WormBase Tree Display for Gene: WBGene00006749

WBGene00006749 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 1
    Name: CGC_name: unc-9 Person_evidence: WBPerson261
      Sequence_name: R12H7.1
      Molecular_name: R12H7.1a
        R12H7.1a.1
        CE28246
        R12H7.1b
        CE51729
        R12H7.1a.2
        R12H7.1b.1
      Other_name: CELE_R12H7.1 Accession_evidence: NDB BX284606
      Public_name: unc-9
    DB_info: Database: AceView gene XN833
        WormQTL gene WBGene00006749
        WormFlux gene WBGene00006749
        NDB locus_tag CELE_R12H7.1
        Panther gene CAEEL|WormBase=WBGene00006749|UniProtKB=O01393
          family PTHR11893
        NCBI gene 181443
        RefSeq protein NM_001330917.4
            NM_171790.8
        SwissProt UniProtAcc O01393
        TrEMBL UniProtAcc A0A1C3NSM1
        UniProt_GCRP UniProtAcc O01393
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:41 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00142960
    Allele (304)
    Legacy_information: e101 : moves backward better than forward slight kinker in forward movement active healthy; larvae more severely uncoordinated; male fan slightly reduced spicules tend to protrude. ES2 ME0. NA2 (e111).
      [C.elegansII] e101 : moves backward better than forward slight kinker in forward movement active healthy; larvae more severely uncoordinated; suppresses anaesthetic hypersensitivity of unc-79 and unc-80; male fan slightly reduced, spicules tend to protrude. ES2 ME0. OA3: e101, ec27, bx5, e111. Cloned: cosmid rescue (R12H7). [Brenner 1974; Morgan and Sedensky 1994; CW; MQ]
    Strain (29)
    RNASeq_FPKM (74)
    GO_annotation (27)
    Ortholog: WBGene00058760 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00027751 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00147912 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00128630 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00096416 Pristionchus pacificus From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00225632 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g3604 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g5537 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g1033 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g14147 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g23027 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g6093 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g12470 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g4941 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g9116 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g6986 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00110.g4591 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-unc-9 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g10134 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00196.g6782 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_01925 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_025398 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g07497 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g16871 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_X0155200 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g20362 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00242150 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00267565 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00285419 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0027108 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      FB:FBgn0027106 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      FB:FBgn0085387 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      FB:FBgn0265274 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      FB:FBgn0004646 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      FB:FBgn0024177 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
    Paralog (24)
    Structured_description: Concise_description: unc-9 encodes an innexin, an integral transmembrane channel protein that is a structural component of invertebrate gap junctions; UNC-9 is required for normal forward locomotion and egg-laying and also plays a role in the response to antihelminthics and volatile anesthetics; UNC-9 may form a functional pair with UNC-7, another C. elegans innexin, as mutations in unc-7 result in defects nearly identical to those in unc-9 mutant animals. Paper_evidence: WBPaper00002950
            WBPaper00004670
            WBPaper00005286
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables actin filament binding activity and gap junction channel activity. Involved in monoatomic ion transmembrane transport and positive regulation of locomotion. Located in gap junction. Expressed in several structures, including anchor cell; muscle cell; neurons; phasmid sheath cell; and somatic nervous system. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: R12H7.1a
      R12H7.1b
    Corresponding_CDS_history: R12H7.1:wp52
    Corresponding_transcript: R12H7.1a.1
      R12H7.1a.2
      R12H7.1b.1
    Other_sequence (38)
    Associated_feature (22)
  Experimental_info: RNAi_result: WBRNAi00089959 Inferred_automatically: RNAi_primary
      WBRNAi00027706 Inferred_automatically: RNAi_primary
      WBRNAi00101970 Inferred_automatically: RNAi_primary
      WBRNAi00090119 Inferred_automatically: RNAi_primary
      WBRNAi00101969 Inferred_automatically: RNAi_primary
      WBRNAi00101971 Inferred_automatically: RNAi_primary
      WBRNAi00051863 Inferred_automatically: RNAi_primary
      WBRNAi00090277 Inferred_automatically: RNAi_primary
      WBRNAi00089762 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00005223
      WBCnstr00011756
      WBCnstr00012540
      WBCnstr00013463
      WBCnstr00016962
      WBCnstr00018785
      WBCnstr00019879
      WBCnstr00034174
      WBCnstr00042717
    Construct_product: WBCnstr00004912
      WBCnstr00007077
      WBCnstr00014822
      WBCnstr00017891
      WBCnstr00018129
      WBCnstr00019880
      WBCnstr00021094
      WBCnstr00022772
      WBCnstr00022774
      WBCnstr00034174
    Antibody: WBAntibody00001277
      WBAntibody00001907
    Microarray_results (20)
    Expression_cluster (186)
    Interaction (65)
  Map_info: Map: X Position: 10.2432 Error: 0.033106
    Well_ordered
    Positive: Inside_rearr: yDp4
        yDp5
        yDp6
        yDp7
        yDp8
        yDp9
        yDp10
        yDp11
        yDp12
      Positive_clone: R12H7 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 179
        189
        190
        280
        419
        3152
        3666
        3914
        5007
        6063
        6105
        6123
        6161
        7097
        7133
      Multi_point (65)
      Pos_neg_data (29)
    Landmark_gene
  Reference (101)
  Method: Gene