WormBase Tree Display for Gene: WBGene00005006
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| WBGene00005006 | SMap | S_parent | Sequence | D1014 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | spr-1 | Person_evidence | WBPerson220 | |||||
| Sequence_name | D1014.8 | ||||||||
| Molecular_name | D1014.8 | ||||||||
| D1014.8.1 | |||||||||
| CE27749 | |||||||||
| Other_name | slr-10 | Paper_evidence | WBPaper00028752 | ||||||
| CELE_D1014.8 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | spr-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 07 Feb 2007 09:07:45 | WBPerson2970 | Name_change | Other_name | slr-10 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | spr | ||||||||
| Allele (35) | |||||||||
| Legacy_information | [Iva Greenwald] suppressor of sel-12 presenilin Egl phenotype | ||||||||
| Strain | WBStrain00036731 | ||||||||
| WBStrain00036898 | |||||||||
| WBStrain00008051 | |||||||||
| WBStrain00008052 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00062828 | ||||||||
| 00062829 | |||||||||
| 00062830 | |||||||||
| 00062831 | |||||||||
| 00062832 | |||||||||
| 00062833 | |||||||||
| 00062834 | |||||||||
| 00062835 | |||||||||
| 00062836 | |||||||||
| Ortholog (32) | |||||||||
| Paralog | WBGene00010012 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00022278 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00009224 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00022215 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00013632 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | spr-1 encodes the C. elegans ortholog of the human corepressor CoREST that functions in HDAC-containing complexes to mediate transcriptional repression; in C. elegans, spr-1 was first identified in screens for genetic suppressors of the egg-laying defective phenotype of sel-12/presenilin mutants; subsequent genetic analyses showed that spr-1 likely functions as a negative regulator of LIN-12/Notch signaling in multiple cells, including those of the somatic gonad, vulva, and early embryo; spr-1 also interacts genetically with sem-5 to regulate postembryonic growth rates and lin-35Rb to regulate vulval morphogenesis and germline proliferation; in binding assays and yeast two-hybrid experiments, SPR-1 interacts with SPR-5, the C. elegans ortholog of the LSD1 histone demethylase; an SPR-1::MYC fusion protein expressed under the control of the cog-2 promoter localizes to the nucleus and shows increased staining in nuclear speckles and what appears to be the nucleolus. | Paper_evidence | WBPaper00004474 | |||||
| WBPaper00005525 | |||||||||
| WBPaper00005564 | |||||||||
| WBPaper00028752 | |||||||||
| WBPaper00031036 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 05 Mar 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex and transcription regulator complex. Used to study Alzheimer's disease. Is an ortholog of human RCOR1 (REST corepressor 1); RCOR2 (REST corepressor 2); and RCOR3 (REST corepressor 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:10652 | Homo sapiens | Paper_evidence | WBPaper00045043 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 21 Oct 2014 00:00:00 | ||||||||
| Disease_relevance | Human RE1-silencing transcription factor (REST), also known as Neuron-restrictive silencer factor (NRSF) is a transcriptional repressor, also involved in repression of neuronal genes during embryonic development that is down-regulated after terminal neuronal differentiation; recent transcriptional profiling data indicate that REST is induced in the aging brain and declines in Alzhemier''s disease (AD); REST is neuroprotective, repressing genes involved in cell death and strongly inhibiting tau phosphorylation, associated with AD; REST-deficient mice showed a progressive age-related neurodegenerative phenotype; in C. elegans, mutations in the multi-zinc finger transcripton factors, spr-3 and spr-4, structurally resembling mammalian REST, and a mutation in spr-1, orthologous to CoREST, showed significantly reduced survival relative to wild-type controls, with spr-4(by105) most affected; further, transgenic expression of human REST could functionally replace wild-type spr-4, as indicated by reducing paraquat-induced elevated ROS levels in spr-4(by105) and by repressing the presenilin gene hop-1, which is repressed by SPR-4; SPR-4 also modulated the neurotoxicity of A-beta in an C. elegans line that expresses A-beta42 in glutamatergic neurons and undergoes age-dependent neuronal loss, when this line was crossed with the spr-4(by105) mutant, the resulting line expressed A-beta42 and showed significantly accelerated neurodegeneration; thus, SPR-4 protects against both oxidative stress and A-beta toxicity, consistent with a general role in stress resistance. | Homo sapiens | Paper_evidence | WBPaper00045043 | |||||
| Accession_evidence | OMIM | 600571 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 22 Oct 2014 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000799 | ||||||||
| Molecular_info | Corresponding_CDS | D1014.8 | |||||||
| Corresponding_transcript | D1014.8.1 | ||||||||
| Other_sequence | CBC07329_1 | ||||||||
| FG647793.1 | |||||||||
| Associated_feature | WBsf652825 | ||||||||
| WBsf652826 | |||||||||
| WBsf978695 | |||||||||
| WBsf234031 | |||||||||
| WBsf234032 | |||||||||
| Transcription_factor | WBTranscriptionFactor000886 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00043347 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00008065 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066933 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00043348 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00022755 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00030322 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00012500 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00012501 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2253 | ||||||||
| Expr1026623 | |||||||||
| Expr1032490 | |||||||||
| Expr1147327 | |||||||||
| Expr2016088 | |||||||||
| Expr2034323 | |||||||||
| Drives_construct | WBCnstr00035273 | ||||||||
| Construct_product | WBCnstr00010730 | ||||||||
| WBCnstr00021756 | |||||||||
| WBCnstr00035273 | |||||||||
| Regulate_expr_cluster | WBPaper00061203:spr-1(ok2144)_downregulated | ||||||||
| WBPaper00061203:spr-1(ok2144)_upregulated | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (112) | |||||||||
| Interaction (71) | |||||||||
| Anatomy_function | WBbtf0176 | ||||||||
| Map_info | Map | V | Position | 1.01699 | Error | 0.006305 | |||
| Positive | Positive_clone | D1014 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4040 | |||||||
| 4712 | |||||||||
| 5433 | |||||||||
| Reference (22) | |||||||||
| Remark | published in Wen et al., PNAS 97: 14527-14529, 2000 | ||||||||
| Description and Allele (ar) data extracted from Wen et al. 2000 [ck1 020828] | |||||||||
| Method | Gene |
