WormBase Tree Display for Gene: WBGene00006369
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| WBGene00006369 | SMap | S_parent | Sequence | R03E1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | sym-4 | Person_evidence | WBPerson252 | |||||
| Sequence_name | R03E1.1 | ||||||||
| Molecular_name | R03E1.1 | ||||||||
| R03E1.1.1 | |||||||||
| CE18901 | |||||||||
| Other_name | CELE_R03E1.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | sym-4 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sym | ||||||||
| Allele (116) | |||||||||
| Legacy_information | [Herman RK] sym-4(mn619) or sym-4(mn620) by itself is essentially wild type but is synthetic lethal with any mec-8 loss-of-function mutation | ||||||||
| Strain | WBStrain00003499 | ||||||||
| WBStrain00034406 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| Contained_in_operon | CEOPX128 | ||||||||
| Ortholog (37) | |||||||||
| Structured_description | Concise_description | sym-4 encodes a large (1,043-residue) protein that is required for viability in a mec-8 mutant background, and is also required by itself for normally rapid growth and locomotion; SYM-4 is orthologous to human WDR44, and has a nondescript N-terminal domain, with a C-terminal domain containing seven WD repeats; SYM-4 is broadly expressed, in larval and adult pharynx, digestive tract, neurons, vulva, body wall muscle, and coelomocytes; sym-4 is synthetically lethal with mec-8, with double mutants showing an abnormally buccal cavity between the anterior end of the embryo and the internal anterior end of the pharyngeal primordium; mec-8;sym-4 embryos arrest development at hatching, are unable to eat, and thus die; SYM-4 may function in concert with SYM-3, since sym-3 mutants have the same synthetic lethal phenotype as sym-4. | Paper_evidence | WBPaper00003663 | |||||
| WBPaper00006395 | |||||||||
| WBPaper00006525 | |||||||||
| WBPaper00024639 | |||||||||
| WBPaper00031006 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 03 Jan 2008 00:00:00 | ||||||||
| Automated_description | Enriched in several structures, including ABalapapap; ABalapppap; excretory cell; head mesodermal cell; and neurons based on microarray; tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including daf-12; hsf-1; and sir-2.1 based on microarray; tiling array; and RNA-seq studies. Is affected by four chemicals including rotenone; stavudine; and fluvastatin based on RNA-seq and microarray studies. Human WDR44 enables molecular sequestering activity and small GTPase binding activity. Is predicted to encode a protein with the following domains: WD repeat-containing protein WDR44/Dgr2; WD domain, G-beta repeat; WD40-repeat-containing domain superfamily; WD40/YVTN repeat-like-containing domain superfamily; WD40 repeat; and Phosphorylation site. Is an ortholog of human WDR44 (WD repeat domain 44). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | R03E1.1 | |||||||
| Corresponding_transcript | R03E1.1.1 | ||||||||
| Other_sequence (31) | |||||||||
| Associated_feature | WBsf654560 | ||||||||
| WBsf671239 | |||||||||
| WBsf982278 | |||||||||
| WBsf1007841 | |||||||||
| WBsf1007842 | |||||||||
| WBsf238203 | |||||||||
| WBsf238204 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00062558 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00000324 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00017353 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00026014 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00034557 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00051178 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027424 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062557 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram453 | ||||||||
| Expr6450 | |||||||||
| Expr1025719 | |||||||||
| Expr1032568 | |||||||||
| Expr1154885 | |||||||||
| Expr2017182 | |||||||||
| Expr2035318 | |||||||||
| Drives_construct | WBCnstr00003957 | ||||||||
| WBCnstr00034385 | |||||||||
| Construct_product | WBCnstr00034385 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (97) | |||||||||
| Interaction (27) | |||||||||
| Map_info | Map | X | Position | 16.6582 | Error | 0.012267 | |||
| Positive | Inside_rearr | mnDp1 | |||||||
| Positive_clone | R03E1 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Negative | Outside_rearr | mnDf19 | |||||||
| Mapping_data | 2_point | 7094 | |||||||
| 7095 | |||||||||
| Multi_point | 4152 | ||||||||
| Pos_neg_data | 10233 | ||||||||
| 10234 | |||||||||
| Reference (14) | |||||||||
| Method | Gene |
