WormBase Tree Display for Gene: WBGene00006706
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WBGene00006706 | SMap | S_parent | Sequence | F29B9 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | ubc-9 | Person_evidence | WBPerson89 | |||||
Sequence_name | F29B9.6 | ||||||||
Molecular_name | F29B9.6 | ||||||||
F29B9.6.1 | |||||||||
CE09784 | |||||||||
Other_name | UBC9 | Paper_evidence | WBPaper00038372 | ||||||
CELE_F29B9.6 | Accession_evidence | NDB | BX284604 | ||||||
Public_name | ubc-9 | ||||||||
DB_info | Database (12) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | ubc | ||||||||
Allele (21) | |||||||||
Strain | WBStrain00004050 | ||||||||
WBStrain00034466 | |||||||||
WBStrain00034467 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (33) | |||||||||
Contained_in_operon | CEOP4128 | ||||||||
Ortholog (41) | |||||||||
Paralog (18) | |||||||||
Structured_description | Concise_description | ubc-9 encodes an E2 ubiquitin-conjugating enzyme orthologous to Saccharomyces cerevisiae Ubc9p, which mediates the covalent attachment of the small ubiquitin-related modifier (SUMO) to various substrates including Ran-GAP1 and p53; UBC-9 activity is required for several developmental processes including embryogenesis, larval development, vulval development, posterior morphogenesis, and the DNA damage response (both DNA repair and DNA damage checkpoint function); UBC-9 interacts with LIN-1, an ETS-domain-containing transcription factor that negatively regulates vulval development, and with RAD-51, the C. elegans RecA homolog that is required for DNA repair. | Paper_evidence | WBPaper00005039 | |||||
WBPaper00005337 | |||||||||
WBPaper00012383 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; SAM domain binding activity; and SUMO conjugating enzyme activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; pharyngeal muscle development; and protein sumoylation. Predicted to be located in nucleus. Expressed in body wall musculature; coelomocyte; pharynx; tail; and in male. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; ovarian cancer; and urinary bladder cancer. Is an ortholog of human UBE2I (ubiquitin conjugating enzyme E2 I). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed (2) | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:11054 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12485) | ||||
DOID:12930 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12485) | ||||||
DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12485) | ||||||
Molecular_info | Corresponding_CDS | F29B9.6 | |||||||
Corresponding_transcript | F29B9.6.1 | ||||||||
Other_sequence (69) | |||||||||
Associated_feature | WBsf645940 | ||||||||
WBsf645941 | |||||||||
WBsf981746 | |||||||||
WBsf996355 | |||||||||
WBsf228217 | |||||||||
WBsf228218 | |||||||||
Experimental_info | RNAi_result (65) | ||||||||
Expr_pattern | Expr11863 | ||||||||
Expr13765 | |||||||||
Expr1015118 | |||||||||
Expr1032789 | |||||||||
Expr1149806 | |||||||||
Expr2017717 | |||||||||
Expr2035855 | |||||||||
Drives_construct | WBCnstr00019675 | ||||||||
WBCnstr00034201 | |||||||||
Construct_product | WBCnstr00034201 | ||||||||
Regulate_expr_cluster | WBPaper00045390:ubc-9(RNAi)_downregulated | ||||||||
WBPaper00045390:ubc-9(RNAi)_upregulated | |||||||||
WBPaper00061479:ubc-9(ne4833)_upregulated | |||||||||
Antibody | WBAntibody00002527 | ||||||||
WBAntibody00002604 | |||||||||
Microarray_results (28) | |||||||||
Expression_cluster (150) | |||||||||
Interaction (181) | |||||||||
Map_info | Map | IV | Position | 0.518478 | Error | 0.015777 | |||
Positive | Positive_clone | F29B9 | Inferred_automatically | From CDS info | |||||
From sequence, transcript, pseudogene data | |||||||||
Pseudo_map_position | |||||||||
Reference (41) | |||||||||
Remark | Sequence connection from [Jones D, Crowe E, Stevens TA, Candido EPM], 02/06/10 krb. | ||||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
Method | Gene |