WormBase Tree Display for Gene: WBGene00006766
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| WBGene00006766 | SMap | S_parent | Sequence | B0564 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-30 | Person_evidence | WBPerson261 | |||||
| Sequence_name | B0564.10 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | CELE_B0564.10 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | unc-30 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143025 | ||||||||
| Allele (113) | |||||||||
| Legacy_information | e191 : shrinker contracts both dorsally and ventrally when touched; slow good forward movement but poor backing rather small; VD and DD motoneuron axons are displaced and fail to stain with anti-GABA antibodies. ES3 ME2 NA8 (e165 e318 etc.). | ||||||||
| See also e845, e2384, e2505 | |||||||||
| [C.elegansII] e191 : shrinker, contracts both dorsally and ventrally when touched; slow good forward movement but poor backing, rather small; VD and DD motoneuron axons are displaced and fail to stain with anti-GABA antibodies; PVP neurons also abnormal.ES3 ME2 OA>10: e165, e318, e646 (R44och), e926pdi (deletion), e2505, bx8, etc.). Cloned: encodes predicted 318 aa protein with homeodomain, most similar to UNC-4. Antibody stains D neurons, certain other neurons. Ectopic trans gene expression induces GABA expression. Locus naturally duplicated in some strains. [McIntire et al. 1993; Jin et al. 1994; CZ; MT] | |||||||||
| Strain (18) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (40) | |||||||||
| Paralog (20) | |||||||||
| Structured_description | Concise_description | unc-30 encodes a homeodomain-containing protein that is orthologous to the Pitx family of homeodomain transcription factors; during develpoment, UNC-30 controls the terminal differentiation of all 19 type D GABA-ergic motor neurons by directly regulating the expression of UNC-25/GAD and UNC-47/VGAT, which regulate GABA formation and secretion, respectively; UNC-30 is expressed most strongly in type D motor neurons during early L1 and L2 larval stages. | Paper_evidence | WBPaper00002082 | |||||
| WBPaper00003619 | |||||||||
| WBPaper00004839 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 03 Jul 2007 00:00:00 | ||||||||
| Automated_description | Enables sequence-specific DNA binding activity. Involved in neuron differentiation; positive regulation of transcription by RNA polymerase II; and regulation of locomotion. Located in nucleus. Expressed in GABAergic neurons; ganglia; intestine; and ventral cord neurons. Human ortholog(s) of this gene implicated in Arts syndrome; clubfoot; and eye disease (multiple). Is an ortholog of human PITX2 (paired like homeodomain 2) and PITX3 (paired like homeodomain 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (11) | ||||||||
| Molecular_info | Corresponding_CDS | B0564.10a | |||||||
| B0564.10b | |||||||||
| B0564.10c | |||||||||
| B0564.10d | |||||||||
| Corresponding_CDS_history | B0564.10:wp114 | ||||||||
| Corresponding_transcript | B0564.10a.1 | ||||||||
| B0564.10b.1 | |||||||||
| B0564.10c.1 | |||||||||
| B0564.10d.1 | |||||||||
| Other_sequence | L37867 | ||||||||
| CBC05195_1 | |||||||||
| Acan_isotig10301 | |||||||||
| JI173604.1 | |||||||||
| Dviv_isotig23393 | |||||||||
| CJC03266_1 | |||||||||
| Oden_isotig21606 | |||||||||
| Associated_feature (16) | |||||||||
| Gene_product_binds (51) | |||||||||
| Transcription_factor | WBTranscriptionFactor000218 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00090022 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00077587 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00009866 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00094906 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090181 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089777 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00039208 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077590 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090340 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027624 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (12) | |||||||||
| Drives_construct (13) | |||||||||
| Construct_product | WBCnstr00007867 | ||||||||
| WBCnstr00008192 | |||||||||
| WBCnstr00016792 | |||||||||
| WBCnstr00020007 | |||||||||
| WBCnstr00034163 | |||||||||
| Regulate_expr_cluster | WBPaper00061439:unc-30(ok613)_downregulated | ||||||||
| WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection | |||||||||
| WBPaper00061439:unc-30(ok613)_upregulated | |||||||||
| WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection | |||||||||
| Antibody | WBAntibody00000092 | ||||||||
| Microarray_results (32) | |||||||||
| Expression_cluster (118) | |||||||||
| Interaction (103) | |||||||||
| WBProcess | WBbiopr:00000010 | ||||||||
| Map_info | Map | IV | Position | 8.21927 | Error | 0.023908 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDp3 | |||||||
| sDf21 | |||||||||
| sDf22 | |||||||||
| Positive_clone | B0564 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| CB#RH17 | |||||||||
| Mapping_data | 2_point (10) | ||||||||
| Multi_point (64) | |||||||||
| Pos_neg_data (18) | |||||||||
| Landmark_gene | |||||||||
| Reference (161) | |||||||||
| Method | Gene |
