WormBase Tree Display for Gene: WBGene00006652
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| WBGene00006652 | SMap | S_parent | Sequence | Y113G7A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | ttx-1 | Person_evidence | WBPerson1417 | |||||
| Sequence_name | Y113G7A.6 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | EH67 | Paper_evidence | WBPaper00000161 | ||||||
| PR767 | Paper_evidence | WBPaper00000680 | |||||||
| CELE_Y113G7A.6 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | ttx-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ttx | ||||||||
| Allele (456) | |||||||||
| Possibly_affected_by | WBVar02158831 | ||||||||
| Legacy_information | [C.elegansII] p767 : mutant animals strongly cryophilic; hypersensitiveto dauer pheromone; neuron AFD lacks "fingers" (microvilli). [Perkins et al. 1986; FK] | ||||||||
| Strain | WBStrain00030792 | ||||||||
| WBStrain00031125 | |||||||||
| WBStrain00031126 | |||||||||
| WBStrain00037604 | |||||||||
| WBStrain00049306 | |||||||||
| WBStrain00048958 | |||||||||
| WBStrain00052015 | |||||||||
| WBStrain00055050 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (44) | |||||||||
| Ortholog (37) | |||||||||
| Paralog (20) | |||||||||
| Structured_description | Concise_description | ttx-1 encodes a homeodomain protein that is a member of the OTD/OTX subclass of homeodomain transcription factors; ttx-1 is expressed at higher levels in the AFD thermosensory neurons as compared to the AWB olfactory neurons and is necessary and partly sufficient for specification of the AFD thermosensory neuron fate and thus for proper AFD-mediated thermosensory behavior and normal expression of genes such as gcy-8, nhr-38, ceh-14, tax-2, and dac-1; TTX-1 is also required for remodeling of glial cells during dauer larval development which is mediated by regulation of ver-1 expression; a TTX-1::GFP fusion protein is nuclear and expressed in the AFD neurons and the nine pharyngeal marginal cells. | Paper_evidence | WBPaper00000161 | |||||
| WBPaper00004879 | |||||||||
| WBPaper00024671 | |||||||||
| WBPaper00040681 | |||||||||
| WBPaper00038156 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 08 Apr 2014 00:00:00 | ||||||||
| Automated_description | Enables DNA-binding transcription factor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including regulation of plasma membrane bounded cell projection assembly; thermosensory behavior; and transcription by RNA polymerase II. Located in nucleus. Expressed in head neurons and pharyngeal cell. Human ortholog(s) of this gene implicated in panhypopituitarism and syndromic microphthalmia 5. Is an ortholog of human OTX1 (orthodenticle homeobox 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111806 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8522) | ||||
| DOID:9410 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8522) | ||||||
| Molecular_info | Corresponding_CDS | Y113G7A.6a | |||||||
| Y113G7A.6b | |||||||||
| Y113G7A.6c | |||||||||
| Y113G7A.6d | |||||||||
| Corresponding_CDS_history | Y113G7A.6a:wp80 | ||||||||
| Y113G7A.6b:wp80 | |||||||||
| Corresponding_transcript | Y113G7A.6a.1 | ||||||||
| Y113G7A.6b.1 | |||||||||
| Y113G7A.6c.1 | |||||||||
| Y113G7A.6d.1 | |||||||||
| Other_sequence (37) | |||||||||
| Associated_feature (15) | |||||||||
| Gene_product_binds | WBsf980903 | ||||||||
| WBsf980905 | |||||||||
| WBsf980906 | |||||||||
| Transcription_factor | WBTranscriptionFactor000216 | ||||||||
| Experimental_info (9) | |||||||||
| Map_info | Map | V | Position | 24.5199 | Error | 0.016963 | |||
| Positive | Positive_clone | Y113G7A | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4325 | |||||||
| 4745 | |||||||||
| 5371 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (90) | |||||||||
| Remark | Sequence connection from [Satterlee JS, Sengupta P] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
