WormBase Tree Display for Gene: WBGene00006368
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| WBGene00006368 | SMap | S_parent | Sequence | C54H2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | sym-3 | Person_evidence | WBPerson252 | |||||
| Sequence_name | C54H2.1 | ||||||||
| Molecular_name | C54H2.1a | ||||||||
| C54H2.1a.1 | |||||||||
| CE38303 | |||||||||
| C54H2.1b | |||||||||
| CE38304 | |||||||||
| C54H2.1a.2 | |||||||||
| C54H2.1b.1 | |||||||||
| C54H2.1b.2 | |||||||||
| Other_name | CELE_C54H2.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | sym-3 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00006368 | |||||
| WormFlux | gene | WBGene00006368 | |||||||
| NDB | locus_tag | CELE_C54H2.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006368|UniProtKB=Q86GI2 | |||||||
| family | PTHR21456 | ||||||||
| NCBI | gene | 183819 | |||||||
| RefSeq | protein | NM_001029329.8 | |||||||
| NM_001029330.3 | |||||||||
| TREEFAM | TREEFAM_ID | TF320966 | |||||||
| TrEMBL | UniProtAcc | Q86GI2 | |||||||
| G5EE38 | |||||||||
| UniProt_GCRP | UniProtAcc | Q86GI2 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sym | ||||||||
| Allele (67) | |||||||||
| Legacy_information | [Herman RK] sym-3(mn618) by itself is essentially wild type but is synthetic lethal with any mec-8 loss-of-function mutation | ||||||||
| Strain | WBStrain00034405 | ||||||||
| WBStrain00034416 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| Ortholog (40) | |||||||||
| Structured_description | Concise_description | sym-3 encodes, by alternative splicing, two isoforms of a protein withno recognizably conserved domains, but with orthology to human FAM102A (EEIG1; OMIM:610891) and FAM102B, and to Drosophila CG8671; mutations in sym-3, while producing no phenotype on their own, are synthetically lethal with loss-of-function mutations in mec-8, which encodes a regulator of alternative RNA splicing; although the precise function of sym-3 is not yet known, sym-3 activity appears to be required for some aspects of pharyngeal differentiation, as mec-8; sym-3 double mutants arrest as late-stage embryos or L1 larvae with pharynges that, despite normal morphology, do not attach to the outer cuticle to allow for feeding. | Paper_evidence | WBPaper00003663 | |||||
| WBPaper00024639 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 04 May 2006 00:00:00 | ||||||||
| Automated_description | Enriched in several structures, including ABalapapapa; ABalapppapa; ABplpaaappa; ABprpaaappa; and head neurons based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including daf-16; daf-12; and eat-2 based on microarray; RNA-seq; and tiling array studies. Is affected by eight chemicals including Lithium Chloride; Zidovudine; and allantoin based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: NT-type C2 domain; EEIG1/2-like; and N-terminal C2 in EEIG1 and EHBP1 proteins. Is an ortholog of human EEIG1 (estrogen-induced osteoclastogenesis regulator 1) and EEIG2 (EEIG family member 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C54H2.1a | |||||||
| C54H2.1b | |||||||||
| Corresponding_CDS_history | C54H2.1:wp107 | ||||||||
| C54H2.1:wp141 | |||||||||
| Corresponding_transcript | C54H2.1a.1 | ||||||||
| C54H2.1a.2 | |||||||||
| C54H2.1b.1 | |||||||||
| C54H2.1b.2 | |||||||||
| Other_sequence (21) | |||||||||
| Associated_feature | WBsf1005379 | ||||||||
| WBsf1005380 | |||||||||
| WBsf1023007 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00043193 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00030166 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062556 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062555 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1020038 | ||||||||
| Expr1032567 | |||||||||
| Expr1147171 | |||||||||
| Expr2017181 | |||||||||
| Expr2035317 | |||||||||
| Drives_construct | WBCnstr00034386 | ||||||||
| Construct_product | WBCnstr00016047 | ||||||||
| WBCnstr00034386 | |||||||||
| Microarray_results (27) | |||||||||
| Expression_cluster (82) | |||||||||
| Interaction | WBInteraction000052796 | ||||||||
| WBInteraction000134120 | |||||||||
| WBInteraction000134122 | |||||||||
| WBInteraction000142067 | |||||||||
| WBInteraction000318693 | |||||||||
| WBInteraction000434495 | |||||||||
| Map_info | Map | X | Position | -4.37222 | Error | 0.007269 | |||
| Positive | Positive_clone | C54H2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 7092 | |||||||
| 7093 | |||||||||
| Reference (16) | |||||||||
| Method | Gene |
