WormBase Tree Display for Gene: WBGene00006667

WBGene00006667 Evidence: Person_evidence: WBPerson655
  SMap: S_parent: Sequence: F29F11
  Identity: Version: 1
    Name: CGC_name: twk-12 Person_evidence: WBPerson655
      Sequence_name: F29F11.4
      Molecular_name: F29F11.4
        F29F11.4.1
        CE48353
      Other_name: twk-9 Person_evidence: WBPerson655
        CELE_F29F11.4 Accession_evidence: NDB BX284605
      Public_name: twk-12
    DB_info: Database: AceView gene 5L149
        WormQTL gene WBGene00006667
        WormFlux gene WBGene00006667
        NDB locus_tag CELE_F29F11.4
        Panther gene CAEEL|WormBase=WBGene00006667|UniProtKB=Q19907
          family PTHR11003
        NCBI gene 192074
        RefSeq protein NM_073330.5
        SwissProt UniProtAcc Q19907
        UniProt_GCRP UniProtAcc Q19907
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:41 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: twk
    Allele (43)
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog (32)
    Paralog (47)
    Structured_description: Concise_description: twk-12 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; as loss of TWK-12 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of TWK-12 in C. elegans development and/or behavior is not yet known; TWK-12 may, however, function redundantly with other TWK channels; the TWK-12 expression pattern has not been determined. Paper_evidence: WBPaper00004644
            WBPaper00005654
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be located in membrane. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F29F11.4
    Corresponding_CDS_history: F29F11.4:wp131
      F29F11.4:wp237
    Corresponding_transcript: F29F11.4.1
    Associated_feature: WBsf1001160
      WBsf1001161
      WBsf1020331
      WBsf232408
  Experimental_info: RNAi_result: WBRNAi00045933 Inferred_automatically: RNAi_primary
      WBRNAi00014110 Inferred_automatically: RNAi_primary
    Expr_pattern (4)
    Microarray_results (17)
    Expression_cluster: WBPaper00030922:glycosylated_protein
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032425:down_in_alg-1
      WBPaper00032425:down_in_lin-35
      WBPaper00032425:down_in_zfp-1
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_CoreEnriched
      WBPaper00037950:bodywall-muscle_embryo_enriched
      WBPaper00037950:bodywall-muscle_embryo_SelectivelyEnriched
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_larva_enriched
      WBPaper00037950:bodywall-muscle_larva_SelectivelyEnriched
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044656:tatn-1(qd182)_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045050:csr-1(hypomorph)_upregulated
      WBPaper00045417:128Q-huntingtin_upreglated
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
      WBPaper00046509:htz-1(ok3099)_downregulated
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:body-muscle_enriched
      WBPaper00050990:body-muscle_expressed
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056809:smn-1(ok355)_upregulated
      WBPaper00056826:hmc_biased
      WBPaper00057068:ints-4(RNAi)_upregulated
      WBPaper00058711:wdr-5(ok1417)_upregulated
      WBPaper00058725:sftb-1(cer6)_upregulated
      WBPaper00058725:sftb-1(cer39)_upregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061040:eat-2(ad1116)_upregulated
      WBPaper00061340:pm3_pm4_pm5
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061527:ckr-1-T09B9.3
      WBPaper00061653:alh-4(hj221)_upregulated
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065841:4_0
      WBPaper00065841:23_0
      WBPaper00065841:46_0
      WBPaper00065841:70_0
      WBPaper00065841:102_0
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066110:Cisplatin_downregulated_diploid
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4489_group_17
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00031003:24hr_muscle_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00034661:AgNPs_downregulated
      WBPaper00035227:heat_shock_regulated
      WBPaper00040184:hcf-1down_sir-2.1nc_daf-2nc
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042548:miRISC_enriched
      WBPaper00044091:Bpseudomallei_induced_12h
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00048563:L1_DD_enriched
      WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO
    Interaction: WBInteraction000121778
      WBInteraction000133844
      WBInteraction000138601
      WBInteraction000566457
      WBInteraction000566736
      WBInteraction000580459
  Map_info: Map: V Position: 2.70767 Error: 0.000525
    Positive: Positive_clone: F29F11 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00006402
    WBPaper00013489
    WBPaper00026748
    WBPaper00038491
    WBPaper00055090
  Remark: twk-12 was connected to K01D12.4 CGC_data_submission
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene