WormBase Tree Display for Gene: WBGene00006706
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| WBGene00006706 | SMap | S_parent | Sequence | F29B9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | ubc-9 | Person_evidence | WBPerson89 | |||||
| Sequence_name | F29B9.6 | ||||||||
| Molecular_name | F29B9.6 | ||||||||
| F29B9.6.1 | |||||||||
| CE09784 | |||||||||
| Other_name | UBC9 | Paper_evidence | WBPaper00038372 | ||||||
| CELE_F29B9.6 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | ubc-9 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ubc | ||||||||
| Allele (21) | |||||||||
| Strain | WBStrain00004050 | ||||||||
| WBStrain00034466 | |||||||||
| WBStrain00034467 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (33) | |||||||||
| Contained_in_operon | CEOP4128 | ||||||||
| Ortholog (41) | |||||||||
| Paralog (18) | |||||||||
| Structured_description | Concise_description | ubc-9 encodes an E2 ubiquitin-conjugating enzyme orthologous to Saccharomyces cerevisiae Ubc9p, which mediates the covalent attachment of the small ubiquitin-related modifier (SUMO) to various substrates including Ran-GAP1 and p53; UBC-9 activity is required for several developmental processes including embryogenesis, larval development, vulval development, posterior morphogenesis, and the DNA damage response (both DNA repair and DNA damage checkpoint function); UBC-9 interacts with LIN-1, an ETS-domain-containing transcription factor that negatively regulates vulval development, and with RAD-51, the C. elegans RecA homolog that is required for DNA repair. | Paper_evidence | WBPaper00005039 | |||||
| WBPaper00005337 | |||||||||
| WBPaper00012383 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; SAM domain binding activity; and SUMO conjugating enzyme activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; pharyngeal muscle development; and protein sumoylation. Predicted to be located in nucleus. Expressed in body wall musculature; coelomocyte; pharynx; tail; and in male. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; ovarian cancer; and urinary bladder cancer. Is an ortholog of human UBE2I (ubiquitin conjugating enzyme E2 I). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:11054 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12485) | ||||
| DOID:12930 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12485) | ||||||
| DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12485) | ||||||
| Molecular_info | Corresponding_CDS | F29B9.6 | |||||||
| Corresponding_transcript | F29B9.6.1 | ||||||||
| Other_sequence (69) | |||||||||
| Associated_feature | WBsf645940 | ||||||||
| WBsf645941 | |||||||||
| WBsf981746 | |||||||||
| WBsf996355 | |||||||||
| WBsf228217 | |||||||||
| WBsf228218 | |||||||||
| Experimental_info | RNAi_result (65) | ||||||||
| Expr_pattern | Expr11863 | ||||||||
| Expr13765 | |||||||||
| Expr1015118 | |||||||||
| Expr1032789 | |||||||||
| Expr1149806 | |||||||||
| Expr2017717 | |||||||||
| Expr2035855 | |||||||||
| Drives_construct | WBCnstr00019675 | ||||||||
| WBCnstr00034201 | |||||||||
| Construct_product | WBCnstr00034201 | ||||||||
| Regulate_expr_cluster | WBPaper00045390:ubc-9(RNAi)_downregulated | ||||||||
| WBPaper00045390:ubc-9(RNAi)_upregulated | |||||||||
| WBPaper00061479:ubc-9(ne4833)_upregulated | |||||||||
| Antibody | WBAntibody00002527 | ||||||||
| WBAntibody00002604 | |||||||||
| Microarray_results (28) | |||||||||
| Expression_cluster (150) | |||||||||
| Interaction (181) | |||||||||
| Map_info | Map | IV | Position | 0.518478 | Error | 0.015777 | |||
| Positive | Positive_clone | F29B9 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (41) | |||||||||
| Remark | Sequence connection from [Jones D, Crowe E, Stevens TA, Candido EPM], 02/06/10 krb. | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
