WormBase Tree Display for Gene: WBGene00006750
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| WBGene00006750 | SMap | S_parent | Sequence | T10A3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-10 | Person_evidence | WBPerson261 | |||||
| Sequence_name | T10A3.1 | ||||||||
| Molecular_name (18) | |||||||||
| Other_name | rim-1 | ||||||||
| Rim | Paper_evidence | WBPaper00013595 | |||||||
| CELE_T10A3.1 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | unc-10 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00142961 | ||||||||
| Allele (153) | |||||||||
| Legacy_information | e102 : weak coiler tends to back loopy movement in reverse; fairly active slightly small and thin. ES3 ME2. NA2 (e126). | ||||||||
| [C.elegansII] e102 : weak coiler, tends to back, loopy movement in reverse; fairly active; slightly small and thin; Ric. ES3 ME2. OA1: e126. [Brenner 1974; Nguyen et al. 1995] | |||||||||
| [Nonet M] unc-10(e102) was phenotypically rescued by both cosmid C34H12 and a 16 kb BamHI/KpnI subclone of this cosmid that contains effectively only the rim-1 gene. The rim-1 gene (rim for Rab Interacting Molecule) is the combined genefinder products T10A3.1 and K03A1.3 (with several mistakes in the prediction by genefinder). Furthermore, unc-10(md330) and unc-10(md1117) both contain deletions of the vast majority of the rim-1 gene. Specifically, md1117 deleted 8.6 kb that extends from approximately 500 bp 5' of the atg to 200 bp 3' of the TAA of the rim-1 gene product. | |||||||||
| [Nonet M] Encodes Rab-3 interacting protein. | |||||||||
| Strain | WBStrain00002752 | ||||||||
| WBStrain00027194 | |||||||||
| WBStrain00029061 | |||||||||
| WBStrain00004100 | |||||||||
| WBStrain00005485 | |||||||||
| WBStrain00005508 | |||||||||
| WBStrain00005509 | |||||||||
| WBStrain00051853 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00004030 | ||||||||
| 00004031 | |||||||||
| 00004032 | |||||||||
| 00075066 | |||||||||
| 00075067 | |||||||||
| 00075068 | |||||||||
| 00075069 | |||||||||
| 00075070 | |||||||||
| 00075071 | |||||||||
| 00075072 | |||||||||
| 00075073 | |||||||||
| 00075074 | |||||||||
| 00075075 | |||||||||
| 00075076 | |||||||||
| 00075077 | |||||||||
| 00075078 | |||||||||
| 00075079 | |||||||||
| 00075080 | |||||||||
| 00075081 | |||||||||
| 00075082 | |||||||||
| 00075083 | |||||||||
| 00075084 | |||||||||
| 00075085 | |||||||||
| 00075086 | |||||||||
| 00075087 | |||||||||
| 00075088 | |||||||||
| 00075089 | |||||||||
| 00075090 | |||||||||
| 00075091 | |||||||||
| 00114740 | |||||||||
| 00114741 | |||||||||
| 00114742 | |||||||||
| Ortholog (51) | |||||||||
| Structured_description | Concise_description | unc-10 encodes a protein with zinc-finger, Q/N-rich, PDZ, and C2 domains that is homologous to vertebrate Rim1, a presynaptic protein which binds, and effects the activity of, synaptic vesicle-associated GTP-Rab3; UNC-10 is required for normal locomotion and synaptic transmission, and localizes to a subdomain of presynaptic termini, where it probably acts to regulate the priming step of presynaptic vesicle fusion by promoting conformational changes in syntaxin. | Paper_evidence | WBPaper00002487 | |||||
| WBPaper00004891 | |||||||||
| WBPaper00005068 | |||||||||
| WBPaper00012788 | |||||||||
| WBPaper00012830 | |||||||||
| WBPaper00012882 | |||||||||
| WBPaper00012897 | |||||||||
| WBPaper00013003 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables small GTPase binding activity. Involved in several processes, including chemical synaptic transmission; defecation; and positive regulation of cholinergic synaptic transmission. Located in axon and presynaptic active zone. Expressed in dorsal nerve cord; nerve ring; nervous system; uv1; and ventral nerve cord. Is an ortholog of human RIMS1 (regulating synaptic membrane exocytosis 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T10A3.1a | |||||||
| T10A3.1b | |||||||||
| T10A3.1c | |||||||||
| T10A3.1d | |||||||||
| T10A3.1e | |||||||||
| T10A3.1f | |||||||||
| Corresponding_transcript | T10A3.1a.1 | ||||||||
| T10A3.1b.1 | |||||||||
| T10A3.1c.1 | |||||||||
| T10A3.1d.1 | |||||||||
| T10A3.1e.1 | |||||||||
| T10A3.1f.1 | |||||||||
| Other_sequence (30) | |||||||||
| Associated_feature (22) | |||||||||
| Experimental_info | RNAi_result (19) | ||||||||
| Expr_pattern | Chronogram1591 | ||||||||
| Expr2418 | |||||||||
| Expr14780 | |||||||||
| Expr15235 | |||||||||
| Expr15236 | |||||||||
| Expr1017493 | |||||||||
| Expr1032824 | |||||||||
| Expr1156587 | |||||||||
| Expr2017837 | |||||||||
| Expr2035973 | |||||||||
| Drives_construct | WBCnstr00003280 | ||||||||
| WBCnstr00034173 | |||||||||
| Construct_product (11) | |||||||||
| Antibody | WBAntibody00000412 | ||||||||
| WBAntibody00000866 | |||||||||
| WBAntibody00001456 | |||||||||
| WBAntibody00001656 | |||||||||
| WBAntibody00001729 | |||||||||
| WBAntibody00002171 | |||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (208) | |||||||||
| Interaction (82) | |||||||||
| Map_info | Map | X | Position | -1.7816 | Error | 0.001118 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C34H12 | |||||||
| T10A3 | Person_evidence | WBPerson451 | |||||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | 2_point | 147 | |||||||
| 182 | |||||||||
| 3912 | |||||||||
| 3913 | |||||||||
| 6198 | |||||||||
| Multi_point (23) | |||||||||
| Pos_neg_data (13) | |||||||||
| Reference (108) | |||||||||
| Remark | Sequence connection from [Koushika SP, Nonet M] | ||||||||
| Other name from JA Hodgkin, 09/02/2002 | |||||||||
| unc-10 is the same as rim-1 and therefore rim-1 was merged into unc-10 based on advice from JAH | |||||||||
| Method | Gene |
