulationis	From_analysis	WormBase-Compara
			Cni-unc-34	Caenorhabditis nigoni	From_analysis	WormBase-Compara
			Csp11.Scaffold629.g13099	Caenorhabditis tropicalis	From_analysis	WormBase-Compara
			Csp5_scaffold_00850.g16080	Caenorhabditis sinica	From_analysis	WormBase-Compara
			FL83_15264	Caenorhabditis latens	From_analysis	WormBase-Compara
			GCK72_019115	Caenorhabditis remanei	From_analysis	WormBase-Compara
			OTIPU.nOt.2.0.1.g00851	Oscheius tipulae	From_analysis	WormBase-Compara
			Pan_g7716	Panagrellus redivivus	From_analysis	WormBase-Compara
			Sp34_50001200	Caenorhabditis inopinata	From_analysis	WormBase-Compara
			chrV_pilon.g13162	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00243953	Onchocerca volvulus	From_analysis	WormBase-Compara
			WBGene00099054	Pristionchus pacificus	From_analysis	WormBase-Compara
			WBGene00263896	Strongyloides ratti	From_analysis	WormBase-Compara
			WBGene00296670	Trichuris muris	From_analysis	WormBase-Compara
			WBGene00302007	Trichuris muris	From_analysis	WormBase-Compara
			FB:FBgn0000578	Drosophila melanogaster	From_analysis	EnsEMBL-Compara
						OrthoFinder
						OrthoInspector
						Panther
			ZFIN:ZDB-GENE-000607-65	Danio rerio	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						Panther
						SonicParanoid
			ZFIN:ZDB-GENE-040426-1804	Danio rerio	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OrthoFinder
						Panther
						SonicParanoid
			ZFIN:ZDB-GENE-010323-11	Danio rerio	From_analysis	EnsEMBL-Compara
						Inparanoid
						OrthoFinder
						Panther
						SonicParanoid
			ZFIN:ZDB-GENE-030131-7118	Danio rerio	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						Panther
						SonicParanoid
			ZFIN:ZDB-GENE-070424-68	Danio rerio	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						SonicParanoid
			HGNC:12652	Homo sapiens	From_analysis	EnsEMBL-Compara
						Hieranoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						SonicParanoid
			HGNC:20234	Homo sapiens	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						SonicParanoid
			HGNC:18271	Homo sapiens	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						SonicParanoid
			MGI:108360	Mus musculus	From_analysis	EnsEMBL-Compara
						Inparanoid
						OrthoFinder
						Panther
			MGI:1194884	Mus musculus	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						Panther
						SonicParanoid
			MGI:109268	Mus musculus	From_analysis	EnsEMBL-Compara
						Hieranoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						SonicParanoid
			RGD:621150	Rattus norvegicus	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						SonicParanoid
			RGD:1307666	Rattus norvegicus	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						SonicParanoid
			RGD:1311542	Rattus norvegicus	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						SonicParanoid
		Structured_description	Concise_description	unc-34 encodes an EVH1 domain-containing protein that is the sole C. elegans Enabled/VASP homolog; during development, unc-34 activity is required for proper cell migration and axon guidance and for normal locomotion and posterior body morphology; in regulating axon guidance, genetic analyses suggest that unc-34 likely functions downstream of slt-1/Slit and sax-3/Robo as well as unc-6/Netrin and unc-40/DCC, but in parallel to Rac GTPases and mig-15/NIK; in addition, UNC-34 binds MIG-10/RIAM/Lamellipodin in vitro, suggesting that UNC-34 functions as a link between external guidance cues and axon outgrowth; a functional UNC-34::GFP fusion protein localizes to the tips of filopodia in both dorsal and ventral domains of the HSN neuron.	Paper_evidence	WBPaper00005544
						WBPaper00005719
						WBPaper00024256
						WBPaper00026842
						WBPaper00027144
						WBPaper00027185
						WBPaper00027328
					Curator_confirmed	WBPerson1843
					Date_last_updated	27 Feb 2007 00:00:00
			Automated_description	Enables signaling receptor binding activity. Involved in axon development; gonad morphogenesis; and positive regulation of locomotion. Located in several cellular components, including cell junction; cell leading edge; and filopodium tip. Expressed in epithelial cell. Used to study tauopathy. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Is an ortholog of human ENAH (ENAH actin regulator) and EVL (Enah/Vasp-like).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Disease_info	Experimental_model	DOID:680	Homo sapiens	Paper_evidence	WBPaper00030773
					Curator_confirmed	WBPerson324
					Date_last_updated	15 Oct 2018 00:00:00
		Potential_model	DOID:684	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:18271)
	Models_disease_asserted	WBDOannot00000620
	Molecular_info	Corresponding_CDS	Y50D4C.1a
			Y50D4C.1b
			Y50D4C.1c
			Y50D4C.1d
			Y50D4C.1e
			Y50D4C.1f
			Y50D4C.1g
		Corresponding_CDS_history	Y50D4C.1:wp90
			Y50D4C.1a:wp196
			Y50D4C.1h:wp264
		Corresponding_transcript	Y50D4C.1a.1
			Y50D4C.1b.1
			Y50D4C.1c.1
			Y50D4C.1d.1
			Y50D4C.1e.1
			Y50D4C.1f.1
			Y50D4C.1g.1
		Other_sequence (21)
		Associated_feature (12)
	Experimental_info (11)
	Map_info	Map	V	Position	-19.8783	Error	0.017009
		Well_ordered
		Positive	Inside_rearr	yDp1
			Positive_clone	Y50D4C	Inferred_automatically	From sequence, transcript, pseudogene data
		Mapping_data	2_point	124
				586
				1731
				3138
				3145
				6113
			Multi_point (18)
			Pos_neg_data	3089
				3095
				3104
				3396
				3146
				3147
				5194
				3258
	Reference (145)
	Method	Gene