WormBase Tree Display for Gene: WBGene00006321
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| WBGene00006321 | SMap | S_parent | Sequence | T22B2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | sup-12 | Paper_evidence | WBPaper00024604 | |||||
| WBPaper00000807 | |||||||||
| Sequence_name | T22B2.4 | ||||||||
| Molecular_name | T22B2.4a | ||||||||
| T22B2.4a.1 | |||||||||
| CE13934 | |||||||||
| T22B2.4b | |||||||||
| CE42801 | |||||||||
| T22B2.4b.1 | |||||||||
| T22B2.4b.2 | |||||||||
| Other_name | CELE_T22B2.4 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | sup-12 | ||||||||
| DB_info | Database | AceView | gene | XE525 | |||||
| WormQTL | gene | WBGene00006321 | |||||||
| WormFlux | gene | WBGene00006321 | |||||||
| NDB | locus_tag | CELE_T22B2.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006321|UniProtKB=O45189 | |||||||
| family | PTHR11176 | ||||||||
| NCBI | gene | 180674 | |||||||
| RefSeq | protein | NM_076273.5 | |||||||
| NM_001392755.1 | |||||||||
| TREEFAM | TREEFAM_ID | TF314235 | |||||||
| TrEMBL | UniProtAcc | H2L051 | |||||||
| O45189 | |||||||||
| UniProt_GCRP | UniProtAcc | O45189 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 14 Mar 2005 15:30:47 | WBPerson2970 | Event | Acquires_merge | WBGene00020668 | ||||
| Acquires_merge | WBGene00020668 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sup | ||||||||
| Allele (80) | |||||||||
| Legacy_information | st89 : recessive suppressor of unc-60(e677) and at least two other unc-60 alleles (e723 e890); abnormal gonad and minor changes in body wall muscle ultrastructure alone; ES3 in presence of e677. NA > 10. | ||||||||
| [C.elegansII] st89 : recessive suppressor of unc-60(e677) and other unc-60 alleles; (e723, e890);alone, abnormal gonad and minor changes in body wall muscle ultrastructure ES3 in presence of e677. OA>10: st86 (suppresses lethal allele unc-60(s1586) to viable ts sterile phenotype), etc. [Francis and Waterston 1985; BC] | |||||||||
| Strain | WBStrain00001641 | ||||||||
| WBStrain00001906 | |||||||||
| WBStrain00033510 | |||||||||
| WBStrain00036719 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Ortholog (39) | |||||||||
| Paralog (15) | |||||||||
| Structured_description | Concise_description | sup-12 encodes an RNA-binding protein that contains a conserved RNA recognition motif (RRM); during development, SUP-12 functions as a muscle-specific splicing factor to regulate alternative pre-mRNA processing of unc-60 and egl-15 transcripts; in vitro, SUP-12 can bind intronic regions of the unc-60 and egl-15 pre-mRNAs; specifically, SUP-12 binds the unc-60 intron 1A cooperatively with ASD-2, with which it physically interacts, to regulate alternative unc-60 pre-mRNA processing; a sup-12::gfp promoter fusion is expressed in body wall muscle and the pharynx; in body wall muscle, SUP-12::GFP localizes to nuclei in a speckled pattern. | Paper_evidence | WBPaper00024604 | |||||
| WBPaper00031074 | |||||||||
| WBPaper00041641 | |||||||||
| WBPaper00041980 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 12 Mar 2013 00:00:00 | ||||||||
| Automated_description | Enables pre-mRNA intronic binding activity and single-stranded RNA binding activity. Involved in several processes, including alternative mRNA splicing, via spliceosome; regulation of actin cytoskeleton organization; and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Part of ribonucleoprotein complex. Is an ortholog of human RBM24 (RNA binding motif protein 24) and RBM38 (RNA binding motif protein 38). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T22B2.4a | |||||||
| T22B2.4b | |||||||||
| Corresponding_CDS_history | T22B2.4:wp192 | ||||||||
| Corresponding_transcript | T22B2.4a.1 | ||||||||
| T22B2.4b.1 | |||||||||
| T22B2.4b.2 | |||||||||
| Other_sequence (49) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00053785 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00062574 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00035785 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062575 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram849 | ||||||||
| Expr3470 | |||||||||
| Expr6740 | |||||||||
| Expr6741 | |||||||||
| Expr1028589 | |||||||||
| Expr1032553 | |||||||||
| Expr1157336 | |||||||||
| Expr2017125 | |||||||||
| Expr2035261 | |||||||||
| Drives_construct | WBCnstr00002480 | ||||||||
| WBCnstr00004354 | |||||||||
| WBCnstr00011407 | |||||||||
| WBCnstr00034396 | |||||||||
| Construct_product | WBCnstr00011407 | ||||||||
| WBCnstr00034396 | |||||||||
| Antibody | WBAntibody00000799 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (165) | |||||||||
| Interaction (46) | |||||||||
| Map_info | Map | X | Position | -9.16547 | Error | 0.055758 | |||
| Positive | Positive_clone | T22B2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 1820 | |||||||
| Multi_point | 794 | ||||||||
| 4476 | |||||||||
| Pos_neg_data | 8505 | ||||||||
| Reference (20) | |||||||||
| Method | Gene |
