WormBase Tree Display for Gene: WBGene00006575
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| WBGene00006575 | SMap | S_parent | Sequence | F13B10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | tir-1 | Person_evidence | WBPerson168 | |||||
| Sequence_name | F13B10.1 | ||||||||
| Molecular_name (29) | |||||||||
| Other_name | nsy-2 | Paper_evidence | WBPaper00024676 | ||||||
| Person_evidence | WBPerson42 | ||||||||
| CELE_F13B10.1 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | tir-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 09 Nov 2005 10:42:10 | WBPerson2970 | Event | Acquires_merge | WBGene00003823 | ||||
| Name_change | Other_name | nsy-2 | |||||||
| Acquires_merge | WBGene00003823 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | tir | ||||||||
| Allele (424) | |||||||||
| Possibly_affected_by | WBVar02152927 | ||||||||
| Strain | WBStrain00031789 | ||||||||
| WBStrain00032827 | |||||||||
| WBStrain00035844 | |||||||||
| WBStrain00040806 | |||||||||
| WBStrain00005265 | |||||||||
| WBStrain00021983 | |||||||||
| WBStrain00021984 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (53) | |||||||||
| Ortholog (53) | |||||||||
| Structured_description | Concise_description | tir-1 encodes a Toll-Interleukin 1 Receptor (TIR) domain adaptor protein that is the C. elegans ortholog of human SARM (sterile alpha and armadillo repeats); tir-1 is required for innate immunity, as loss of tir-1 activity results in increased susceptibility to infection; tir-1 also functions in a lateral signaling pathway that specifies neuronal identity and is required for proper localization of NSY-1/MAPKKK to post-synaptic regions; TIR-1 physically interacts with a number of proteins, including UNC-43/CaMKII, the RAB-1 GTPase, and the ATP synthase f subunit encoded by R53.4; TIR-1 is expressed in neurons and localizes to post-synaptic regions of axons. | Paper_evidence | WBPaper00004589 | |||||
| WBPaper00006488 | |||||||||
| WBPaper00006511 | |||||||||
| WBPaper00024676 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 22 Mar 2013 00:00:00 | ||||||||
| Automated_description | Enables several functions, including NAD+ nucleosidase activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including NAD catabolic process; defense response to other organism; and regulation of gene expression. Acts upstream of or within serotonin biosynthetic process. Located in axon cytoplasm and cell body. Expressed in head. Used to study amyotrophic lateral sclerosis. Is an ortholog of human SARM1 (sterile alpha and TIR motif containing 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:332 | Homo sapiens | Paper_evidence | WBPaper00046914 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 15 Jul 2015 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000352 | ||||||||
| Molecular_info | Corresponding_CDS | F13B10.1a | |||||||
| F13B10.1b | |||||||||
| F13B10.1c | |||||||||
| F13B10.1d | |||||||||
| F13B10.1e | |||||||||
| F13B10.1f | |||||||||
| F13B10.1g | |||||||||
| F13B10.1h | |||||||||
| Corresponding_CDS_history | F13B10.1c:wp248 | ||||||||
| Corresponding_transcript (13) | |||||||||
| Other_sequence (45) | |||||||||
| Associated_feature (48) | |||||||||
| Experimental_info | RNAi_result (53) | ||||||||
| Expr_pattern | Expr3964 | ||||||||
| Expr3965 | |||||||||
| Expr5747 | |||||||||
| Expr14886 | |||||||||
| Expr1025922 | |||||||||
| Expr1032710 | |||||||||
| Expr1148422 | |||||||||
| Expr2017410 | |||||||||
| Expr2035549 | |||||||||
| Drives_construct | WBCnstr00002582 | ||||||||
| WBCnstr00006461 | |||||||||
| Construct_product (18) | |||||||||
| Antibody | WBAntibody00001006 | ||||||||
| WBAntibody00001007 | |||||||||
| Microarray_results (57) | |||||||||
| Expression_cluster (277) | |||||||||
| Interaction (168) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| WBbiopr:00000008 | |||||||||
| WBbiopr:00000014 | |||||||||
| WBbiopr:00000039 | |||||||||
| Map_info | Map | III | Position | -4.2469 | Error | 0.000352 | |||
| Positive | Positive_clone | F13B10 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4791 | |||||||
| 5662 | |||||||||
| Pos_neg_data | 10953 | ||||||||
| 10954 | |||||||||
| 10955 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (122) | |||||||||
| Picture | WBPicture0000013079 | ||||||||
| WBPicture0000013081 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
