WormBase Tree Display for Gene: WBGene00006750
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WBGene00006750 | SMap | S_parent | Sequence | T10A3 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | unc | ||||||
Reference_allele | WBVar00142961 | ||||||
Allele (153) | |||||||
Legacy_information | e102 : weak coiler tends to back loopy movement in reverse; fairly active slightly small and thin. ES3 ME2. NA2 (e126). | ||||||
[C.elegansII] e102 : weak coiler, tends to back, loopy movement in reverse; fairly active; slightly small and thin; Ric. ES3 ME2. OA1: e126. [Brenner 1974; Nguyen et al. 1995] | |||||||
[Nonet M] unc-10(e102) was phenotypically rescued by both cosmid C34H12 and a 16 kb BamHI/KpnI subclone of this cosmid that contains effectively only the rim-1 gene. The rim-1 gene (rim for Rab Interacting Molecule) is the combined genefinder products T10A3.1 and K03A1.3 (with several mistakes in the prediction by genefinder). Furthermore, unc-10(md330) and unc-10(md1117) both contain deletions of the vast majority of the rim-1 gene. Specifically, md1117 deleted 8.6 kb that extends from approximately 500 bp 5' of the atg to 200 bp 3' of the TAA of the rim-1 gene product. | |||||||
[Nonet M] Encodes Rab-3 interacting protein. | |||||||
Strain | WBStrain00002752 | ||||||
WBStrain00027194 | |||||||
WBStrain00029061 | |||||||
WBStrain00004100 | |||||||
WBStrain00005485 | |||||||
WBStrain00005508 | |||||||
WBStrain00005509 | |||||||
WBStrain00051853 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (32) | |||||||
Ortholog (51) | |||||||
Structured_description | Concise_description | unc-10 encodes a protein with zinc-finger, Q/N-rich, PDZ, and C2 domains that is homologous to vertebrate Rim1, a presynaptic protein which binds, and effects the activity of, synaptic vesicle-associated GTP-Rab3; UNC-10 is required for normal locomotion and synaptic transmission, and localizes to a subdomain of presynaptic termini, where it probably acts to regulate the priming step of presynaptic vesicle fusion by promoting conformational changes in syntaxin. | Paper_evidence | WBPaper00002487 | |||
WBPaper00004891 | |||||||
WBPaper00005068 | |||||||
WBPaper00012788 | |||||||
WBPaper00012830 | |||||||
WBPaper00012882 | |||||||
WBPaper00012897 | |||||||
WBPaper00013003 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Enables small GTPase binding activity. Involved in several processes, including chemical synaptic transmission; defecation; and positive regulation of cholinergic synaptic transmission. Located in axon and presynaptic active zone. Expressed in dorsal nerve cord; nerve ring; nervous system; uv1; and ventral nerve cord. Is an ortholog of human RIMS1 (regulating synaptic membrane exocytosis 1). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | T10A3.1a | |||||
T10A3.1b | |||||||
T10A3.1c | |||||||
T10A3.1d | |||||||
T10A3.1e | |||||||
T10A3.1f | |||||||
Corresponding_transcript | T10A3.1a.1 | ||||||
T10A3.1b.1 | |||||||
T10A3.1c.1 | |||||||
T10A3.1d.1 | |||||||
T10A3.1e.1 | |||||||
T10A3.1f.1 | |||||||
Other_sequence (30) | |||||||
Associated_feature (22) | |||||||
Experimental_info | RNAi_result (19) | ||||||
Expr_pattern | Chronogram1591 | ||||||
Expr2418 | |||||||
Expr14780 | |||||||
Expr15235 | |||||||
Expr15236 | |||||||
Expr1017493 | |||||||
Expr1032824 | |||||||
Expr1156587 | |||||||
Expr2017837 | |||||||
Expr2035973 | |||||||
Drives_construct | WBCnstr00003280 | ||||||
WBCnstr00034173 | |||||||
Construct_product (11) | |||||||
Antibody | WBAntibody00000412 | ||||||
WBAntibody00000866 | |||||||
WBAntibody00001456 | |||||||
WBAntibody00001656 | |||||||
WBAntibody00001729 | |||||||
WBAntibody00002171 | |||||||
Microarray_results (30) | |||||||
Expression_cluster (208) | |||||||
Interaction (82) | |||||||
Map_info | Map | X | Position | -1.7816 | Error | 0.001118 | |
Well_ordered | |||||||
Positive | Positive_clone | C34H12 | |||||
T10A3 | Person_evidence | WBPerson451 | |||||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
Mapping_data | 2_point | 147 | |||||
182 | |||||||
3912 | |||||||
3913 | |||||||
6198 | |||||||
Multi_point (23) | |||||||
Pos_neg_data (13) | |||||||
Reference (108) | |||||||
Remark | Sequence connection from [Koushika SP, Nonet M] | ||||||
Other name from JA Hodgkin, 09/02/2002 | |||||||
unc-10 is the same as rim-1 and therefore rim-1 was merged into unc-10 based on advice from JAH | |||||||
Method | Gene |