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WormBase Tree Display for Gene: WBGene00006368

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Name Class

WBGene00006368SMapS_parentSequenceC54H2
IdentityVersion1
NameCGC_namesym-3Person_evidenceWBPerson252
Sequence_nameC54H2.1
Molecular_nameC54H2.1a
C54H2.1a.1
CE38303
C54H2.1b
CE38304
C54H2.1a.2
C54H2.1b.1
C54H2.1b.2
Other_nameCELE_C54H2.1Accession_evidenceNDBBX284606
Public_namesym-3
DB_infoDatabaseWormQTLgeneWBGene00006368
WormFluxgeneWBGene00006368
NDBlocus_tagCELE_C54H2.1
PanthergeneCAEEL|WormBase=WBGene00006368|UniProtKB=Q86GI2
familyPTHR21456
NCBIgene183819
RefSeqproteinNM_001029329.8
NM_001029330.3
TREEFAMTREEFAM_IDTF320966
TrEMBLUniProtAccQ86GI2
G5EE38
UniProt_GCRPUniProtAccQ86GI2
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:40WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classsym
Allele (67)
Legacy_information[Herman RK] sym-3(mn618) by itself is essentially wild type but is synthetic lethal with any mec-8 loss-of-function mutation
StrainWBStrain00034405
WBStrain00034416
RNASeq_FPKM (74)
OrthologWBGene00051623Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00035152Caenorhabditis briggsaeFrom_analysisOrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00150809Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00096559Pristionchus pacificusFrom_analysisOMA
Inparanoid_8
WormBase-Compara
WBGene00134757Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00223207Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g2622Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g14402Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g7764Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g10592Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g2561Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g16019Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g172Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g10423Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g7951Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g14009Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cni-sym-3Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold626.g6574Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00027.g1556Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_00465Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_024469Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g04380Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g20014Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_X0234600Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrX_pilon.g19118Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00240033Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00258408Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00289519Trichuris murisFrom_analysisWormBase-Compara
SGD:S000000182Saccharomyces cerevisiaeFrom_analysisOrthoFinder
Panther
FB:FBgn0032938Drosophila melanogasterFrom_analysisEnsEMBL-Compara
OrthoFinder
OrthoInspector
Panther
PhylomeDB
ZFIN:ZDB-GENE-041014-330Danio rerioFrom_analysisEnsEMBL-Compara
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-060616-312Danio rerioFrom_analysisEnsEMBL-Compara
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-060929-412Danio rerioFrom_analysisEnsEMBL-Compara
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-081104-233Danio rerioFrom_analysisEnsEMBL-Compara
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:27637Homo sapiensFrom_analysisEnsEMBL-Compara
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:31419Homo sapiensFrom_analysisEnsEMBL-Compara
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:2138935Mus musculusFrom_analysisEnsEMBL-Compara
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:3036259Mus musculusFrom_analysisEnsEMBL-Compara
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:1310037Rattus norvegicusFrom_analysisEnsEMBL-Compara
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:1597535Rattus norvegicusFrom_analysisEnsEMBL-Compara
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
Structured_descriptionConcise_descriptionsym-3 encodes, by alternative splicing, two isoforms of a protein withno recognizably conserved domains, but with orthology to human FAM102A (EEIG1; OMIM:610891) and FAM102B, and to Drosophila CG8671; mutations in sym-3, while producing no phenotype on their own, are synthetically lethal with loss-of-function mutations in mec-8, which encodes a regulator of alternative RNA splicing; although the precise function of sym-3 is not yet known, sym-3 activity appears to be required for some aspects of pharyngeal differentiation, as mec-8; sym-3 double mutants arrest as late-stage embryos or L1 larvae with pharynges that, despite normal morphology, do not attach to the outer cuticle to allow for feeding.Paper_evidenceWBPaper00003663
WBPaper00024639
Curator_confirmedWBPerson1843
Date_last_updated04 May 2006 00:00:00
Automated_descriptionEnriched in several structures, including ABalapapapa; ABalapppapa; ABplpaaappa; ABprpaaappa; and head neurons based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including daf-16; daf-12; and eat-2 based on microarray; RNA-seq; and tiling array studies. Is affected by eight chemicals including Lithium Chloride; Zidovudine; and allantoin based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: NT-type C2 domain; EEIG1/2-like; and N-terminal C2 in EEIG1 and EHBP1 proteins. Is an ortholog of human EEIG1 (estrogen-induced osteoclastogenesis regulator 1) and EEIG2 (EEIG family member 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSC54H2.1a
C54H2.1b
Corresponding_CDS_historyC54H2.1:wp107
C54H2.1:wp141
Corresponding_transcriptC54H2.1a.1
C54H2.1a.2
C54H2.1b.1
C54H2.1b.2
Other_sequence (21)
Associated_featureWBsf1005379
WBsf1005380
WBsf1023007
Experimental_infoRNAi_resultWBRNAi00043193Inferred_automaticallyRNAi_primary
WBRNAi00030166Inferred_automaticallyRNAi_primary
WBRNAi00062556Inferred_automaticallyRNAi_primary
WBRNAi00062555Inferred_automaticallyRNAi_primary
Expr_patternExpr1020038
Expr1032567
Expr1147171
Expr2017181
Expr2035317
Drives_constructWBCnstr00034386
Construct_productWBCnstr00016047
WBCnstr00034386
Microarray_results (27)
Expression_cluster (82)
InteractionWBInteraction000052796
WBInteraction000134120
WBInteraction000134122
WBInteraction000142067
WBInteraction000318693
WBInteraction000434495
Map_infoMapXPosition-4.37222Error0.007269
PositivePositive_cloneC54H2Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point7092
7093
Reference (16)
MethodGene